ENSG00000165283

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356493 ENSG00000165283 HEK293_DMSO_6hA HEK293_OSMI2_6hA STOML2 protein_coding protein_coding 381.3207 374.9587 435.7795 41.20429 52.76876 0.2168611 244.79326 207.75419 324.79312 27.1513105 51.372874 0.6446185 0.619375 0.55163333 0.73763333 0.18600000 1.318840e-04 3.616893e-08 FALSE TRUE
ENST00000487490 ENSG00000165283 HEK293_DMSO_6hA HEK293_OSMI2_6hA STOML2 protein_coding processed_transcript 381.3207 374.9587 435.7795 41.20429 52.76876 0.2168611 18.51932 28.28615 15.37386 0.3465962 3.937131 -0.8791885 0.058775 0.07776667 0.03893333 -0.03883333 2.281287e-01 3.616893e-08   FALSE
MSTRG.32608.4 ENSG00000165283 HEK293_DMSO_6hA HEK293_OSMI2_6hA STOML2 protein_coding   381.3207 374.9587 435.7795 41.20429 52.76876 0.2168611 98.89378 113.15695 76.40676 14.6271992 7.795731 -0.5664916 0.266950 0.30176667 0.17646667 -0.12530000 3.616893e-08 3.616893e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000165283 E001 0.7048822 1.116894e-01 9.618908e-01   9 35099776 35099777 2 - 0.209 0.220 0.092
ENSG00000165283 E002 2.1516783 9.347905e-03 4.892147e-01 0.824189521 9 35099778 35099890 113 - 0.538 0.423 -0.573
ENSG00000165283 E003 29.0622856 1.927969e-03 3.461575e-01 0.736202327 9 35099891 35099893 3 - 1.510 1.447 -0.217
ENSG00000165283 E004 31.6668935 2.862522e-03 3.116850e-01 0.709487322 9 35099894 35099894 1 - 1.549 1.482 -0.230
ENSG00000165283 E005 33.1086872 1.891200e-03 2.851328e-01 0.687649401 9 35099895 35099895 1 - 1.568 1.500 -0.231
ENSG00000165283 E006 769.3141930 1.869528e-03 6.954360e-02 0.394653819 9 35099896 35100005 110 - 2.862 2.905 0.143
ENSG00000165283 E007 978.8423260 1.202310e-04 4.341630e-03 0.118215702 9 35100006 35100024 19 - 2.967 3.002 0.114
ENSG00000165283 E008 3511.8450748 1.682798e-04 3.776989e-03 0.110007894 9 35100025 35100172 148 - 3.529 3.553 0.080
ENSG00000165283 E009 3846.0144040 7.207560e-05 3.473600e-01 0.737190602 9 35100598 35100726 129 - 3.577 3.583 0.021
ENSG00000165283 E010 107.8570853 1.263521e-01 2.556352e-02 0.260571196 9 35100727 35100931 205 - 1.840 2.166 1.093
ENSG00000165283 E011 2679.6946969 1.971815e-04 8.938251e-01 0.974637715 9 35100932 35101011 80 - 3.423 3.425 0.008
ENSG00000165283 E012 4534.7193632 3.703900e-05 5.585555e-01 0.857493350 9 35101135 35101279 145 - 3.653 3.649 -0.012
ENSG00000165283 E013 2448.0176045 3.841516e-04 9.238182e-02 0.442912546 9 35101426 35101449 24 - 3.375 3.396 0.069
ENSG00000165283 E014 3862.9213271 3.264475e-05 4.795413e-01 0.818898870 9 35101450 35101560 111 - 3.584 3.579 -0.015
ENSG00000165283 E015 3330.6703480 3.507582e-05 1.879291e-01 0.589121329 9 35101710 35101780 71 - 3.521 3.512 -0.030
ENSG00000165283 E016 2639.3344175 2.331521e-04 8.230458e-01 0.955281605 9 35101781 35101811 31 - 3.419 3.416 -0.010
ENSG00000165283 E017 2902.6920246 1.286970e-04 7.914255e-01 0.945477950 9 35101904 35101962 59 - 3.457 3.459 0.005
ENSG00000165283 E018 3133.4425597 5.853574e-04 3.709703e-01 0.753984788 9 35102095 35102194 100 - 3.500 3.488 -0.038
ENSG00000165283 E019 149.0823934 1.000183e-01 3.718119e-02 0.304530408 9 35102195 35102364 170 - 2.018 2.287 0.900
ENSG00000165283 E020 2522.5214601 6.724605e-04 6.989433e-04 0.044391808 9 35102686 35102823 138 - 3.423 3.377 -0.155
ENSG00000165283 E021 54.9091100 2.790219e-02 7.171606e-02 0.399175727 9 35102910 35102946 37 - 1.647 1.819 0.582
ENSG00000165283 E022 38.0712281 1.075927e-02 8.360834e-02 0.425002457 9 35102947 35102953 7 - 1.512 1.643 0.448
ENSG00000165283 E023 78.4909523 2.430532e-02 1.740605e-01 0.571742730 9 35102954 35103049 96 - 1.838 1.947 0.366
ENSG00000165283 E024 1100.6340270 1.290424e-03 1.555876e-05 0.004176254 9 35103050 35103160 111 - 3.083 2.995 -0.292
ENSG00000165283 E025 35.4294476 2.359284e-02 8.767649e-01 0.970353234 9 35103161 35103258 98 - 1.577 1.554 -0.076