ENSG00000168300

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000519554 ENSG00000168300 HEK293_DMSO_6hA HEK293_OSMI2_6hA PCMTD1 protein_coding protein_coding 3.944326 2.080572 1.297291 0.9687965 0.1349671 -0.6773171 0.3775608 0.1045099 0.15132848 0.05467118 0.08327826 0.4945294 0.08473333 0.04840000 0.10720000 0.05880000 7.276490e-01 3.199474e-07 FALSE FALSE
ENST00000519559 ENSG00000168300 HEK293_DMSO_6hA HEK293_OSMI2_6hA PCMTD1 protein_coding processed_transcript 3.944326 2.080572 1.297291 0.9687965 0.1349671 -0.6773171 0.6146694 0.0000000 0.08264823 0.00000000 0.04482637 3.2117634 0.10813750 0.00000000 0.06216667 0.06216667 2.290567e-01 3.199474e-07 FALSE TRUE
ENST00000519975 ENSG00000168300 HEK293_DMSO_6hA HEK293_OSMI2_6hA PCMTD1 protein_coding retained_intron 3.944326 2.080572 1.297291 0.9687965 0.1349671 -0.6773171 0.3862736 0.1468793 0.00000000 0.05461150 0.00000000 -3.9715836 0.07023750 0.07616667 0.00000000 -0.07616667 1.185938e-01 3.199474e-07 FALSE TRUE
ENST00000522514 ENSG00000168300 HEK293_DMSO_6hA HEK293_OSMI2_6hA PCMTD1 protein_coding protein_coding 3.944326 2.080572 1.297291 0.9687965 0.1349671 -0.6773171 1.9249141 0.6194670 0.82517155 0.12321193 0.03168512 0.4079418 0.52267500 0.37190000 0.64473333 0.27283333 2.817304e-01 3.199474e-07 FALSE TRUE
ENST00000544451 ENSG00000168300 HEK293_DMSO_6hA HEK293_OSMI2_6hA PCMTD1 protein_coding protein_coding 3.944326 2.080572 1.297291 0.9687965 0.1349671 -0.6773171 0.2370620 0.8453420 0.00000000 0.45190511 0.00000000 -6.4184295 0.10135417 0.38473333 0.00000000 -0.38473333 3.199474e-07 3.199474e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000168300 E001 0.0000000       8 51817575 51817579 5 -      
ENSG00000168300 E002 0.0000000       8 51817580 51817582 3 -      
ENSG00000168300 E003 94.1047817 0.0005811971 0.0038507119 0.11103143 8 51817583 51820146 2564 - 1.911 1.997 0.288
ENSG00000168300 E004 11.0366417 0.0024679833 0.0408057612 0.31680481 8 51820147 51820360 214 - 0.922 1.137 0.790
ENSG00000168300 E005 13.6729954 0.0028198282 0.3235421998 0.71960489 8 51820361 51820494 134 - 1.088 1.184 0.344
ENSG00000168300 E006 18.2195378 0.0015253220 0.9862297747 0.99666326 8 51820495 51820718 224 - 1.265 1.271 0.019
ENSG00000168300 E007 2.7869159 0.0122071682 0.5427064184 0.85118725 8 51826929 51827361 433 - 0.614 0.523 -0.413
ENSG00000168300 E008 9.8425327 0.0029839138 0.0118407334 0.18803557 8 51831444 51831567 124 - 1.162 0.917 -0.897
ENSG00000168300 E009 10.6317753 0.0024483937 0.0049194392 0.12586002 8 51833518 51833689 172 - 1.196 0.931 -0.967
ENSG00000168300 E010 2.2632438 0.2061451669 0.3656848484 0.75066007 8 51839447 51839638 192 - 0.584 0.443 -0.678
ENSG00000168300 E011 2.3070160 0.0090276718 0.0003408417 0.02859774 8 51844809 51845660 852 - 0.000 0.666 12.466
ENSG00000168300 E012 7.4967934 0.0031925867 0.0329736968 0.29070488 8 51845661 51845763 103 - 1.044 0.810 -0.884
ENSG00000168300 E013 4.6129179 0.0095908939 0.6043238211 0.87739097 8 51848945 51850086 1142 - 0.688 0.772 0.345
ENSG00000168300 E014 1.1229550 0.0145448699 0.8694396663   8 51860486 51860844 359 - 0.335 0.309 -0.160
ENSG00000168300 E015 4.1211081 0.0061717149 0.2307957168 0.63577304 8 51860845 51860860 16 - 0.781 0.615 -0.693
ENSG00000168300 E016 11.5454939 0.0023472057 0.1956374332 0.59855728 8 51860861 51861246 386 - 1.151 1.036 -0.417
ENSG00000168300 E017 0.1125166 0.0360107893 0.3444525006   8 51870248 51870390 143 - 0.142 0.000 -10.509
ENSG00000168300 E018 4.1796531 0.0064191811 0.1026682887 0.46218755 8 51898930 51899186 257 - 0.832 0.614 -0.896