ENSG00000165732

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354185 ENSG00000165732 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX21 protein_coding protein_coding 104.6555 23.0952 31.14721 7.842358 8.114615 0.4313485 94.086341 18.770934 27.463256 6.5974031 7.0779889 0.548759095 0.88679583 0.80670000 0.8841333 0.07743333 0.002083694 0.002083694 FALSE  
ENST00000685106 ENSG00000165732 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX21 protein_coding protein_coding 104.6555 23.0952 31.14721 7.842358 8.114615 0.4313485 5.597154 1.724703 1.732426 0.4713221 0.9151752 0.006408288 0.05817917 0.07766667 0.0445000 -0.03316667 0.722377469 0.002083694 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000165732 E001 0.3089214 0.0438328444 0.1551591577   10 68948052 68948140 89 + 0.000 0.238 11.956
ENSG00000165732 E002 0.4214379 0.0264279002 0.4450065601   10 68948141 68948168 28 + 0.105 0.239 1.421
ENSG00000165732 E003 1.7004332 0.0969477111 0.2398855604 0.64504509 10 68955758 68955993 236 + 0.318 0.552 1.252
ENSG00000165732 E004 1.7227431 0.0965307414 0.5289209624 0.84451326 10 68955994 68956084 91 + 0.372 0.506 0.702
ENSG00000165732 E005 1.5403680 0.0117740194 0.8067494043   10 68956085 68956134 50 + 0.422 0.392 -0.164
ENSG00000165732 E006 1.4184095 0.0148320473 0.4921565234   10 68956135 68956137 3 + 0.321 0.452 0.743
ENSG00000165732 E007 6.4077833 0.0036091082 0.1256602919 0.50350714 10 68956138 68956159 22 + 0.773 0.974 0.774
ENSG00000165732 E008 9.6128681 0.0026597467 0.5454258177 0.85220180 10 68956160 68956169 10 + 1.001 1.079 0.284
ENSG00000165732 E009 12.8282498 0.0020218930 0.7216676692 0.92269059 10 68956170 68956175 6 + 1.124 1.174 0.177
ENSG00000165732 E010 125.6799058 0.0016491225 0.0399730034 0.31391339 10 68956176 68956312 137 + 2.133 2.079 -0.179
ENSG00000165732 E011 0.3535412 0.9297794003 0.5059200355   10 68956399 68956410 12 + 0.202 0.000 -12.666
ENSG00000165732 E012 1.7388856 0.0102399846 0.6243553228 0.88578301 10 68956411 68956514 104 + 0.465 0.392 -0.387
ENSG00000165732 E013 3.1933136 0.0458497545 0.9815096854 0.99558806 10 68956515 68956748 234 + 0.629 0.634 0.021
ENSG00000165732 E014 348.3102796 0.0001443477 0.0074683830 0.15212196 10 68959806 68960249 444 + 2.564 2.533 -0.103
ENSG00000165732 E015 121.0444445 0.0030123145 0.1887784203 0.59011669 10 68962082 68962157 76 + 2.113 2.069 -0.147
ENSG00000165732 E016 213.7294691 0.0002094640 0.0034238318 0.10528555 10 68963291 68963469 179 + 2.363 2.310 -0.176
ENSG00000165732 E017 174.0633179 0.0018713621 0.3637128994 0.74944486 10 68965377 68965494 118 + 2.258 2.241 -0.055
ENSG00000165732 E018 232.8616447 0.0070551227 0.2765125139 0.68028770 10 68967018 68967203 186 + 2.388 2.353 -0.117
ENSG00000165732 E019 206.1267496 0.0078722538 0.8392809227 0.95998842 10 68968976 68969121 146 + 2.321 2.318 -0.010
ENSG00000165732 E020 206.2156936 0.0068117402 0.2986697343 0.69888585 10 68970201 68970350 150 + 2.335 2.299 -0.118
ENSG00000165732 E021 0.1795728 0.0563325582 0.3914654814   10 68970992 68970995 4 + 0.000 0.136 12.480
ENSG00000165732 E022 0.1795728 0.0563325582 0.3914654814   10 68970996 68970996 1 + 0.000 0.136 12.480
ENSG00000165732 E023 0.7995283 0.0169872862 0.4704913482   10 68970997 68971066 70 + 0.190 0.322 1.005
ENSG00000165732 E024 3.9616451 0.0723407375 0.6579880838 0.89993886 10 68971067 68971890 824 + 0.639 0.732 0.390
ENSG00000165732 E025 89.9722590 0.0038382694 0.2478453583 0.65332877 10 68971891 68971899 9 + 1.977 1.943 -0.114
ENSG00000165732 E026 202.8886878 0.0042790962 0.0602562937 0.37221390 10 68971900 68972052 153 + 2.330 2.285 -0.152
ENSG00000165732 E027 28.4788004 0.0814112160 0.0008051508 0.04770137 10 68972053 68973544 1492 + 1.143 1.678 1.854
ENSG00000165732 E028 173.0295985 0.0028492427 0.0203261276 0.23762454 10 68973545 68973664 120 + 2.268 2.209 -0.197
ENSG00000165732 E029 130.8383591 0.0003586713 0.9475558630 0.98771777 10 68974670 68974743 74 + 2.116 2.134 0.061
ENSG00000165732 E030 157.6606257 0.0003295834 0.9448986760 0.98712981 10 68977529 68977643 115 + 2.195 2.217 0.073
ENSG00000165732 E031 120.2839836 0.0007776223 0.8502593200 0.96311192 10 68977644 68977688 45 + 2.076 2.103 0.093
ENSG00000165732 E032 214.4063693 0.0024573169 0.7868411433 0.94422590 10 68978842 68978976 135 + 2.331 2.345 0.048
ENSG00000165732 E033 6.5679895 0.2958756665 0.0303162577 0.28077782 10 68978977 68979120 144 + 0.531 1.089 2.232
ENSG00000165732 E034 24.3282914 0.2223708338 0.0220602973 0.24573537 10 68979121 68980810 1690 + 1.090 1.606 1.801
ENSG00000165732 E035 142.0065599 0.0056285316 0.8387387884 0.95978085 10 68981537 68981581 45 + 2.155 2.163 0.028
ENSG00000165732 E036 2158.4769871 0.0014579825 0.0010866334 0.05674670 10 68982543 68985068 2526 + 3.307 3.364 0.188