ENSG00000166562

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000587834 ENSG00000166562 HEK293_DMSO_6hA HEK293_OSMI2_6hA SEC11C protein_coding protein_coding 92.52296 48.46968 43.01545 8.126764 3.255921 -0.1721898 79.704386 36.279938 35.383325 6.828147 2.7754165 -0.03609226 0.84271250 0.7438667 0.8222333 0.07836667 0.10561169 0.01146086 FALSE  
ENST00000588875 ENSG00000166562 HEK293_DMSO_6hA HEK293_OSMI2_6hA SEC11C protein_coding protein_coding 92.52296 48.46968 43.01545 8.126764 3.255921 -0.1721898 6.870578 6.698378 3.409131 1.284138 0.3731012 -0.97233420 0.08150417 0.1377000 0.0789000 -0.05880000 0.01146086 0.01146086 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000166562 E001 12.1543576 0.0485015198 0.971461750 0.99327255 18 59139476 59139618 143 + 1.106 1.103 -0.010
ENSG00000166562 E002 8.9073143 0.0032746941 0.529307380 0.84466898 18 59139866 59139874 9 + 1.029 0.960 -0.257
ENSG00000166562 E003 17.5592207 0.0407061420 0.945041413 0.98720225 18 59139875 59139883 9 + 1.273 1.260 -0.044
ENSG00000166562 E004 18.1948465 0.0500207153 0.973376061 0.99373409 18 59139884 59139887 4 + 1.279 1.282 0.008
ENSG00000166562 E005 19.7832353 0.0286478037 0.879261572 0.97097568 18 59139888 59139892 5 + 1.327 1.306 -0.073
ENSG00000166562 E006 22.5328010 0.0311769998 0.779717907 0.94224311 18 59139893 59139898 6 + 1.390 1.354 -0.126
ENSG00000166562 E007 196.9155837 0.0013594846 0.009328925 0.16809659 18 59139899 59140035 137 + 2.337 2.259 -0.260
ENSG00000166562 E008 0.7946133 0.5073171372 0.573303664   18 59140036 59140051 16 + 0.133 0.327 1.651
ENSG00000166562 E009 3.9636479 0.0711287951 0.091537937 0.44112895 18 59146983 59147294 312 + 0.493 0.792 1.296
ENSG00000166562 E010 7.5864743 0.0038267634 0.003019455 0.09892283 18 59147295 59148012 718 + 0.683 1.047 1.410
ENSG00000166562 E011 146.9730624 0.0003340052 0.096315814 0.45047848 18 59149513 59149524 12 + 2.193 2.144 -0.165
ENSG00000166562 E012 280.8247929 0.0001830989 0.065274115 0.38503874 18 59149525 59149622 98 + 2.467 2.428 -0.128
ENSG00000166562 E013 339.0271105 0.0002063770 0.689717115 0.91167657 18 59152536 59152612 77 + 2.532 2.524 -0.028
ENSG00000166562 E014 329.1755961 0.0001449215 0.793510877 0.94596127 18 59152613 59152685 73 + 2.518 2.512 -0.019
ENSG00000166562 E015 7.9956316 0.0052437648 0.443748449 0.79981196 18 59152686 59153361 676 + 0.900 0.986 0.325
ENSG00000166562 E016 3.7257203 0.0283990103 0.003206054 0.10194166 18 59155605 59155687 83 + 0.311 0.813 2.396
ENSG00000166562 E017 408.3078711 0.0002733878 0.428459010 0.79109462 18 59155688 59155807 120 + 2.601 2.614 0.042
ENSG00000166562 E018 17.5018507 0.0021190946 0.068438734 0.39231058 18 59155808 59157311 1504 + 1.172 1.322 0.528
ENSG00000166562 E019 209.5593978 0.0003666685 0.150147242 0.53958382 18 59157608 59157665 58 + 2.300 2.334 0.114
ENSG00000166562 E020 251.7361164 0.0002192116 0.002127783 0.08232529 18 59158632 59158832 201 + 2.361 2.426 0.220