ENSG00000166479

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299608 ENSG00000166479 HEK293_DMSO_6hA HEK293_OSMI2_6hA TMX3 protein_coding protein_coding 12.41228 3.297443 1.985644 1.165418 0.1678612 -0.7288621 9.14251285 2.1198627 1.64862623 0.7246742 0.23830750 -0.3607716 0.739266667 0.64680000 0.82133333 0.17453333 0.245704815 0.001106985 FALSE TRUE
ENST00000544714 ENSG00000166479 HEK293_DMSO_6hA HEK293_OSMI2_6hA TMX3 protein_coding processed_transcript 12.41228 3.297443 1.985644 1.165418 0.1678612 -0.7288621 0.03007968 0.0000000 0.10373734 0.0000000 0.10373734 3.5076340 0.008520833 0.00000000 0.06196667 0.06196667 0.741263477 0.001106985 FALSE FALSE
ENST00000562706 ENSG00000166479 HEK293_DMSO_6hA HEK293_OSMI2_6hA TMX3 protein_coding protein_coding 12.41228 3.297443 1.985644 1.165418 0.1678612 -0.7288621 0.26311460 0.2271622 0.04886271 0.0512282 0.04886271 -2.0104485 0.056075000 0.07746667 0.02403333 -0.05343333 0.476561268 0.001106985 FALSE TRUE
ENST00000578765 ENSG00000166479 HEK293_DMSO_6hA HEK293_OSMI2_6hA TMX3 protein_coding retained_intron 12.41228 3.297443 1.985644 1.165418 0.1678612 -0.7288621 0.37631945 0.4242200 0.00000000 0.1724300 0.00000000 -5.4403542 0.030445833 0.12533333 0.00000000 -0.12533333 0.001106985 0.001106985   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000166479 E001 188.2456715 0.008330958 0.3364119556 0.72919840 18 68673688 68676709 3022 - 2.244 2.286 0.139
ENSG00000166479 E002 13.3614631 0.002007697 0.5115020746 0.83563588 18 68676710 68676838 129 - 1.106 1.181 0.268
ENSG00000166479 E003 15.5234027 0.002097366 0.3769356594 0.75800015 18 68676839 68677027 189 - 1.164 1.253 0.314
ENSG00000166479 E004 15.9912899 0.033854407 0.4583479257 0.80766891 18 68677028 68677193 166 - 1.176 1.268 0.326
ENSG00000166479 E005 9.5162987 0.061344899 0.8718754985 0.96870324 18 68679463 68679531 69 - 0.996 1.048 0.192
ENSG00000166479 E006 0.3089214 0.036595698 0.3205316009   18 68679532 68679577 46 - 0.000 0.189 11.673
ENSG00000166479 E007 17.4024788 0.001993234 0.7900458782 0.94500147 18 68680981 68681110 130 - 1.271 1.266 -0.017
ENSG00000166479 E008 0.5124413 0.023823611 0.3893904179   18 68681293 68681322 30 - 0.240 0.105 -1.437
ENSG00000166479 E009 12.7152550 0.002074341 0.2426744232 0.64758318 18 68682925 68682981 57 - 1.186 1.095 -0.326
ENSG00000166479 E010 10.1838159 0.002905129 0.0906938575 0.43982537 18 68684190 68684243 54 - 1.142 0.988 -0.559
ENSG00000166479 E011 9.6554374 0.087283593 0.2479578982 0.65341353 18 68684428 68684485 58 - 1.102 0.967 -0.492
ENSG00000166479 E012 11.5672204 0.106633519 0.2542649702 0.65988447 18 68687667 68687765 99 - 1.160 1.043 -0.421
ENSG00000166479 E013 2.4614767 0.008374413 0.0001308614 0.01587145 18 68687766 68687977 212 - 0.000 0.707 14.542
ENSG00000166479 E014 2.5560837 0.115631379 0.3528331690 0.74166490 18 68688417 68689054 638 - 0.396 0.626 1.113
ENSG00000166479 E015 1.8200325 0.238930569 0.8274646288 0.95628151 18 68689687 68689981 295 - 0.462 0.420 -0.220
ENSG00000166479 E016 0.3529782 0.027712824 0.8119129281   18 68691014 68691294 281 - 0.136 0.105 -0.434
ENSG00000166479 E017 6.0958716 0.022682510 0.0001180031 0.01479851 18 68691295 68691361 67 - 1.081 0.570 -2.024
ENSG00000166479 E018 2.0420905 0.021440049 0.0712855387 0.39830918 18 68696936 68697225 290 - 0.240 0.572 1.886
ENSG00000166479 E019 8.2245260 0.006223810 0.0022540889 0.08456840 18 68697226 68697303 78 - 1.120 0.791 -1.233
ENSG00000166479 E020 0.3340335 0.027442404 0.3116569014   18 68697376 68697930 555 - 0.000 0.189 11.710
ENSG00000166479 E021 0.0000000       18 68697931 68697931 1 -      
ENSG00000166479 E022 14.3556352 0.001994086 0.6731544004 0.90526806 18 68697932 68698031 100 - 1.196 1.174 -0.081
ENSG00000166479 E023 13.7143838 0.002292001 0.9655943328 0.99207068 18 68700405 68700485 81 - 1.164 1.173 0.033
ENSG00000166479 E024 1.3522765 0.012960843 0.3336255926   18 68701616 68701667 52 - 0.240 0.421 1.150
ENSG00000166479 E025 13.1967016 0.014980076 0.3440648062 0.73502571 18 68701745 68701790 46 - 1.090 1.189 0.354
ENSG00000166479 E026 0.1717682 0.055469124 0.6452301573   18 68706280 68706408 129 - 0.000 0.105 10.626
ENSG00000166479 E027 17.7501295 0.002158754 0.1346053642 0.51717685 18 68710021 68710144 124 - 1.186 1.320 0.473
ENSG00000166479 E028 9.9844646 0.002663491 0.9455022562 0.98733397 18 68711364 68711403 40 - 1.039 1.045 0.023
ENSG00000166479 E029 9.1451049 0.003204433 0.3964807639 0.77077450 18 68713846 68713900 55 - 1.053 0.976 -0.283
ENSG00000166479 E030 0.0000000       18 68714263 68714443 181 -      
ENSG00000166479 E031 7.4874423 0.022982444 0.4069511571 0.77812555 18 68714936 68715108 173 - 0.977 0.877 -0.377