ENSG00000166012

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393259 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding nonsense_mediated_decay 76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 5.913458 3.998527 1.136643 1.5611826 1.1366429 -1.80565584 0.09600417 0.11096667 0.03176667 -0.079200000 0.324534063 0.008169543   FALSE
ENST00000448108 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding protein_coding 76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 7.005053 2.296221 2.868210 0.6845549 0.7291322 0.31964127 0.08541667 0.06843333 0.09403333 0.025600000 0.716273842 0.008169543 FALSE TRUE
ENST00000525928 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding retained_intron 76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 8.765903 4.345178 3.611703 1.4760399 0.1081881 -0.26606319 0.11402083 0.12643333 0.12376667 -0.002666667 0.987642884 0.008169543   FALSE
ENST00000529435 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding retained_intron 76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 7.988362 2.981243 3.279521 0.6890920 0.7896322 0.13713255 0.10520000 0.09183333 0.10896667 0.017133333 0.812317213 0.008169543 TRUE FALSE
ENST00000530769 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding retained_intron 76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 4.989936 2.163192 1.386195 0.7166358 0.1837448 -0.63831512 0.05816667 0.06253333 0.04783333 -0.014700000 0.721347875 0.008169543 TRUE FALSE
ENST00000534079 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding retained_intron 76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 5.575684 3.054476 1.954153 1.0843878 0.1492454 -0.64173326 0.07508750 0.08783333 0.06746667 -0.020366667 0.689072725 0.008169543   FALSE
MSTRG.6184.3 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding   76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 10.446362 3.223686 6.395701 1.0730361 1.0697844 0.98617676 0.13979167 0.09326667 0.21433333 0.121066667 0.008169543 0.008169543 TRUE TRUE
MSTRG.6184.9 ENSG00000166012 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAF1D protein_coding   76.47133 35.04988 29.61225 12.41277 3.124711 -0.24314 4.751620 2.887463 2.793804 1.2457478 0.5643883 -0.04740488 0.06640000 0.08043333 0.09403333 0.013600000 0.801545053 0.008169543 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000166012 E001 2.4282240 0.0092288371 6.486428e-01 0.895938760 11 93729948 93730193 246 - 0.485 0.561 0.359
ENSG00000166012 E002 0.4465501 0.0217681645 6.633981e-01   11 93730194 93730199 6 - 0.128 0.200 0.779
ENSG00000166012 E003 9.7930980 0.0027908097 6.188986e-01 0.883480527 11 93730200 93730271 72 - 1.010 1.063 0.191
ENSG00000166012 E004 9.3790501 0.0027914298 3.584009e-01 0.745700683 11 93730272 93730280 9 - 0.964 1.063 0.361
ENSG00000166012 E005 10.0488154 0.0048522570 1.881187e-01 0.589468423 11 93730281 93730281 1 - 0.964 1.104 0.512
ENSG00000166012 E006 10.2738485 0.0069128973 3.061542e-01 0.704784461 11 93730282 93730282 1 - 0.995 1.104 0.398
ENSG00000166012 E007 56.7896811 0.0018297033 2.147914e-01 0.619426462 11 93730283 93730353 71 - 1.732 1.795 0.214
ENSG00000166012 E008 100.6147600 0.0031601061 1.184595e-01 0.490929417 11 93730354 93730402 49 - 1.973 2.040 0.225
ENSG00000166012 E009 81.5755940 0.0007113407 5.309286e-02 0.352913446 11 93730403 93730405 3 - 1.878 1.956 0.261
ENSG00000166012 E010 117.4794562 0.0003525105 6.176537e-02 0.376275759 11 93730406 93730447 42 - 2.045 2.106 0.205
ENSG00000166012 E011 14.2918872 0.0019272039 3.700653e-02 0.303908698 11 93730448 93730512 65 - 1.065 1.255 0.678
ENSG00000166012 E012 24.2877639 0.0030775894 2.192488e-04 0.021596225 11 93730513 93730666 154 - 1.216 1.501 0.992
ENSG00000166012 E013 13.8244637 0.0091503366 3.365441e-03 0.104512340 11 93730667 93730676 10 - 0.966 1.281 1.132
ENSG00000166012 E014 106.3484218 0.0002880736 2.555327e-02 0.260514345 11 93730677 93730681 5 - 1.989 2.066 0.258
ENSG00000166012 E015 144.3498082 0.0005926830 6.201735e-02 0.376939088 11 93730682 93730712 31 - 2.129 2.188 0.198
ENSG00000166012 E016 57.4196397 0.0255060532 1.421358e-02 0.204082675 11 93730713 93730978 266 - 1.626 1.842 0.730
ENSG00000166012 E017 33.9416105 0.0130434530 1.026945e-02 0.175636314 11 93730979 93731145 167 - 1.407 1.620 0.728
ENSG00000166012 E018 13.3670671 0.0107299859 6.794688e-04 0.043661349 11 93731146 93731149 4 - 0.915 1.275 1.305
ENSG00000166012 E019 117.4766173 0.0002595168 3.232004e-01 0.719332908 11 93731150 93731160 11 - 2.059 2.092 0.108
ENSG00000166012 E020 168.2578216 0.0003056491 1.166720e-01 0.487549843 11 93731161 93731216 56 - 2.206 2.249 0.144
ENSG00000166012 E021 166.4131018 0.0002463900 8.528707e-01 0.963547610 11 93731753 93731799 47 - 2.223 2.228 0.018
ENSG00000166012 E022 9.5758998 0.0589081005 6.804738e-02 0.391403301 11 93731800 93732003 204 - 0.852 1.122 1.002
ENSG00000166012 E023 10.1070521 0.0580754841 1.258857e-01 0.503871955 11 93732004 93732243 240 - 0.909 1.131 0.816
ENSG00000166012 E024 182.7830219 0.0002008163 3.021234e-01 0.701577285 11 93732244 93732291 48 - 2.282 2.255 -0.088
ENSG00000166012 E025 29.0529609 0.0103349673 4.342657e-01 0.793976567 11 93732292 93732313 22 - 1.450 1.501 0.175
ENSG00000166012 E026 26.9443035 0.0020230197 6.847910e-01 0.909953402 11 93732314 93732360 47 - 1.463 1.433 -0.106
ENSG00000166012 E027 67.2590704 0.0104614208 6.591112e-02 0.386598413 11 93732361 93732799 439 - 1.766 1.875 0.367
ENSG00000166012 E028 26.1320973 0.0151178268 2.260888e-01 0.631185997 11 93732800 93732976 177 - 1.368 1.478 0.381
ENSG00000166012 E029 22.5803943 0.0527196939 2.786144e-01 0.681906927 11 93732977 93733086 110 - 1.296 1.413 0.407
ENSG00000166012 E030 138.2382553 0.0006237141 3.693347e-01 0.753196453 11 93733087 93733121 35 - 2.162 2.132 -0.100
ENSG00000166012 E031 33.6336019 0.0009175282 4.400585e-02 0.326441001 11 93733122 93733227 106 - 1.473 1.595 0.417
ENSG00000166012 E032 29.2188882 0.0009635800 1.420523e-01 0.528178929 11 93733228 93733304 77 - 1.426 1.522 0.327
ENSG00000166012 E033 25.8219281 0.0011534095 1.257583e-01 0.503664298 11 93733305 93733349 45 - 1.367 1.473 0.367
ENSG00000166012 E034 149.3497912 0.0002254870 3.140746e-01 0.711487608 11 93733350 93733397 48 - 2.195 2.167 -0.094
ENSG00000166012 E035 63.0534533 0.0059414483 8.889868e-01 0.973485211 11 93733398 93733419 22 - 1.803 1.810 0.024
ENSG00000166012 E036 58.2950411 0.0007812528 2.308039e-01 0.635774344 11 93733420 93733465 46 - 1.741 1.796 0.186
ENSG00000166012 E037 50.6870797 0.0049013405 2.953046e-01 0.695815744 11 93733466 93733505 40 - 1.687 1.739 0.176
ENSG00000166012 E038 80.6021472 0.0023207899 9.674719e-02 0.451366573 11 93733506 93733673 168 - 1.874 1.942 0.231
ENSG00000166012 E039 160.5915680 0.0040162254 1.607024e-02 0.215326270 11 93733674 93734624 951 - 2.147 2.246 0.329
ENSG00000166012 E040 98.0932718 0.0021742796 2.945543e-02 0.277299732 11 93734625 93734660 36 - 2.041 1.954 -0.290
ENSG00000166012 E041 91.5720049 0.0007339897 5.150090e-01 0.837635397 11 93734661 93734962 302 - 1.979 1.954 -0.082
ENSG00000166012 E042 95.1420795 0.0024753464 7.808779e-01 0.942493537 11 93734963 93735110 148 - 1.974 1.986 0.041
ENSG00000166012 E043 101.0350559 0.0078227753 8.602818e-01 0.965750360 11 93735111 93735566 456 - 2.003 2.007 0.014
ENSG00000166012 E044 38.2233686 0.0085036544 7.033991e-01 0.916403090 11 93735567 93735914 348 - 1.573 1.608 0.118
ENSG00000166012 E045 48.7214412 0.0103796807 5.890333e-01 0.870940965 11 93735915 93736140 226 - 1.725 1.687 -0.129
ENSG00000166012 E046 136.5625666 0.0061900760 4.103553e-02 0.317502769 11 93736141 93736289 149 - 2.197 2.094 -0.345
ENSG00000166012 E047 66.8386509 0.0110252027 2.011813e-01 0.604771921 11 93736290 93736304 15 - 1.880 1.798 -0.279
ENSG00000166012 E048 22.6949905 0.0281940483 3.834044e-01 0.762515546 11 93736305 93736693 389 - 1.322 1.397 0.262
ENSG00000166012 E049 98.0466857 0.0028012252 4.310570e-03 0.117876027 11 93736694 93736751 58 - 2.066 1.943 -0.412
ENSG00000166012 E050 26.4081169 0.0210207339 5.831908e-01 0.868174466 11 93736752 93737063 312 - 1.402 1.460 0.200
ENSG00000166012 E051 70.4190534 0.0005097765 5.196156e-03 0.129059189 11 93737064 93737088 25 - 1.921 1.806 -0.388
ENSG00000166012 E052 87.9846761 0.0089665554 4.391086e-02 0.326273453 11 93737089 93737155 67 - 2.012 1.896 -0.389
ENSG00000166012 E053 92.9460622 0.0046210964 2.698513e-02 0.266863238 11 93737156 93737239 84 - 2.028 1.921 -0.359
ENSG00000166012 E054 172.6493274 0.0033825872 5.521873e-05 0.009601512 11 93738109 93738440 332 - 2.319 2.167 -0.507
ENSG00000166012 E055 72.6375120 0.0006596442 8.173130e-07 0.000488939 11 93738441 93738499 59 - 1.975 1.771 -0.687
ENSG00000166012 E056 3.1528014 0.0069642431 8.228317e-02 0.422567935 11 93738967 93739236 270 - 0.434 0.708 1.259
ENSG00000166012 E057 62.5138016 0.0005263793 1.341155e-04 0.016104455 11 93739237 93739280 44 - 1.894 1.726 -0.568
ENSG00000166012 E058 61.0511035 0.0005140210 3.708966e-03 0.109319661 11 93739281 93739331 51 - 1.865 1.735 -0.437
ENSG00000166012 E059 61.3225457 0.0019916515 3.822075e-05 0.007365929 11 93741322 93741495 174 - 1.899 1.696 -0.687
ENSG00000166012 E060 0.6680670 0.0257237935 5.496134e-02   11 93742703 93742898 196 - 0.000 0.337 11.330
ENSG00000166012 E061 0.5153046 0.9153874776 3.978054e-01   11 93766187 93766226 40 - 0.000 0.277 10.932
ENSG00000166012 E062 1.7697506 0.0147757902 5.090478e-01 0.834249987 11 93784304 93784521 218 - 0.375 0.485 0.585