ENSG00000162062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361837 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding protein_coding 50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 6.268196 5.148383 14.244292 0.52952731 2.5955259 1.46640574 0.10215833 0.10243333 0.19536667 0.09293333 7.364943e-07 2.473295e-35 FALSE  
ENST00000562253 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding retained_intron 50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 2.858722 5.005692 3.649650 0.48285529 0.3086343 -0.45474308 0.06593750 0.09983333 0.05373333 -0.04610000 1.353209e-01 2.473295e-35 FALSE  
ENST00000563531 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding protein_coding 50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 2.937559 3.877898 3.621355 2.00154273 1.8109616 -0.09848254 0.05857083 0.07940000 0.05936667 -0.02003333 9.881360e-01 2.473295e-35 FALSE  
ENST00000566580 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding retained_intron 50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 4.084617 6.592315 4.062710 0.79203316 1.5316200 -0.69698287 0.09778333 0.13380000 0.06530000 -0.06850000 3.174319e-01 2.473295e-35    
ENST00000567489 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding protein_coding 50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 15.424773 11.183023 23.600729 1.58341433 4.4896121 1.07684291 0.30504167 0.22076667 0.32313333 0.10236667 5.788468e-02 2.473295e-35 FALSE  
ENST00000569496 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding protein_coding 50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 4.232359 4.686471 6.313191 2.05184974 3.1442957 0.42907553 0.08443750 0.09153333 0.07863333 -0.01290000 9.276722e-01 2.473295e-35 FALSE  
ENST00000569994 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding retained_intron 50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 4.930588 4.919558 7.038150 0.06484245 1.3883375 0.51578629 0.09519167 0.10000000 0.09750000 -0.00250000 9.864835e-01 2.473295e-35 FALSE  
MSTRG.11864.2 ENSG00000162062 HEK293_DMSO_6hA HEK293_OSMI2_6hA TEDC2 protein_coding   50.16519 50.15108 72.23717 4.579871 11.36641 0.5263728 2.112896 3.648247 0.000000 0.60553394 0.0000000 -8.51500884 0.05454583 0.07176667 0.00000000 -0.07176667 2.473295e-35 2.473295e-35 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000162062 E001 1.532000 0.0112677917 0.5903108096   16 2460086 2460093 8 + 0.368 0.460 0.497
ENSG00000162062 E002 3.181581 0.0315106032 0.5848959921 0.86899537 16 2460094 2460101 8 + 0.592 0.678 0.372
ENSG00000162062 E003 5.043326 0.1619876582 0.7508704844 0.93280377 16 2460102 2460108 7 + 0.763 0.821 0.230
ENSG00000162062 E004 13.255200 0.0629807004 0.9838922934 0.99610746 16 2460109 2460117 9 + 1.162 1.151 -0.040
ENSG00000162062 E005 42.418828 0.0007073262 0.3977657115 0.77180217 16 2460118 2460133 16 + 1.618 1.664 0.157
ENSG00000162062 E006 74.971227 0.0008334034 0.8693844985 0.96794348 16 2460134 2460144 11 + 1.876 1.885 0.031
ENSG00000162062 E007 90.343775 0.0022422641 0.5382488749 0.84898422 16 2460145 2460156 12 + 1.970 1.949 -0.072
ENSG00000162062 E008 107.894346 0.0016575948 0.4357644739 0.79486559 16 2460157 2460170 14 + 2.048 2.023 -0.083
ENSG00000162062 E009 31.442760 0.0033030509 0.0597954376 0.37111019 16 2460171 2460282 112 + 1.568 1.444 -0.428
ENSG00000162062 E010 171.080797 0.0002845975 0.8426301713 0.96093996 16 2460283 2460381 99 + 2.241 2.236 -0.015
ENSG00000162062 E011 63.685466 0.0010889050 0.9116573048 0.97891004 16 2460382 2460475 94 + 1.812 1.818 0.022
ENSG00000162062 E012 80.565077 0.0003522924 0.5923040538 0.87235892 16 2460476 2460622 147 + 1.924 1.903 -0.068
ENSG00000162062 E013 306.677018 0.0001710004 0.9422347271 0.98644129 16 2460623 2460693 71 + 2.486 2.489 0.011
ENSG00000162062 E014 26.961352 0.0010385445 0.0026634641 0.09264474 16 2460694 2460815 122 + 1.349 1.547 0.684
ENSG00000162062 E015 468.299667 0.0002049662 0.5833472497 0.86826251 16 2460816 2460936 121 + 2.673 2.667 -0.021
ENSG00000162062 E016 694.272925 0.0001073190 0.4341451126 0.79397657 16 2460937 2461224 288 + 2.846 2.838 -0.027
ENSG00000162062 E017 55.697562 0.0329390723 0.0002383055 0.02274377 16 2461225 2461449 225 + 1.539 1.920 1.288
ENSG00000162062 E018 57.477793 0.1089631821 0.0204743925 0.23821016 16 2461547 2461746 200 + 1.569 1.925 1.202
ENSG00000162062 E019 298.031669 0.0049538812 0.3745070246 0.75618101 16 2461747 2461800 54 + 2.483 2.465 -0.061
ENSG00000162062 E020 420.681964 0.0010392981 0.7781619172 0.94182753 16 2462149 2462239 91 + 2.624 2.625 0.006
ENSG00000162062 E021 423.870002 0.0011062101 0.1167248361 0.48764291 16 2462415 2462526 112 + 2.640 2.612 -0.096
ENSG00000162062 E022 326.560166 0.0001450133 0.0139752695 0.20263041 16 2462631 2462732 102 + 2.536 2.489 -0.155
ENSG00000162062 E023 288.214483 0.0023092370 0.5391257553 0.84942229 16 2464039 2464153 115 + 2.467 2.455 -0.040
ENSG00000162062 E024 263.142747 0.0032324329 0.5377154942 0.84873360 16 2464154 2464229 76 + 2.427 2.414 -0.042
ENSG00000162062 E025 273.061349 0.0013747229 0.0011557489 0.05880196 16 2464230 2464521 292 + 2.394 2.486 0.307
ENSG00000162062 E026 589.206769 0.0001687161 0.4513607257 0.80431623 16 2464522 2465320 799 + 2.765 2.778 0.045