ENSG00000163608

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314400 ENSG00000163608 HEK293_DMSO_6hA HEK293_OSMI2_6hA NEPRO protein_coding protein_coding 24.30152 8.774509 9.141934 2.323583 1.714355 0.05911499 4.2262191 2.2101693 1.6858131 0.4383746 0.1230823 -0.3886925 0.19506250 0.25980000 0.19490000 -0.06490000 5.998530e-01 1.447548e-05 FALSE TRUE
ENST00000469809 ENSG00000163608 HEK293_DMSO_6hA HEK293_OSMI2_6hA NEPRO protein_coding nonsense_mediated_decay 24.30152 8.774509 9.141934 2.323583 1.714355 0.05911499 0.7468409 0.9079498 0.0000000 0.4682510 0.0000000 -6.5203434 0.05282083 0.09100000 0.00000000 -0.09100000 1.447548e-05 1.447548e-05 FALSE TRUE
ENST00000472637 ENSG00000163608 HEK293_DMSO_6hA HEK293_OSMI2_6hA NEPRO protein_coding nonsense_mediated_decay 24.30152 8.774509 9.141934 2.323583 1.714355 0.05911499 2.4833737 0.1508446 2.2916011 0.1508446 0.5547424 3.8388983 0.15099583 0.02483333 0.24446667 0.21963333 7.170754e-02 1.447548e-05 FALSE TRUE
ENST00000473284 ENSG00000163608 HEK293_DMSO_6hA HEK293_OSMI2_6hA NEPRO protein_coding nonsense_mediated_decay 24.30152 8.774509 9.141934 2.323583 1.714355 0.05911499 5.6440053 0.6783380 1.6465043 0.4367245 0.3588518 1.2669530 0.17353333 0.06350000 0.17803333 0.11453333 4.374289e-01 1.447548e-05 FALSE TRUE
ENST00000474311 ENSG00000163608 HEK293_DMSO_6hA HEK293_OSMI2_6hA NEPRO protein_coding retained_intron 24.30152 8.774509 9.141934 2.323583 1.714355 0.05911499 2.7001056 1.9828890 1.4790552 0.2802658 0.3697292 -0.4204642 0.12642917 0.24246667 0.16520000 -0.07726667 6.701812e-01 1.447548e-05 FALSE TRUE
MSTRG.23436.3 ENSG00000163608 HEK293_DMSO_6hA HEK293_OSMI2_6hA NEPRO protein_coding   24.30152 8.774509 9.141934 2.323583 1.714355 0.05911499 2.7382094 0.2654813 0.7979289 0.2108227 0.4010259 1.5522738 0.09613333 0.04023333 0.07376667 0.03353333 7.544172e-01 1.447548e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000163608 E001 125.3804294 0.0082689898 9.864334e-05 0.01343313 3 113002444 113004565 2122 - 1.983 2.197 0.716
ENSG00000163608 E002 26.0290539 0.0188465935 1.048559e-03 0.05578159 3 113004566 113004916 351 - 1.239 1.559 1.108
ENSG00000163608 E003 10.3704769 0.0330234833 4.186679e-02 0.32001955 3 113004917 113004953 37 - 0.897 1.170 1.001
ENSG00000163608 E004 20.4957010 0.0016160928 4.753394e-02 0.33726403 3 113004954 113004963 10 - 1.256 1.412 0.543
ENSG00000163608 E005 75.4146569 0.0021123579 6.036869e-01 0.87722018 3 113004964 113005175 212 - 1.875 1.904 0.097
ENSG00000163608 E006 45.0846444 0.0048744944 8.448006e-01 0.96152684 3 113005176 113005242 67 - 1.659 1.678 0.064
ENSG00000163608 E007 32.3489188 0.0053976565 8.045075e-02 0.41849124 3 113005243 113005263 21 - 1.587 1.470 -0.399
ENSG00000163608 E008 63.0288817 0.0127682733 2.526470e-01 0.65853385 3 113005264 113005321 58 - 1.844 1.774 -0.235
ENSG00000163608 E009 84.8691061 0.0004461689 9.252186e-02 0.44306661 3 113005322 113005480 159 - 1.969 1.915 -0.181
ENSG00000163608 E010 178.7040738 0.0019788922 5.555500e-01 0.85626152 3 113005481 113005943 463 - 2.246 2.277 0.103
ENSG00000163608 E011 52.0106339 0.0018968680 9.694159e-01 0.99287678 3 113005944 113006004 61 - 1.730 1.740 0.034
ENSG00000163608 E012 94.6390784 0.0007234967 2.337811e-01 0.63867857 3 113008171 113008430 260 - 2.009 1.974 -0.116
ENSG00000163608 E013 8.8187350 0.0145336463 1.558376e-03 0.06956814 3 113008431 113008800 370 - 0.761 1.149 1.457
ENSG00000163608 E014 2.2903615 0.1196106684 3.355723e-01 0.72857807 3 113009498 113009584 87 - 0.394 0.634 1.162
ENSG00000163608 E015 2.3186580 0.0332596965 3.264796e-02 0.28974188 3 113010504 113010642 139 - 0.280 0.670 2.024
ENSG00000163608 E016 34.9722528 0.0065376933 5.584110e-01 0.85742104 3 113010643 113010657 15 - 1.585 1.554 -0.107
ENSG00000163608 E017 40.3763446 0.0013710142 2.327441e-01 0.63778398 3 113010658 113010704 47 - 1.657 1.601 -0.192
ENSG00000163608 E018 28.6187570 0.0009387777 5.995962e-02 0.37146137 3 113011045 113011055 11 - 1.534 1.423 -0.380
ENSG00000163608 E019 37.0974234 0.0012127401 6.003012e-02 0.37167986 3 113011056 113011092 37 - 1.632 1.534 -0.334
ENSG00000163608 E020 42.4877008 0.0138599617 7.243470e-02 0.40105783 3 113011093 113011165 73 - 1.695 1.583 -0.383
ENSG00000163608 E021 38.1918488 0.0170154719 4.152071e-01 0.78364845 3 113011166 113011261 96 - 1.619 1.575 -0.150
ENSG00000163608 E022 32.7925627 0.0099383301 2.760750e-01 0.67976013 3 113011262 113011379 118 - 1.564 1.497 -0.228
ENSG00000163608 E023 18.9076722 0.0015276726 3.087056e-01 0.70701008 3 113011380 113011406 27 - 1.335 1.266 -0.243
ENSG00000163608 E024 3.7549738 0.0616907918 5.337897e-02 0.35387167 3 113011407 113011536 130 - 0.451 0.823 1.631
ENSG00000163608 E025 2.4237845 0.0087252862 3.547795e-01 0.74310692 3 113012539 113012576 38 - 0.447 0.604 0.748
ENSG00000163608 E026 6.9187112 0.0265503862 3.695461e-03 0.10921013 3 113012577 113012733 157 - 0.634 1.067 1.692
ENSG00000163608 E027 28.9354744 0.0014023489 9.638334e-01 0.99176042 3 113012734 113012792 59 - 1.473 1.480 0.022
ENSG00000163608 E028 21.1495746 0.0013853227 9.020819e-01 0.97680948 3 113012793 113012811 19 - 1.341 1.358 0.059
ENSG00000163608 E029 6.5364179 0.0038130803 2.281953e-02 0.24933444 3 113012812 113013271 460 - 0.715 1.002 1.111
ENSG00000163608 E030 15.9905785 0.0020033671 8.646683e-01 0.96699132 3 113013272 113013274 3 - 1.219 1.242 0.079
ENSG00000163608 E031 25.5787630 0.0025460794 5.182788e-01 0.83924555 3 113013275 113013330 56 - 1.442 1.406 -0.122
ENSG00000163608 E032 25.2035245 0.0013752852 9.922886e-02 0.45584649 3 113013331 113013361 31 - 1.469 1.365 -0.360
ENSG00000163608 E033 26.4415863 0.0038321006 8.879872e-02 0.43595374 3 113013362 113013403 42 - 1.494 1.383 -0.383
ENSG00000163608 E034 2.0425269 0.2528656833 7.784141e-01 0.94190184 3 113013949 113013952 4 - 0.506 0.430 -0.380
ENSG00000163608 E035 33.3253699 0.0036882752 2.579768e-01 0.66376217 3 113013953 113014032 80 - 1.567 1.503 -0.217
ENSG00000163608 E036 27.4628548 0.0017589187 4.645229e-01 0.81089285 3 113017448 113017602 155 - 1.481 1.440 -0.142
ENSG00000163608 E037 0.6618996 0.0200493618 2.775548e-01   3 113019066 113019160 95 - 0.114 0.302 1.742
ENSG00000163608 E038 28.5517789 0.0011149820 4.208610e-02 0.32063102 3 113019542 113019861 320 - 1.534 1.412 -0.418