ENSG00000163811

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296126 ENSG00000163811 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR43 protein_coding protein_coding 42.16895 10.48811 9.851581 3.20106 1.229366 -0.09023917 5.741388 0.0000000 0.0000000 0.0000000 0.0000000 0.000000 0.07880417 0.0000000 0.00000000 0.00000000   7.186246e-06 FALSE FALSE
ENST00000407426 ENSG00000163811 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR43 protein_coding protein_coding 42.16895 10.48811 9.851581 3.20106 1.229366 -0.09023917 32.144652 8.8466927 9.7134483 2.9867332 1.3371274 0.134700 0.80671250 0.8296667 0.98223333 0.15256667 9.176422e-03 7.186246e-06 FALSE TRUE
ENST00000446643 ENSG00000163811 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR43 protein_coding processed_transcript 42.16895 10.48811 9.851581 3.20106 1.229366 -0.09023917 0.875005 0.9670289 0.1381323 0.2728589 0.1107267 -2.721515 0.05206667 0.1112333 0.01776667 -0.09346667 2.463738e-01 7.186246e-06 FALSE TRUE
ENST00000466067 ENSG00000163811 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR43 protein_coding retained_intron 42.16895 10.48811 9.851581 3.20106 1.229366 -0.09023917 1.867533 0.6743910 0.0000000 0.3077815 0.0000000 -6.096749 0.03554583 0.0591000 0.00000000 -0.05910000 7.186246e-06 7.186246e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000163811 E001 53.8620706 0.0007025200 0.156293792 0.54839852 2 28894667 28894923 257 + 1.774 1.719 -0.184
ENSG00000163811 E002 0.0000000       2 28895086 28895353 268 +      
ENSG00000163811 E003 0.0000000       2 28895804 28895861 58 +      
ENSG00000163811 E004 0.5074389 0.0213316097 0.574893592   2 28896920 28896998 79 + 0.118 0.216 1.037
ENSG00000163811 E005 63.1261467 0.0004528192 0.521713150 0.84091281 2 28901987 28902124 138 + 1.820 1.806 -0.046
ENSG00000163811 E006 0.3591457 0.6812354867 0.355797055   2 28905006 28905051 46 + 0.000 0.219 10.209
ENSG00000163811 E007 74.1182367 0.0004624687 0.152958713 0.54340613 2 28906460 28906581 122 + 1.903 1.861 -0.143
ENSG00000163811 E008 86.4387801 0.0003486047 0.284350949 0.68708368 2 28912590 28912710 121 + 1.960 1.935 -0.085
ENSG00000163811 E009 96.6882051 0.0019413234 0.364614447 0.75005986 2 28914069 28914208 140 + 2.006 1.988 -0.060
ENSG00000163811 E010 76.1481297 0.0004950286 0.240118920 0.64523758 2 28917893 28917995 103 + 1.912 1.880 -0.107
ENSG00000163811 E011 58.4953081 0.0007232065 0.418435061 0.78540077 2 28922919 28922983 65 + 1.792 1.769 -0.076
ENSG00000163811 E012 86.3134431 0.0014471496 0.354176698 0.74262336 2 28924982 28925096 115 + 1.960 1.936 -0.080
ENSG00000163811 E013 58.2239827 0.0004738560 0.964258588 0.99181604 2 28925097 28925153 57 + 1.772 1.783 0.040
ENSG00000163811 E014 80.8463432 0.0008607337 0.607110692 0.87849688 2 28926468 28926554 87 + 1.923 1.916 -0.022
ENSG00000163811 E015 103.9390739 0.0008724164 0.414508214 0.78309648 2 28927569 28927700 132 + 2.036 2.020 -0.055
ENSG00000163811 E016 102.6608172 0.0016465183 0.803232978 0.94923003 2 28929579 28929710 132 + 2.022 2.026 0.011
ENSG00000163811 E017 2.7086932 0.0267295485 0.491468871 0.82523524 2 28930058 28930149 92 + 0.504 0.624 0.554
ENSG00000163811 E018 74.0055343 0.0038046631 0.959471555 0.99066184 2 28935521 28935607 87 + 1.879 1.890 0.039
ENSG00000163811 E019 2.2818429 0.0341245123 0.001411505 0.06592333 2 28935608 28935740 133 + 0.118 0.712 3.730
ENSG00000163811 E020 66.1176299 0.0004951076 0.545529279 0.85224210 2 28936922 28936953 32 + 1.813 1.853 0.135
ENSG00000163811 E021 80.7160520 0.0003567678 0.529517051 0.84470540 2 28937931 28937994 64 + 1.923 1.913 -0.033
ENSG00000163811 E022 114.5266904 0.0003268256 0.459649419 0.80842293 2 28941461 28941574 114 + 2.070 2.061 -0.032
ENSG00000163811 E023 111.4544626 0.0007707776 0.595789114 0.87383754 2 28942312 28942381 70 + 2.038 2.069 0.104
ENSG00000163811 E024 99.1849932 0.0046243580 0.872076370 0.96879251 2 28946450 28946499 50 + 1.994 2.009 0.050
ENSG00000163811 E025 430.2934355 0.0056260743 0.024969217 0.25850151 2 28946600 28948219 1620 + 2.593 2.670 0.258