ENSG00000169660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337014 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding protein_coding 20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 4.5061312 6.513044 7.052525 0.75746049 0.22858009 0.11463883 0.21394167 0.22486667 0.2455333 0.020666667 7.779970e-01 1.342807e-14 FALSE TRUE
ENST00000581482 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding nonsense_mediated_decay 20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 0.5323073 1.791094 0.000000 0.30784692 0.00000000 -7.49273004 0.03325833 0.06160000 0.0000000 -0.061600000 1.342807e-14 1.342807e-14 FALSE FALSE
ENST00000583978 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding retained_intron 20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 3.3994518 2.814468 3.612086 0.31131426 0.52671916 0.35884148 0.18894167 0.09683333 0.1257667 0.028933333 7.302989e-01 1.342807e-14   FALSE
ENST00000585077 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding retained_intron 20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 1.4470536 4.180556 1.852513 0.92628076 1.12411677 -1.16989134 0.07899583 0.14383333 0.0656000 -0.078233333 7.438047e-01 1.342807e-14 FALSE TRUE
ENST00000644009 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding protein_coding 20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 3.1236233 2.493365 5.840914 1.12354335 2.00461370 1.22479324 0.11083333 0.08593333 0.2037000 0.117766667 5.018812e-01 1.342807e-14 FALSE TRUE
ENST00000644886 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding retained_intron 20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 2.4051815 4.795088 3.258526 0.49088176 0.90589367 -0.55592282 0.13043750 0.16530000 0.1133667 -0.051933333 5.939637e-01 1.342807e-14 FALSE TRUE
MSTRG.15351.14 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding   20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 1.2136011 2.028067 2.128209 0.49448068 1.07979970 0.06920134 0.06177500 0.06976667 0.0734000 0.003633333 8.809326e-01 1.342807e-14 TRUE TRUE
MSTRG.15351.23 ENSG00000169660 HEK293_DMSO_6hA HEK293_OSMI2_6hA HEXD protein_coding   20.39204 29.02606 28.70815 0.2493279 0.5618042 -0.01588284 1.1881383 2.544214 1.420552 0.07865831 0.09419748 -0.83630719 0.05751250 0.08760000 0.0494000 -0.038200000 1.035429e-01 1.342807e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000169660 E001 0.000000       17 82418318 82418346 29 +      
ENSG00000169660 E002 43.133023 0.0066027321 2.578630e-02 0.261375428 17 82418347 82418660 314 + 1.701 1.576 -0.424
ENSG00000169660 E003 9.988771 0.0510393041 4.772907e-01 0.817937633 17 82418661 82418672 12 + 1.071 1.010 -0.223
ENSG00000169660 E004 11.359722 0.0382167599 9.725606e-02 0.452384683 17 82418673 82418686 14 + 1.182 0.995 -0.677
ENSG00000169660 E005 10.969929 0.0185254290 1.488419e-01 0.537633428 17 82418687 82418689 3 + 1.154 1.007 -0.531
ENSG00000169660 E006 13.235476 0.0205342435 6.851716e-01 0.909995179 17 82418690 82418696 7 + 1.171 1.145 -0.092
ENSG00000169660 E007 14.851238 0.0156625296 4.404244e-01 0.798022345 17 82418697 82418712 16 + 1.233 1.174 -0.211
ENSG00000169660 E008 15.379350 0.0119177683 4.770626e-01 0.817808813 17 82418713 82418715 3 + 1.242 1.192 -0.178
ENSG00000169660 E009 20.593955 0.0038198005 3.344455e-01 0.727923756 17 82418716 82418740 25 + 1.366 1.307 -0.205
ENSG00000169660 E010 45.709921 0.0012877942 4.302935e-02 0.323700542 17 82419749 82419799 51 + 1.715 1.624 -0.308
ENSG00000169660 E011 109.010211 0.0066316766 2.006484e-01 0.604136314 17 82419800 82419883 84 + 2.062 2.018 -0.147
ENSG00000169660 E012 51.634879 0.0270356728 4.326881e-01 0.793294253 17 82419884 82420296 413 + 1.748 1.694 -0.182
ENSG00000169660 E013 31.908149 0.0127763275 5.270732e-01 0.843464671 17 82420297 82420496 200 + 1.528 1.497 -0.108
ENSG00000169660 E014 8.089498 0.0099609603 1.450629e-01 0.532342506 17 82423310 82423599 290 + 0.848 1.033 0.692
ENSG00000169660 E015 74.630135 0.0150336440 6.382175e-01 0.891432454 17 82424394 82424418 25 + 1.878 1.869 -0.031
ENSG00000169660 E016 138.573391 0.0037467392 5.092153e-01 0.834349876 17 82424419 82424503 85 + 2.143 2.135 -0.028
ENSG00000169660 E017 3.540663 0.0136112219 2.530211e-01 0.658822288 17 82428030 82428127 98 + 0.550 0.734 0.794
ENSG00000169660 E018 164.794840 0.0001968188 4.794432e-01 0.818841013 17 82428558 82428645 88 + 2.217 2.214 -0.010
ENSG00000169660 E019 190.313673 0.0003158906 9.425872e-01 0.986566745 17 82433658 82433799 142 + 2.268 2.286 0.061
ENSG00000169660 E020 105.633624 0.0008116045 3.280658e-01 0.723080131 17 82433800 82433822 23 + 2.033 2.015 -0.062
ENSG00000169660 E021 219.117849 0.0019434973 2.109624e-01 0.615258429 17 82435689 82435872 184 + 2.349 2.329 -0.066
ENSG00000169660 E022 129.963626 0.0050495150 1.298214e-02 0.196109349 17 82436667 82436728 62 + 2.159 2.066 -0.310
ENSG00000169660 E023 81.593656 0.0046303242 6.121565e-02 0.374703923 17 82436729 82436738 10 + 1.950 1.874 -0.255
ENSG00000169660 E024 78.745781 0.0435002300 6.216144e-02 0.377406509 17 82436739 82437126 388 + 1.799 1.973 0.587
ENSG00000169660 E025 32.759578 0.0270779986 9.425671e-02 0.446679123 17 82437127 82437167 41 + 1.429 1.594 0.565
ENSG00000169660 E026 122.731102 0.0003084944 7.362890e-06 0.002472398 17 82437168 82437214 47 + 2.148 2.021 -0.424
ENSG00000169660 E027 187.518311 0.0024813253 5.903452e-03 0.136699894 17 82437215 82437363 149 + 2.311 2.236 -0.249
ENSG00000169660 E028 142.153397 0.0015851263 1.256354e-01 0.503462359 17 82439631 82439713 83 + 2.170 2.135 -0.117
ENSG00000169660 E029 86.436892 0.0969586780 1.498841e-01 0.539360294 17 82439714 82439999 286 + 1.858 2.002 0.482
ENSG00000169660 E030 63.485023 0.0994110764 1.335781e-01 0.515595565 17 82440000 82440113 114 + 1.707 1.881 0.589
ENSG00000169660 E031 52.104961 0.1305545876 2.558576e-01 0.661573948 17 82440114 82440173 60 + 1.659 1.774 0.388
ENSG00000169660 E032 50.016565 0.0693106577 9.513743e-02 0.448438527 17 82440174 82440262 89 + 1.592 1.788 0.664
ENSG00000169660 E033 44.269624 0.0466696473 6.807088e-02 0.391436343 17 82440263 82440334 72 + 1.541 1.732 0.653
ENSG00000169660 E034 53.504853 0.0354672164 4.520629e-02 0.330528085 17 82440335 82440472 138 + 1.627 1.809 0.615
ENSG00000169660 E035 67.625492 0.0203154030 1.704551e-02 0.220862355 17 82440473 82440613 141 + 1.722 1.909 0.631
ENSG00000169660 E036 176.221892 0.0006150580 6.927096e-01 0.912693439 17 82440997 82441070 74 + 2.243 2.247 0.015
ENSG00000169660 E037 105.349431 0.0004144038 2.762292e-01 0.679961728 17 82441071 82441075 5 + 1.992 2.045 0.179
ENSG00000169660 E038 91.993622 0.0033346247 6.137875e-03 0.138980156 17 82441076 82441152 77 + 1.885 2.024 0.467
ENSG00000169660 E039 61.728824 0.0116846796 8.502121e-02 0.428074253 17 82441153 82441164 12 + 1.716 1.855 0.469
ENSG00000169660 E040 203.931382 0.0002427844 2.825603e-01 0.685473604 17 82441165 82441266 102 + 2.284 2.327 0.142
ENSG00000169660 E041 25.633686 0.0067267061 3.907235e-03 0.111794347 17 82441744 82441799 56 + 1.282 1.521 0.826
ENSG00000169660 E042 118.721788 0.0003872616 8.471681e-01 0.962188762 17 82441800 82441820 21 + 2.067 2.076 0.032
ENSG00000169660 E043 180.236960 0.0003240879 5.777433e-01 0.865805142 17 82441821 82441889 69 + 2.252 2.253 0.005
ENSG00000169660 E044 300.077556 0.0055443688 8.457150e-01 0.961784575 17 82442177 82442645 469 + 2.468 2.484 0.054