ENSG00000164970

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297620 ENSG00000164970 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM219A protein_coding protein_coding 12.23456 15.73207 18.69014 1.20475 2.101366 0.2484239 3.6525365 4.4740508 6.130803 0.3947380 2.0600738 0.45362461 0.30151667 0.28866667 0.31743333 0.028766667 9.260261e-01 3.688341e-05 FALSE  
ENST00000379080 ENSG00000164970 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM219A protein_coding protein_coding 12.23456 15.73207 18.69014 1.20475 2.101366 0.2484239 0.4745057 0.0000000 1.727672 0.0000000 0.6758696 7.44101233 0.04003333 0.00000000 0.09653333 0.096533333 3.688341e-05 3.688341e-05 FALSE  
ENST00000379081 ENSG00000164970 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM219A protein_coding protein_coding 12.23456 15.73207 18.69014 1.20475 2.101366 0.2484239 1.2079839 1.5352029 1.490885 0.7856193 0.7796309 -0.04198244 0.09442500 0.10296667 0.07390000 -0.029066667 9.830322e-01 3.688341e-05 FALSE  
ENST00000379087 ENSG00000164970 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM219A protein_coding protein_coding 12.23456 15.73207 18.69014 1.20475 2.101366 0.2484239 1.5654439 2.4162694 2.390946 1.3148544 0.6517641 -0.01513678 0.11775833 0.14200000 0.13273333 -0.009266667 9.123756e-01 3.688341e-05 FALSE  
ENST00000379089 ENSG00000164970 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM219A protein_coding protein_coding 12.23456 15.73207 18.69014 1.20475 2.101366 0.2484239 0.9035331 0.8920915 0.000000 0.8920915 0.0000000 -6.49520188 0.08099167 0.06656667 0.00000000 -0.066566667 7.742310e-01 3.688341e-05 FALSE  
ENST00000445726 ENSG00000164970 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM219A protein_coding protein_coding 12.23456 15.73207 18.69014 1.20475 2.101366 0.2484239 3.3165696 3.5438694 6.794982 2.0262271 0.8369750 0.93720075 0.29046250 0.22403333 0.37006667 0.146033333 7.663088e-01 3.688341e-05 FALSE  
ENST00000651358 ENSG00000164970 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM219A protein_coding protein_coding 12.23456 15.73207 18.69014 1.20475 2.101366 0.2484239 1.0614051 2.8002819 0.000000 2.8002819 0.0000000 -8.13457106 0.07022083 0.17120000 0.00000000 -0.171200000 8.758768e-01 3.688341e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000164970 E001 1.138150 0.2943198592 1.159677e-01   9 34398184 34398184 1 - 0.117 0.472 2.674
ENSG00000164970 E002 4.594086 0.0046134693 9.385505e-01 0.9856090370 9 34398185 34398189 5 - 0.742 0.753 0.044
ENSG00000164970 E003 125.289181 0.0010240691 5.901403e-01 0.8714359618 9 34398190 34398344 155 - 2.093 2.111 0.059
ENSG00000164970 E004 1545.092580 0.0001166382 1.116257e-06 0.0006186416 9 34398345 34401012 2668 - 3.173 3.203 0.100
ENSG00000164970 E005 70.617033 0.0063504966 1.107978e-01 0.4771237456 9 34401013 34401027 15 - 1.893 1.806 -0.292
ENSG00000164970 E006 114.485821 0.0003101616 4.368782e-03 0.1185988714 9 34401028 34401119 92 - 2.103 2.011 -0.308
ENSG00000164970 E007 49.810801 0.0005856904 1.032344e-02 0.1760690712 9 34401120 34401122 3 - 1.765 1.640 -0.425
ENSG00000164970 E008 107.223508 0.0002747842 8.954391e-04 0.0508626726 9 34401666 34401720 55 - 2.085 1.974 -0.371
ENSG00000164970 E009 1.680258 0.0473263302 2.059224e-01 0.6097328669 9 34402250 34402386 137 - 0.532 0.301 -1.264
ENSG00000164970 E010 132.749326 0.0002211038 1.752809e-01 0.5730728662 9 34402387 34402467 81 - 2.144 2.105 -0.133
ENSG00000164970 E011 121.562928 0.0002887342 8.428955e-01 0.9609919388 9 34402705 34402807 103 - 2.085 2.092 0.024
ENSG00000164970 E012 35.970446 0.0043981847 7.258065e-01 0.9242859435 9 34405865 34405915 51 - 1.547 1.573 0.087
ENSG00000164970 E013 58.514239 0.0010100485 4.681655e-01 0.8129842302 9 34405916 34405964 49 - 1.787 1.756 -0.106
ENSG00000164970 E014 33.497444 0.0029743836 7.074246e-01 0.9178551672 9 34458204 34458236 33 - 1.548 1.528 -0.070
ENSG00000164970 E015 46.161723 0.0023068958 1.502257e-01 0.5396786865 9 34458237 34458570 334 - 1.706 1.630 -0.258