ENSG00000166971

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300245 ENSG00000166971 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKTIP protein_coding protein_coding 9.401876 7.121954 6.447169 1.670321 0.8110604 -0.1433956 0.5482574 0.3543393 0.3499001 0.35433934 0.29529804 -0.01768615 0.06170833 0.03386667 0.05236667 0.01850000 0.7573791462 0.0001196455 FALSE  
ENST00000394657 ENSG00000166971 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKTIP protein_coding protein_coding 9.401876 7.121954 6.447169 1.670321 0.8110604 -0.1433956 0.8477685 0.5247093 0.8248007 0.20059596 0.41443273 0.64267710 0.09558750 0.08570000 0.11376667 0.02806667 0.9944500893 0.0001196455 FALSE  
ENST00000563108 ENSG00000166971 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKTIP protein_coding retained_intron 9.401876 7.121954 6.447169 1.670321 0.8110604 -0.1433956 0.3543176 0.5251844 0.1340749 0.13291599 0.07487085 -1.89321672 0.03635000 0.07576667 0.02416667 -0.05160000 0.4257795655 0.0001196455 FALSE  
ENST00000570004 ENSG00000166971 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKTIP protein_coding protein_coding 9.401876 7.121954 6.447169 1.670321 0.8110604 -0.1433956 0.4079444 0.5068040 0.0000000 0.09294093 0.00000000 -5.69154541 0.03892917 0.07763333 0.00000000 -0.07763333 0.0001196455 0.0001196455 FALSE  
MSTRG.12661.4 ENSG00000166971 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKTIP protein_coding   9.401876 7.121954 6.447169 1.670321 0.8110604 -0.1433956 1.1774146 0.9317482 0.8707429 0.48425699 0.09361053 -0.09662054 0.12655833 0.11630000 0.14433333 0.02803333 0.8378466116 0.0001196455 FALSE  
MSTRG.12661.5 ENSG00000166971 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKTIP protein_coding   9.401876 7.121954 6.447169 1.670321 0.8110604 -0.1433956 5.0937501 3.2526043 3.7137543 0.84491032 0.61423345 0.19073386 0.53591250 0.45330000 0.57403333 0.12073333 0.3928430249 0.0001196455 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000166971 E001 2.227059 0.1372725966 0.7393046300 0.9289251 16 53491040 53491378 339 - 0.504 0.539 0.167
ENSG00000166971 E002 4.914862 0.1185258761 0.9819190752 0.9956172 16 53491379 53491647 269 - 0.781 0.749 -0.128
ENSG00000166971 E003 3.000483 0.0183981491 0.2119456178 0.6165092 16 53491648 53491653 6 - 0.694 0.497 -0.881
ENSG00000166971 E004 30.374060 0.0106850534 0.5991416285 0.8752512 16 53491654 53491838 185 - 1.514 1.480 -0.114
ENSG00000166971 E005 84.407290 0.0003649216 0.8096536762 0.9514067 16 53491839 53492198 360 - 1.928 1.941 0.043
ENSG00000166971 E006 50.790478 0.0007590444 0.6644084387 0.9020471 16 53492199 53492304 106 - 1.726 1.709 -0.058
ENSG00000166971 E007 26.251482 0.0081474338 0.2585265541 0.6641626 16 53492305 53492306 2 - 1.484 1.395 -0.305
ENSG00000166971 E008 75.974500 0.0004997596 0.7729823535 0.9402893 16 53492307 53492519 213 - 1.896 1.889 -0.024
ENSG00000166971 E009 14.279675 0.0052331748 0.9293185291 0.9831585 16 53492520 53492522 3 - 1.197 1.195 -0.007
ENSG00000166971 E010 2.453485 0.0094732706 0.2682376622 0.6727563 16 53492523 53492692 170 - 0.422 0.608 0.894
ENSG00000166971 E011 41.691831 0.0006617436 0.5217468633 0.8409439 16 53492693 53492753 61 - 1.613 1.651 0.127
ENSG00000166971 E012 10.856812 0.2862490330 0.1159776033 0.4862128 16 53492754 53493968 1215 - 0.879 1.178 1.099
ENSG00000166971 E013 44.602394 0.0006262288 0.2517198036 0.6576408 16 53494138 53494215 78 - 1.690 1.636 -0.183
ENSG00000166971 E014 30.412090 0.0009163968 0.1056865276 0.4678246 16 53494216 53494245 30 - 1.546 1.451 -0.327
ENSG00000166971 E015 50.346195 0.0005754322 0.5063894328 0.8329441 16 53494339 53494437 99 - 1.728 1.701 -0.093
ENSG00000166971 E016 39.287970 0.0015742492 0.7698906543 0.9394114 16 53494517 53494570 54 - 1.616 1.604 -0.043
ENSG00000166971 E017 35.081948 0.0036620211 0.9980590042 0.9994643 16 53494571 53494605 35 - 1.557 1.558 0.004
ENSG00000166971 E018 3.847077 0.1249213710 0.3841425473 0.7630220 16 53494779 53494838 60 - 0.571 0.746 0.745
ENSG00000166971 E019 3.428207 0.0438427445 0.1093232447 0.4745133 16 53494839 53494955 117 - 0.474 0.747 1.213
ENSG00000166971 E020 2.977759 0.0074815550 0.0060850535 0.1384432 16 53494956 53495072 117 - 0.298 0.747 2.220
ENSG00000166971 E021 25.120516 0.0011508558 0.9226447767 0.9815232 16 53495073 53495077 5 - 1.420 1.416 -0.011
ENSG00000166971 E022 28.192629 0.0011827171 0.7190173772 0.9218335 16 53495078 53495104 27 - 1.484 1.464 -0.068
ENSG00000166971 E023 32.320438 0.0101752535 0.5889942025 0.8709190 16 53495105 53495150 46 - 1.510 1.546 0.122
ENSG00000166971 E024 25.222094 0.0012783603 0.3615004372 0.7478493 16 53495151 53495173 23 - 1.391 1.455 0.222
ENSG00000166971 E025 3.164573 0.0088626743 0.0005563324 0.0384924 16 53495174 53495261 88 - 0.219 0.793 2.985
ENSG00000166971 E026 24.094689 0.0010879066 0.1495509406 0.5388350 16 53495262 53495326 65 - 1.343 1.446 0.357
ENSG00000166971 E027 28.493519 0.0012770467 0.8602487120 0.9657466 16 53498391 53498517 127 - 1.461 1.478 0.057
ENSG00000166971 E028 24.150183 0.0137573414 0.5965419329 0.8742530 16 53498518 53498596 79 - 1.414 1.378 -0.127
ENSG00000166971 E029 30.121009 0.0016654501 0.4324092132 0.7931873 16 53500218 53500323 106 - 1.513 1.469 -0.151
ENSG00000166971 E030 12.860834 0.0025807913 0.1525962150 0.5428282 16 53500324 53500329 6 - 1.207 1.079 -0.456
ENSG00000166971 E031 4.777901 0.0051359016 0.0060834732 0.1384399 16 53501106 53501520 415 - 0.518 0.905 1.617
ENSG00000166971 E032 1.839847 0.0099854489 0.6662777488 0.9027965 16 53501521 53501570 50 - 0.421 0.497 0.385
ENSG00000166971 E033 2.093177 0.0114941083 0.4969017932 0.8277418 16 53501727 53501769 43 - 0.422 0.537 0.576
ENSG00000166971 E034 4.205837 0.0065144585 0.5860476368 0.8695292 16 53502700 53503044 345 - 0.664 0.747 0.342
ENSG00000166971 E035 1.508998 0.5069844550 0.5459146448   16 53503045 53503117 73 - 0.313 0.449 0.779
ENSG00000166971 E036 1.511801 0.0336396416 0.1294345945   16 53503118 53503146 29 - 0.220 0.497 1.696
ENSG00000166971 E037 11.456007 0.0022163504 0.2580942670 0.6638192 16 53503147 53503244 98 - 1.150 1.045 -0.379
ENSG00000166971 E038 0.000000       16 53504329 53504411 83 -