ENSG00000163681

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000417128 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding protein_coding 15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 0.4909789 0.5827997 0.5820032 0.3400916 0.58200323 -0.001939552 0.04393750 0.11236667 0.05710000 -0.05526667 0.7069051159 0.0009685768 FALSE TRUE
ENST00000449503 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding protein_coding 15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 0.7063249 0.4201244 0.4103105 0.2400999 0.41031049 -0.033298487 0.05524167 0.10090000 0.04133333 -0.05956667 0.7272274575 0.0009685768 FALSE TRUE
ENST00000460223 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding protein_coding 15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 0.3293547 0.0000000 0.5464300 0.0000000 0.33936525 5.798128247 0.04105000 0.00000000 0.07850000 0.07850000 0.3374806190 0.0009685768   FALSE
ENST00000494088 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding protein_coding 15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 3.2961582 0.8547116 1.5845521 0.1965083 0.50679453 0.882860283 0.20097500 0.19050000 0.20130000 0.01080000 0.9855887705 0.0009685768 FALSE TRUE
ENST00000497084 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding retained_intron 15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 0.6877936 0.6852657 0.2757006 0.2604446 0.07672898 -1.283060141 0.05211250 0.14053333 0.04673333 -0.09380000 0.2850087749 0.0009685768 FALSE FALSE
ENST00000671191 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding protein_coding 15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 1.3050621 0.4931344 0.4246974 0.3299135 0.21401583 -0.210932483 0.08240833 0.08436667 0.04226667 -0.04210000 0.8525027098 0.0009685768 FALSE TRUE
MSTRG.23147.3 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding   15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 1.6076792 0.5163531 1.1433872 0.2341687 0.75163482 1.131773978 0.10988750 0.15043333 0.12406667 -0.02636667 0.9776835520 0.0009685768 FALSE TRUE
MSTRG.23147.4 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding   15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 1.9051924 0.0000000 0.8631386 0.0000000 0.67855739 6.448138732 0.08361250 0.00000000 0.10433333 0.10433333 0.2871380720 0.0009685768 TRUE TRUE
MSTRG.23147.6 ENSG00000163681 HEK293_DMSO_6hA HEK293_OSMI2_6hA SLMAP protein_coding   15.78026 4.712618 8.040773 1.470585 2.022342 0.7695406 1.6732754 0.0000000 0.5161383 0.0000000 0.18860536 5.717370107 0.07737083 0.00000000 0.06010000 0.06010000 0.0009685768 0.0009685768 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000163681 E001 0.0000000       3 57755450 57755485 36 +      
ENSG00000163681 E002 0.4018037 0.0248554108 2.034484e-01   3 57756230 57756263 34 + 0.237 0.000 -10.946
ENSG00000163681 E003 0.8734660 0.2357560403 9.072061e-01   3 57756264 57756273 10 + 0.287 0.263 -0.170
ENSG00000163681 E004 0.8734660 0.2357560403 9.072061e-01   3 57756274 57756281 8 + 0.287 0.263 -0.170
ENSG00000163681 E005 3.0684946 0.0083624272 2.029260e-01 0.606768184 3 57756282 57756308 27 + 0.688 0.487 -0.908
ENSG00000163681 E006 8.7516588 0.0068381792 1.010999e-02 0.174381256 3 57756309 57756342 34 + 1.085 0.775 -1.171
ENSG00000163681 E007 13.1838694 0.0021270423 8.489135e-03 0.160640190 3 57756548 57756596 49 + 1.237 0.986 -0.907
ENSG00000163681 E008 27.3222285 0.0250332156 6.625027e-02 0.387281385 3 57756597 57756931 335 + 1.517 1.311 -0.711
ENSG00000163681 E009 11.9207868 0.0270027507 5.477919e-01 0.853121157 3 57756932 57757012 81 + 1.138 1.055 -0.298
ENSG00000163681 E010 9.1508484 0.0028411763 7.208294e-01 0.922563365 3 57757013 57757067 55 + 1.020 0.986 -0.126
ENSG00000163681 E011 11.6552103 0.0023675337 7.425190e-01 0.930184969 3 57757068 57757119 52 + 1.111 1.085 -0.094
ENSG00000163681 E012 19.1273135 0.0015137091 3.448408e-01 0.735538907 3 57757120 57757235 116 + 1.330 1.263 -0.234
ENSG00000163681 E013 17.4148017 0.0118458803 3.725575e-01 0.755089588 3 57757236 57757300 65 + 1.280 1.211 -0.243
ENSG00000163681 E014 23.3050471 0.0055391366 7.072361e-01 0.917805074 3 57757301 57757446 146 + 1.386 1.367 -0.065
ENSG00000163681 E015 18.0755914 0.0016600203 9.198102e-01 0.980785091 3 57757447 57757553 107 + 1.283 1.283 -0.003
ENSG00000163681 E016 9.0198566 0.0028666781 9.522430e-01 0.988879642 3 57757554 57757557 4 + 0.989 1.004 0.054
ENSG00000163681 E017 34.7523127 0.0108727398 9.290496e-01 0.983083648 3 57757558 57757849 292 + 1.545 1.562 0.058
ENSG00000163681 E018 0.0000000       3 57820613 57820705 93 +      
ENSG00000163681 E019 24.0254389 0.0121490536 8.123267e-01 0.952234169 3 57831383 57831530 148 + 1.387 1.405 0.062
ENSG00000163681 E020 0.6406282 0.0195884995 6.113817e-01   3 57831531 57831536 6 + 0.172 0.262 0.766
ENSG00000163681 E021 22.0062464 0.0131968093 8.127254e-01 0.952324315 3 57841299 57841371 73 + 1.360 1.343 -0.057
ENSG00000163681 E022 22.1729267 0.0196005704 8.844514e-01 0.972317667 3 57847197 57847233 37 + 1.349 1.374 0.087
ENSG00000163681 E023 25.2123697 0.0092395391 5.448342e-01 0.852012789 3 57849754 57849816 63 + 1.430 1.383 -0.164
ENSG00000163681 E024 0.1717682 0.0537572626 3.038737e-01   3 57856560 57856648 89 + 0.000 0.150 12.158
ENSG00000163681 E025 27.8570479 0.0010255348 8.306371e-02 0.424107361 3 57857733 57857828 96 + 1.500 1.390 -0.378
ENSG00000163681 E026 28.1192505 0.0010147543 1.461450e-01 0.533802247 3 57858088 57858159 72 + 1.493 1.404 -0.307
ENSG00000163681 E027 25.1748682 0.0012459323 4.685781e-01 0.813268224 3 57860699 57860759 61 + 1.431 1.390 -0.144
ENSG00000163681 E028 25.7080261 0.0014325388 7.057037e-01 0.917166348 3 57860760 57860839 80 + 1.435 1.418 -0.059
ENSG00000163681 E029 13.1302825 0.0021063380 7.824030e-01 0.942972759 3 57861949 57861953 5 + 1.157 1.140 -0.062
ENSG00000163681 E030 19.1336816 0.0063891211 4.567432e-01 0.806996321 3 57861954 57861999 46 + 1.316 1.263 -0.187
ENSG00000163681 E031 23.6846126 0.0012216042 7.848770e-01 0.943702007 3 57862000 57862086 87 + 1.377 1.404 0.093
ENSG00000163681 E032 14.2219612 0.0017615810 8.054350e-01 0.949766532 3 57864548 57864556 9 + 1.172 1.200 0.102
ENSG00000163681 E033 16.3447801 0.0015536221 8.519081e-01 0.963359907 3 57864557 57864572 16 + 1.231 1.254 0.079
ENSG00000163681 E034 16.8739957 0.0016760639 5.876138e-01 0.870320607 3 57864573 57864585 13 + 1.231 1.283 0.181
ENSG00000163681 E035 30.4488837 0.0009415911 9.086866e-01 0.978152069 3 57864586 57864716 131 + 1.490 1.505 0.051
ENSG00000163681 E036 11.8428620 0.0023666473 7.842900e-01 0.943483535 3 57864807 57864857 51 + 1.119 1.099 -0.071
ENSG00000163681 E037 3.2690116 0.1019381939 9.771406e-01 0.994610580 3 57865242 57865292 51 + 0.615 0.668 0.230
ENSG00000163681 E038 8.9516354 0.0032537540 4.532500e-01 0.805151981 3 57871636 57871698 63 + 1.021 0.947 -0.274
ENSG00000163681 E039 0.2669773 0.0274424043 7.082580e-01   3 57883961 57884026 66 + 0.094 0.150 0.767
ENSG00000163681 E040 0.2842848 0.0283123135 7.025135e-01   3 57889991 57890040 50 + 0.094 0.150 0.769
ENSG00000163681 E041 15.0711470 0.0021430324 4.169296e-02 0.319560508 3 57890041 57890045 5 + 1.277 1.099 -0.633
ENSG00000163681 E042 16.3498787 0.0072854944 1.616285e-01 0.556346990 3 57890046 57890047 2 + 1.295 1.165 -0.460
ENSG00000163681 E043 18.0216179 0.0081228926 3.591822e-01 0.746305465 3 57890048 57890056 9 + 1.316 1.233 -0.291
ENSG00000163681 E044 23.7918633 0.0027198129 5.569112e-01 0.856817063 3 57890057 57890100 44 + 1.414 1.375 -0.134
ENSG00000163681 E045 0.3089214 0.0748010871 1.118792e-01   3 57890101 57891206 1106 + 0.000 0.261 13.004
ENSG00000163681 E046 0.0000000       3 57896239 57896246 8 +      
ENSG00000163681 E047 1.5412695 0.3664527967 3.176857e-01   3 57896247 57896339 93 + 0.322 0.538 1.153
ENSG00000163681 E048 0.7057227 0.0196908636 3.135408e-01   3 57896340 57896340 1 + 0.172 0.350 1.353
ENSG00000163681 E049 0.8601834 0.0264667131 1.590401e-01   3 57896341 57896371 31 + 0.171 0.423 1.769
ENSG00000163681 E050 0.4214379 0.0300279227 3.217263e-01   3 57896372 57896510 139 + 0.094 0.261 1.766
ENSG00000163681 E051 15.9457163 0.0025566866 6.574272e-01 0.899659738 3 57896511 57896518 8 + 1.212 1.254 0.148
ENSG00000163681 E052 27.8012709 0.0010782384 3.739927e-01 0.755894060 3 57896519 57896591 73 + 1.435 1.499 0.221
ENSG00000163681 E053 30.3634021 0.0013135834 8.240939e-01 0.955470251 3 57896873 57896932 60 + 1.506 1.499 -0.023
ENSG00000163681 E054 1.7281276 0.3431953370 5.899546e-01 0.871323725 3 57896933 57902145 5213 + 0.364 0.486 0.657
ENSG00000163681 E055 39.8483862 0.0154189726 3.303060e-01 0.724837816 3 57907884 57908006 123 + 1.639 1.573 -0.226
ENSG00000163681 E056 0.5303118 1.2780184780 6.169886e-01   3 57908168 57908227 60 + 0.258 0.000 -12.304
ENSG00000163681 E057 30.8461971 0.0016614614 6.048094e-02 0.372670788 3 57909076 57909150 75 + 1.552 1.438 -0.391
ENSG00000163681 E058 0.6183183 0.0194217321 1.320168e-01   3 57912295 57912380 86 + 0.094 0.350 2.352
ENSG00000163681 E059 41.7286088 0.0008250686 2.489147e-01 0.654559191 3 57912381 57912503 123 + 1.657 1.600 -0.194
ENSG00000163681 E060 60.6868940 0.0017353908 5.660755e-01 0.860480128 3 57912504 57912701 198 + 1.775 1.807 0.109
ENSG00000163681 E061 51.4732578 0.0005866580 1.602747e-01 0.554735250 3 57913158 57913275 118 + 1.689 1.763 0.253
ENSG00000163681 E062 36.4887134 0.0009422402 6.411099e-01 0.892836128 3 57916906 57916964 59 + 1.562 1.595 0.115
ENSG00000163681 E063 18.6156544 0.0942800937 7.040447e-01 0.916642066 3 57916965 57916980 16 + 1.302 1.264 -0.133
ENSG00000163681 E064 38.3907545 0.0032801721 7.113645e-01 0.919198310 3 57916981 57917077 97 + 1.581 1.613 0.108
ENSG00000163681 E065 6.4093874 0.0040329333 6.816648e-01 0.908789573 3 57917078 57918480 1403 + 0.849 0.904 0.211
ENSG00000163681 E066 50.0012080 0.0041148509 7.082324e-01 0.918083263 3 57922889 57923023 135 + 1.697 1.726 0.101
ENSG00000163681 E067 38.4850900 0.0007285998 3.883446e-01 0.766008843 3 57925845 57925934 90 + 1.614 1.572 -0.141
ENSG00000163681 E068 8.3151056 0.0181355737 4.422964e-06 0.001716452 3 57925935 57926290 356 + 0.621 1.221 2.300
ENSG00000163681 E069 57.4889594 0.0005475678 1.375333e-01 0.521541931 3 57927296 57927513 218 + 1.732 1.807 0.254
ENSG00000163681 E070 251.4804007 0.0041584885 7.108568e-03 0.148382717 3 57927514 57930003 2490 + 2.349 2.456 0.355
ENSG00000163681 E071 0.2920894 0.0275091318 7.032873e-01   3 57931659 57931691 33 + 0.094 0.150 0.769