ENSG00000168488

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340394 ENSG00000168488 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATXN2L protein_coding protein_coding 79.36699 78.75609 104.5399 0.6861785 10.73496 0.4085453 12.344408 8.2895756 19.165900 0.8687328 1.8505595 1.2081848 0.15791667 0.105100000 0.18366667 0.07856667 0.000528827 0.000528827 FALSE TRUE
ENST00000567024 ENSG00000168488 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATXN2L protein_coding protein_coding 79.36699 78.75609 104.5399 0.6861785 10.73496 0.4085453 5.064155 6.1482697 4.850933 2.1734543 1.5641429 -0.3412919 0.05697917 0.078200000 0.04473333 -0.03346667 0.741099240 0.000528827   FALSE
MSTRG.12366.10 ENSG00000168488 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATXN2L protein_coding   79.36699 78.75609 104.5399 0.6861785 10.73496 0.4085453 4.246826 0.7894001 3.070346 0.7894001 1.5525062 1.9461028 0.05565000 0.009933333 0.02676667 0.01683333 0.720592001 0.000528827 FALSE TRUE
MSTRG.12366.27 ENSG00000168488 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATXN2L protein_coding   79.36699 78.75609 104.5399 0.6861785 10.73496 0.4085453 4.955364 4.0802365 6.586319 0.1781764 0.5776792 0.6894770 0.06292917 0.051766667 0.06370000 0.01193333 0.634917932 0.000528827 TRUE TRUE
MSTRG.12366.28 ENSG00000168488 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATXN2L protein_coding   79.36699 78.75609 104.5399 0.6861785 10.73496 0.4085453 20.356624 26.3476427 30.270516 0.3033443 0.8106801 0.2001684 0.25639167 0.334633333 0.29540000 -0.03923333 0.699153252 0.000528827 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000168488 E001 15.285828 5.183703e-03 2.584647e-01 0.66410942 16 28822999 28823034 36 + 1.247 1.154 -0.332
ENSG00000168488 E002 13.750139 1.960911e-03 5.865943e-01 0.86982363 16 28823035 28823047 13 + 1.182 1.142 -0.142
ENSG00000168488 E003 28.804300 9.138093e-04 6.168586e-01 0.88280009 16 28823048 28823092 45 + 1.452 1.494 0.143
ENSG00000168488 E004 21.687175 1.283968e-03 6.798887e-01 0.90814373 16 28823093 28823094 2 + 1.337 1.377 0.136
ENSG00000168488 E005 92.728449 1.002852e-03 1.325671e-01 0.51410699 16 28823095 28823251 157 + 1.993 1.944 -0.165
ENSG00000168488 E006 145.406582 1.740524e-03 1.203532e-02 0.18961409 16 28823252 28823481 230 + 2.197 2.120 -0.259
ENSG00000168488 E007 121.936483 4.057311e-03 1.347068e-01 0.51733874 16 28823482 28823558 77 + 2.113 2.059 -0.181
ENSG00000168488 E008 30.609501 9.352813e-03 4.501803e-01 0.80365736 16 28824138 28824271 134 + 1.510 1.468 -0.145
ENSG00000168488 E009 22.492284 1.060009e-02 4.175194e-01 0.78495382 16 28824272 28824311 40 + 1.389 1.336 -0.186
ENSG00000168488 E010 42.585129 6.447501e-04 1.422666e-01 0.52854851 16 28824312 28824450 139 + 1.663 1.594 -0.236
ENSG00000168488 E011 57.341498 6.169824e-04 5.850507e-02 0.36773827 16 28824451 28824542 92 + 1.794 1.714 -0.270
ENSG00000168488 E012 13.429588 4.390710e-02 7.567347e-01 0.93475079 16 28824543 28824661 119 + 1.123 1.178 0.195
ENSG00000168488 E013 140.094446 2.390291e-04 9.580469e-02 0.44972381 16 28825366 28825370 5 + 2.166 2.125 -0.136
ENSG00000168488 E014 210.093338 1.857967e-04 2.319898e-03 0.08592491 16 28825371 28825402 32 + 2.351 2.285 -0.221
ENSG00000168488 E015 294.731868 1.320875e-04 4.185986e-03 0.11599590 16 28825624 28825680 57 + 2.490 2.439 -0.167
ENSG00000168488 E016 5.369816 4.513927e-03 7.302015e-02 0.40221723 16 28825681 28825769 89 + 0.683 0.922 0.945
ENSG00000168488 E017 432.561716 8.181562e-04 7.809256e-01 0.94249354 16 28825770 28825841 72 + 2.630 2.636 0.020
ENSG00000168488 E018 7.242428 3.005473e-01 1.368861e-01 0.52073592 16 28825842 28826184 343 + 0.675 1.089 1.594
ENSG00000168488 E019 753.971431 2.060066e-04 6.247478e-01 0.88591335 16 28826240 28826390 151 + 2.865 2.883 0.059
ENSG00000168488 E020 5.882769 4.056563e-03 1.503791e-04 0.01723073 16 28826391 28826605 215 + 0.539 1.039 2.015
ENSG00000168488 E021 637.652035 7.928618e-05 3.762788e-01 0.75750864 16 28826862 28826923 62 + 2.791 2.813 0.076
ENSG00000168488 E022 589.363862 8.249435e-05 6.330870e-01 0.88923357 16 28826924 28826986 63 + 2.767 2.770 0.010
ENSG00000168488 E023 596.922714 8.093081e-05 2.534538e-01 0.65925848 16 28829401 28829492 92 + 2.776 2.769 -0.022
ENSG00000168488 E024 6.895693 3.651686e-01 1.219631e-01 0.49713137 16 28829778 28829857 80 + 0.737 1.024 1.104
ENSG00000168488 E025 302.647469 1.796099e-04 1.564269e-01 0.54866959 16 28829858 28829868 11 + 2.486 2.467 -0.065
ENSG00000168488 E026 713.510055 1.110352e-03 3.031459e-02 0.28077782 16 28829869 28830058 190 + 2.864 2.833 -0.100
ENSG00000168488 E027 672.640391 7.834910e-04 9.707704e-02 0.45199536 16 28830615 28830790 176 + 2.835 2.815 -0.069
ENSG00000168488 E028 7.561574 5.242671e-02 2.633826e-03 0.09206834 16 28830791 28830802 12 + 0.657 1.129 1.814
ENSG00000168488 E029 6.664663 1.678059e-01 9.799695e-03 0.17207774 16 28830803 28830936 134 + 0.543 1.101 2.219
ENSG00000168488 E030 376.185464 5.278922e-04 3.030268e-02 0.28077782 16 28830962 28830984 23 + 2.592 2.555 -0.122
ENSG00000168488 E031 567.152658 3.491906e-04 1.071317e-02 0.17909344 16 28830985 28831072 88 + 2.767 2.733 -0.113
ENSG00000168488 E032 30.828953 2.146630e-02 1.696366e-01 0.56658934 16 28832187 28832204 18 + 1.427 1.569 0.486
ENSG00000168488 E033 999.677550 2.889462e-04 4.168488e-02 0.31953594 16 28832205 28832399 195 + 3.004 2.987 -0.057
ENSG00000168488 E034 620.656726 4.919756e-04 5.722227e-01 0.86314890 16 28832496 28832567 72 + 2.789 2.790 0.002
ENSG00000168488 E035 686.133005 8.948969e-05 7.218259e-01 0.92272722 16 28832817 28832887 71 + 2.826 2.841 0.050
ENSG00000168488 E036 929.227869 2.048980e-03 3.087549e-01 0.70708211 16 28833059 28833195 137 + 2.970 2.960 -0.034
ENSG00000168488 E037 876.330688 8.818779e-04 3.235014e-01 0.71958723 16 28833196 28833354 159 + 2.943 2.937 -0.022
ENSG00000168488 E038 582.278698 5.310353e-04 5.098322e-01 0.83466337 16 28833439 28833508 70 + 2.765 2.763 -0.007
ENSG00000168488 E039 33.760311 1.768078e-01 1.172328e-02 0.18723269 16 28833856 28834064 209 + 1.277 1.725 1.539
ENSG00000168488 E040 828.407196 1.774214e-04 5.239847e-01 0.84216423 16 28834065 28834211 147 + 2.916 2.918 0.006
ENSG00000168488 E041 6.521331 2.634369e-02 2.515623e-02 0.25924905 16 28834329 28834342 14 + 0.687 1.009 1.251
ENSG00000168488 E042 564.963117 1.463040e-03 8.783766e-02 0.43395558 16 28834343 28834415 73 + 2.763 2.735 -0.094
ENSG00000168488 E043 325.448035 2.663428e-04 6.006844e-04 0.04049586 16 28834506 28834522 17 + 2.539 2.477 -0.205
ENSG00000168488 E044 750.183257 8.231240e-04 1.767382e-03 0.07469005 16 28834523 28834693 171 + 2.895 2.848 -0.155
ENSG00000168488 E045 11.755931 3.045952e-02 6.503555e-02 0.38439431 16 28834852 28835057 206 + 0.978 1.216 0.858
ENSG00000168488 E046 421.417579 1.505802e-04 9.957402e-03 0.17307195 16 28835058 28835098 41 + 2.640 2.604 -0.120
ENSG00000168488 E047 588.341102 5.893889e-04 3.497041e-02 0.29739943 16 28835099 28835187 89 + 2.782 2.753 -0.095
ENSG00000168488 E048 12.537633 2.005781e-01 7.038383e-02 0.39649287 16 28835188 28835277 90 + 0.950 1.271 1.161
ENSG00000168488 E049 725.431926 1.894460e-04 6.257280e-02 0.37858739 16 28835278 28835399 122 + 2.866 2.850 -0.054
ENSG00000168488 E050 34.311370 1.413459e-01 5.447585e-03 0.13186332 16 28835400 28835545 146 + 1.265 1.740 1.632
ENSG00000168488 E051 81.272788 3.757329e-04 5.966870e-01 0.87433162 16 28835546 28835548 3 + 1.898 1.929 0.103
ENSG00000168488 E052 327.549924 1.079953e-03 4.151883e-01 0.78363091 16 28835549 28835554 6 + 2.518 2.510 -0.026
ENSG00000168488 E053 475.582216 1.031331e-03 5.541509e-01 0.85552516 16 28835555 28835594 40 + 2.677 2.676 -0.002
ENSG00000168488 E054 515.823251 1.744947e-03 3.383435e-01 0.73078526 16 28835595 28835668 74 + 2.718 2.706 -0.041
ENSG00000168488 E055 417.278125 4.105354e-03 5.079575e-01 0.83383722 16 28835669 28835758 90 + 2.626 2.614 -0.041
ENSG00000168488 E056 562.241805 2.133969e-03 9.885780e-01 0.99720146 16 28835933 28836122 190 + 2.745 2.755 0.033
ENSG00000168488 E057 212.895096 2.561030e-04 2.159574e-05 0.00514168 16 28836123 28836176 54 + 2.272 2.387 0.385
ENSG00000168488 E058 307.966063 1.340015e-02 7.703995e-02 0.41146820 16 28836177 28836325 149 + 2.433 2.545 0.371
ENSG00000168488 E059 345.749631 1.218628e-02 3.919811e-02 0.31151888 16 28836326 28836445 120 + 2.476 2.601 0.418
ENSG00000168488 E060 184.060403 2.083453e-02 3.226253e-02 0.28834935 16 28836446 28836448 3 + 2.180 2.348 0.561
ENSG00000168488 E061 285.509311 1.246685e-02 3.731120e-02 0.30493439 16 28836449 28836485 37 + 2.389 2.522 0.443
ENSG00000168488 E062 155.509895 8.290983e-03 1.830840e-03 0.07617040 16 28836486 28836490 5 + 2.101 2.279 0.594
ENSG00000168488 E063 312.793423 1.084857e-02 3.373891e-03 0.10465186 16 28836491 28836597 107 + 2.409 2.578 0.564
ENSG00000168488 E064 413.863383 1.078106e-02 6.536914e-03 0.14245493 16 28836598 28836727 130 + 2.540 2.692 0.508
ENSG00000168488 E065 386.257883 2.385041e-03 1.413044e-01 0.52709199 16 28836728 28836747 20 + 2.560 2.614 0.182
ENSG00000168488 E066 355.052574 2.090864e-03 6.693492e-02 0.38888291 16 28836748 28836750 3 + 2.519 2.583 0.212
ENSG00000168488 E067 738.661128 8.542044e-04 9.496405e-03 0.16929959 16 28836751 28836849 99 + 2.839 2.899 0.201
ENSG00000168488 E068 1032.827762 1.283253e-03 9.132311e-02 0.44076768 16 28836850 28837237 388 + 2.991 3.037 0.154