ENSG00000161860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293695 ENSG00000161860 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYCE2 protein_coding protein_coding 1.229565 0.9975013 1.088962 0.13053 0.2992503 0.1253599 0.86178725 0.47868657 0.69187201 0.077397582 0.16820882 0.522298513 0.71842917 0.47633333 0.6677333 0.19140000 0.66848383 0.00109352 FALSE TRUE
ENST00000591229 ENSG00000161860 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYCE2 protein_coding processed_transcript 1.229565 0.9975013 1.088962 0.13053 0.2992503 0.1253599 0.03556767 0.28454136 0.00000000 0.060024050 0.00000000 -4.880398330 0.03564167 0.28513333 0.0000000 -0.28513333 0.00109352 0.00109352   FALSE
ENST00000592819 ENSG00000161860 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYCE2 protein_coding protein_coding 1.229565 0.9975013 1.088962 0.13053 0.2992503 0.1253599 0.04336014 0.00000000 0.21074122 0.000000000 0.21074122 4.464284168 0.02456667 0.00000000 0.1291000 0.12910000 0.74957775 0.00109352   FALSE
MSTRG.16529.3 ENSG00000161860 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYCE2 protein_coding   1.229565 0.9975013 1.088962 0.13053 0.2992503 0.1253599 0.09589590 0.08733175 0.04538235 0.030485247 0.04538235 -0.813484040 0.07815417 0.08933333 0.0756000 -0.01373333 0.75080590 0.00109352 FALSE TRUE
MSTRG.16529.5 ENSG00000161860 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYCE2 protein_coding   1.229565 0.9975013 1.088962 0.13053 0.2992503 0.1253599 0.11641497 0.11694314 0.11610150 0.007973449 0.02913343 -0.009597079 0.10170833 0.12173333 0.1123333 -0.00940000 0.96701166 0.00109352   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000161860 E001 0.0000000       19 12898786 12898984 199 -      
ENSG00000161860 E002 0.0000000       19 12898985 12899081 97 -      
ENSG00000161860 E003 8.4263824 0.003683416 0.054860057 0.35803258 19 12899082 12899385 304 - 1.058 0.867 -0.712
ENSG00000161860 E004 1.0416272 0.024865244 0.979186290   19 12899958 12900003 46 - 0.291 0.291 0.003
ENSG00000161860 E005 8.3271386 0.003179430 0.161979134 0.55674070 19 12900004 12900117 114 - 0.882 1.036 0.574
ENSG00000161860 E006 3.6446344 0.007930631 0.002174527 0.08312573 19 12900118 12900120 3 - 0.355 0.828 2.183
ENSG00000161860 E007 0.3262289 0.027442404 0.208633251   19 12900121 12900459 339 - 0.000 0.214 10.126
ENSG00000161860 E008 5.3193269 0.045336986 0.054682580 0.35753113 19 12900460 12900507 48 - 0.615 0.922 1.235
ENSG00000161860 E009 9.8722997 0.003103718 0.401104316 0.77410006 19 12900508 12900648 141 - 1.080 1.010 -0.257
ENSG00000161860 E010 1.8133319 0.011007843 0.382235876 0.76164523 19 12903402 12904491 1090 - 0.355 0.509 0.817
ENSG00000161860 E011 6.0770785 0.006043592 0.047892111 0.33842947 19 12904492 12904516 25 - 0.964 0.737 -0.880
ENSG00000161860 E012 9.1156896 0.004425172 0.035971950 0.30057888 19 12904517 12904666 150 - 1.103 0.903 -0.738
ENSG00000161860 E013 2.3597643 0.015543757 0.621824475 0.88485210 19 12904667 12904748 82 - 0.463 0.550 0.421
ENSG00000161860 E014 1.6319735 0.073903855 0.560427332   19 12904749 12904830 82 - 0.354 0.465 0.607
ENSG00000161860 E015 0.8056957 0.188352685 0.225778128   19 12906105 12906203 99 - 0.117 0.358 2.044
ENSG00000161860 E016 7.1113521 0.003883337 0.839346392 0.96001692 19 12918222 12918337 116 - 0.917 0.903 -0.053
ENSG00000161860 E017 0.5281116 0.023621696 0.581820405   19 12919053 12919242 190 - 0.119 0.214 1.011
ENSG00000161860 E018 2.4267378 0.009495064 0.988021849 0.99707769 19 12919243 12919299 57 - 0.547 0.550 0.014