ENSG00000161179

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292778 ENSG00000161179 HEK293_DMSO_6hA HEK293_OSMI2_6hA YDJC protein_coding protein_coding 109.2717 73.80676 159.5223 11.41323 38.61863 1.111828 17.507170 11.240826 28.857703 1.787879 8.589324 1.3594254 0.15981250 0.1521333 0.17396667 0.021833333 0.723728055 0.003311096 FALSE  
ENST00000415762 ENSG00000161179 HEK293_DMSO_6hA HEK293_OSMI2_6hA YDJC protein_coding nonsense_mediated_decay 109.2717 73.80676 159.5223 11.41323 38.61863 1.111828 30.349368 15.006753 45.651083 2.825060 12.717632 1.6043922 0.26142083 0.2011000 0.27826667 0.077166667 0.121119180 0.003311096 FALSE  
ENST00000464015 ENSG00000161179 HEK293_DMSO_6hA HEK293_OSMI2_6hA YDJC protein_coding retained_intron 109.2717 73.80676 159.5223 11.41323 38.61863 1.111828 16.540098 16.791308 24.722644 2.185991 2.643092 0.5578429 0.17137083 0.2296667 0.17160000 -0.058066667 0.448651998 0.003311096 FALSE  
ENST00000468686 ENSG00000161179 HEK293_DMSO_6hA HEK293_OSMI2_6hA YDJC protein_coding retained_intron 109.2717 73.80676 159.5223 11.41323 38.61863 1.111828 26.054620 20.476413 32.693301 2.826101 7.687121 0.6747689 0.24806667 0.2797000 0.20640000 -0.073300000 0.003311096 0.003311096 FALSE  
ENST00000473985 ENSG00000161179 HEK293_DMSO_6hA HEK293_OSMI2_6hA YDJC protein_coding retained_intron 109.2717 73.80676 159.5223 11.41323 38.61863 1.111828 6.366334 3.764315 9.569298 0.832151 2.763634 1.3437052 0.06437917 0.0505000 0.05793333 0.007433333 0.753661658 0.003311096 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000161179 E001 8.25726 0.1329918923 3.925830e-01 0.768624332 22 21627925 21628088 164 - 0.987 0.879 -0.409
ENSG00000161179 E002 31.71039 0.0008936496 4.069887e-01 0.778153404 22 21628089 21628101 13 - 1.534 1.473 -0.208
ENSG00000161179 E003 84.21593 0.0010154454 2.865315e-01 0.688857139 22 21628102 21628106 5 - 1.946 1.892 -0.179
ENSG00000161179 E004 161.20615 0.0011524967 2.722859e-01 0.676191071 22 21628107 21628113 7 - 2.186 2.218 0.110
ENSG00000161179 E005 337.41582 0.0005838297 3.821972e-01 0.761621243 22 21628114 21628121 8 - 2.513 2.528 0.053
ENSG00000161179 E006 815.97536 0.0002380977 7.902245e-05 0.011861170 22 21628122 21628166 45 - 2.882 2.934 0.174
ENSG00000161179 E007 1226.31197 0.0002473430 3.329632e-04 0.028323923 22 21628167 21628255 89 - 3.063 3.104 0.137
ENSG00000161179 E008 1747.79641 0.0011008800 6.353146e-03 0.140984675 22 21628256 21628360 105 - 3.209 3.261 0.173
ENSG00000161179 E009 3414.23662 0.0002461493 2.809798e-01 0.684044957 22 21628361 21628787 427 - 3.518 3.529 0.038
ENSG00000161179 E010 787.09566 0.0031710497 2.160919e-04 0.021403692 22 21629010 21629176 167 - 2.916 2.821 -0.318
ENSG00000161179 E011 390.63723 0.0006119323 4.082106e-05 0.007739608 22 21629177 21629187 11 - 2.617 2.524 -0.310
ENSG00000161179 E012 230.11469 0.0147899715 2.106097e-01 0.614944011 22 21629188 21629307 120 - 2.308 2.411 0.344
ENSG00000161179 E013 1291.43007 0.0003177359 2.130895e-04 0.021248248 22 21629308 21629407 100 - 3.116 3.072 -0.148
ENSG00000161179 E014 608.78929 0.0101054476 3.224150e-02 0.288273819 22 21629408 21629542 135 - 2.718 2.846 0.427
ENSG00000161179 E015 871.37846 0.0004525186 4.863072e-01 0.822629857 22 21629543 21629601 59 - 2.923 2.938 0.048
ENSG00000161179 E016 1486.40521 0.0003432362 4.186751e-04 0.032475085 22 21629602 21629755 154 - 3.176 3.135 -0.137
ENSG00000161179 E017 524.58339 0.0018813025 1.350591e-03 0.064300619 22 21629756 21629761 6 - 2.738 2.656 -0.273
ENSG00000161179 E018 239.51278 0.0022989003 3.043042e-01 0.703350828 22 21629762 21629850 89 - 2.357 2.392 0.117
ENSG00000161179 E019 936.87892 0.0024423482 9.767448e-02 0.453059226 22 21629851 21630773 923 - 2.971 2.939 -0.107