ENSG00000168944

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306467 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding protein_coding 4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 0.44006351 0.19368868 0.54861076 0.09734077 0.13750738 1.4554775 0.1338083 0.138133333 0.4295333 0.29140000 0.5423708085 0.0002176434 FALSE TRUE
ENST00000306481 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding protein_coding 4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 0.61921238 0.00000000 0.26065856 0.00000000 0.26065856 4.7584021 0.1465542 0.000000000 0.1775000 0.17750000 0.7509910802 0.0002176434 FALSE TRUE
ENST00000328236 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding protein_coding 4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 0.98061909 0.00000000 0.36755264 0.00000000 0.36755264 5.2386059 0.1735000 0.000000000 0.2352333 0.23523333 0.7486840590 0.0002176434 FALSE TRUE
ENST00000675283 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding retained_intron 4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 0.08528165 0.46288620 0.03216848 0.06987073 0.03216848 -3.4872561 0.0498375 0.282533333 0.0219000 -0.26063333 0.1379478847 0.0002176434 FALSE TRUE
ENST00000675330 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding protein_coding 4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 0.21212557 0.21710983 0.00000000 0.18527721 0.00000000 -4.5053182 0.0513750 0.078900000 0.0000000 -0.07890000 0.4153899806 0.0002176434 FALSE TRUE
ENST00000675564 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding retained_intron 4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 0.15736371 0.03912325 0.00000000 0.03912325 0.00000000 -2.2964060 0.1016333 0.029433333 0.0000000 -0.02943333 0.7957398658 0.0002176434 FALSE TRUE
ENST00000676068 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding retained_intron 4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 0.09998271 0.60276513 0.00000000 0.20879391 0.00000000 -5.9372623 0.0510500 0.301333333 0.0000000 -0.30133333 0.0002176434 0.0002176434 FALSE TRUE
MSTRG.26823.1 ENSG00000168944 HEK293_DMSO_6hA HEK293_OSMI2_6hA CEP120 protein_coding   4.22062 1.977125 1.378797 0.5768954 0.1393462 -0.5168466 1.09383381 0.01455196 0.03494615 0.01455196 0.03494615 0.8723595 0.1635333 0.009866667 0.0238000 0.01393333 0.8953936147 0.0002176434 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000168944 E001 1.2117582 0.229512121 0.5123445928   5 123344146 123344258 113 - 0.241 0.380 0.913
ENSG00000168944 E002 0.0000000       5 123344890 123344891 2 -      
ENSG00000168944 E003 0.4481873 0.021768165 0.4094776897   5 123344892 123344894 3 - 0.236 0.107 -1.370
ENSG00000168944 E004 0.6026480 0.020941271 0.7618572478   5 123344895 123344907 13 - 0.236 0.192 -0.371
ENSG00000168944 E005 5.4643469 0.007292433 0.0595773558 0.37053386 5 123344908 123345002 95 - 0.628 0.901 1.102
ENSG00000168944 E006 72.8307693 0.006776258 0.1412136668 0.52695241 5 123345003 123346399 1397 - 1.808 1.895 0.291
ENSG00000168944 E007 17.3814181 0.006514641 0.3017846618 0.70134122 5 123346400 123346604 205 - 1.197 1.300 0.362
ENSG00000168944 E008 21.1260314 0.001581727 0.3344026344 0.72787108 5 123346605 123346753 149 - 1.295 1.382 0.305
ENSG00000168944 E009 0.1125166 0.032780591 0.3746550947   5 123346754 123346809 56 - 0.133 0.000 -12.680
ENSG00000168944 E010 17.3920456 0.048710464 0.3838240010 0.76282822 5 123349944 123350089 146 - 1.190 1.317 0.447
ENSG00000168944 E011 6.2079470 0.176543345 0.4420109774 0.79878061 5 123350090 123352576 2487 - 0.744 0.908 0.641
ENSG00000168944 E012 0.4884942 0.021768165 0.1435256393   5 123358244 123358251 8 - 0.000 0.264 12.871
ENSG00000168944 E013 0.6429549 0.021321421 0.0739542916   5 123358252 123358445 194 - 0.000 0.325 13.235
ENSG00000168944 E014 1.2243314 0.013803744 0.7725363176   5 123358446 123358806 361 - 0.318 0.379 0.369
ENSG00000168944 E015 14.8230879 0.054236830 0.6012140377 0.87598810 5 123364496 123364594 99 - 1.132 1.247 0.407
ENSG00000168944 E016 0.4638576 0.024954482 0.7469331758   5 123364595 123364795 201 - 0.133 0.193 0.635
ENSG00000168944 E017 14.1525603 0.008794020 0.5500156296 0.85398628 5 123372650 123372751 102 - 1.133 1.211 0.278
ENSG00000168944 E018 6.7577228 0.044400574 0.6284123868 0.88723155 5 123372752 123372772 21 - 0.830 0.927 0.371
ENSG00000168944 E019 16.4276973 0.018234964 0.9980713193 0.99946681 5 123377374 123377535 162 - 1.239 1.247 0.028
ENSG00000168944 E020 10.7963773 0.041353381 0.9659329744 0.99217974 5 123378336 123378428 93 - 1.069 1.065 -0.012
ENSG00000168944 E021 0.1544607 0.032649190 0.6322387786   5 123381756 123382110 355 - 0.000 0.107 11.385
ENSG00000168944 E022 10.4928810 0.002434975 0.5539420086 0.85547363 5 123382111 123382200 90 - 1.085 1.043 -0.154
ENSG00000168944 E023 18.5346081 0.020177937 0.2199627487 0.62449264 5 123382737 123382889 153 - 1.340 1.227 -0.397
ENSG00000168944 E024 16.2350153 0.047095296 0.3302332339 0.72480696 5 123382986 123383082 97 - 1.288 1.171 -0.411
ENSG00000168944 E025 0.8571427 0.021581449 0.0370658527   5 123383083 123383399 317 - 0.000 0.379 13.512
ENSG00000168944 E026 14.8869916 0.002252825 0.4183359460 0.78535537 5 123384951 123385133 183 - 1.227 1.174 -0.187
ENSG00000168944 E027 0.0000000       5 123385802 123386517 716 -      
ENSG00000168944 E028 10.3034153 0.002827276 0.0726075590 0.40145455 5 123386518 123386667 150 - 1.145 0.984 -0.585
ENSG00000168944 E029 0.3089214 0.052892132 0.3098097530   5 123388304 123388431 128 - 0.000 0.192 12.257
ENSG00000168944 E030 13.6140093 0.002719457 0.0493857118 0.34266297 5 123388432 123388606 175 - 1.253 1.094 -0.565
ENSG00000168944 E031 11.2161695 0.002647347 0.0315138843 0.28538458 5 123389924 123390005 82 - 1.188 0.996 -0.691
ENSG00000168944 E032 10.0478152 0.016732159 0.1695538102 0.56657816 5 123390006 123390140 135 - 1.121 0.971 -0.547
ENSG00000168944 E033 0.4214379 0.029855246 0.7636619592   5 123390141 123390365 225 - 0.133 0.192 0.632
ENSG00000168944 E034 0.9517497 0.193061192 0.2947788107   5 123390366 123391109 744 - 0.392 0.191 -1.409
ENSG00000168944 E035 11.7762860 0.002273952 0.4912346915 0.82514765 5 123391110 123391337 228 - 1.134 1.085 -0.177
ENSG00000168944 E036 11.1290215 0.020465151 0.6721648740 0.90492639 5 123393300 123393497 198 - 1.054 1.104 0.181
ENSG00000168944 E037 9.2977726 0.014873754 0.3883322338 0.76600884 5 123399136 123399284 149 - 0.934 1.043 0.405
ENSG00000168944 E038 13.0517763 0.077306256 0.0004638809 0.03453245 5 123399285 123400649 1365 - 0.709 1.292 2.176
ENSG00000168944 E039 0.8119208 0.019276117 0.2993489331   5 123403217 123403255 39 - 0.134 0.325 1.626
ENSG00000168944 E040 0.9535135 0.487371718 0.5719165092   5 123403256 123403344 89 - 0.137 0.370 1.853
ENSG00000168944 E041 1.1436276 0.016090562 0.9960904547   5 123403694 123403740 47 - 0.318 0.325 0.044
ENSG00000168944 E042 0.0000000       5 123409832 123409948 117 -      
ENSG00000168944 E043 7.6586733 0.030053630 0.0342834508 0.29490637 5 123412399 123412540 142 - 1.061 0.815 -0.928
ENSG00000168944 E044 7.3675071 0.082218840 0.1521371982 0.54221272 5 123416010 123416124 115 - 1.013 0.829 -0.694
ENSG00000168944 E045 6.1298600 0.037878203 0.0077749597 0.15459333 5 123418359 123418515 157 - 1.020 0.662 -1.398
ENSG00000168944 E046 0.0000000       5 123422467 123422575 109 -      
ENSG00000168944 E047 0.0000000       5 123422576 123422949 374 -      
ENSG00000168944 E048 3.5529314 0.006007761 0.0330284463 0.29077046 5 123422950 123423030 81 - 0.806 0.509 -1.276
ENSG00000168944 E049 4.9038919 0.010532120 0.2514877634 0.65743967 5 123423031 123423421 391 - 0.832 0.690 -0.571
ENSG00000168944 E050 0.1125166 0.032780591 0.3746550947   5 123423509 123423592 84 - 0.133 0.000 -12.680