ENSG00000160932

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292494 ENSG00000160932 HEK293_DMSO_6hA HEK293_OSMI2_6hA LY6E protein_coding protein_coding 229.3734 221.5357 349.5567 29.92943 56.31317 0.6579636 102.21472 104.30727 139.08938 14.81702 19.58774 0.4151380 0.4547292 0.4697667 0.4008000 -0.06896667 0.006189175 0.006189175 FALSE FALSE
ENST00000429120 ENSG00000160932 HEK293_DMSO_6hA HEK293_OSMI2_6hA LY6E protein_coding protein_coding 229.3734 221.5357 349.5567 29.92943 56.31317 0.6579636 75.15652 70.33791 120.36635 11.35513 22.79867 0.7749725 0.3224500 0.3147667 0.3416667 0.02690000 0.652593498 0.006189175 FALSE TRUE
MSTRG.32180.2 ENSG00000160932 HEK293_DMSO_6hA HEK293_OSMI2_6hA LY6E protein_coding   229.3734 221.5357 349.5567 29.92943 56.31317 0.6579636 38.55377 34.65793 70.73961 2.94854 12.17825 1.0291205 0.1645750 0.1603333 0.2014000 0.04106667 0.336601560 0.006189175 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000160932 E001 0.00000       8 143017982 143018247 266 +      
ENSG00000160932 E002 41.52643 3.646582e-03 7.859038e-03 0.1553605834 8 143018467 143018482 16 + 1.695 1.531 -0.558
ENSG00000160932 E003 381.85693 9.880228e-04 8.035979e-06 0.0026213270 8 143018483 143018516 34 + 2.623 2.520 -0.344
ENSG00000160932 E004 533.34390 1.351806e-03 7.205744e-04 0.0451268587 8 143018517 143018527 11 + 2.756 2.681 -0.249
ENSG00000160932 E005 536.89165 1.542890e-03 1.326199e-03 0.0635704812 8 143018528 143018528 1 + 2.758 2.685 -0.244
ENSG00000160932 E006 655.29627 9.231262e-04 6.898208e-04 0.0441008962 8 143018529 143018541 13 + 2.841 2.777 -0.211
ENSG00000160932 E007 658.74713 8.405959e-04 4.475100e-04 0.0336921520 8 143018542 143018543 2 + 2.843 2.779 -0.213
ENSG00000160932 E008 725.35521 1.100504e-03 3.864525e-03 0.1111512739 8 143018544 143018545 2 + 2.881 2.827 -0.182
ENSG00000160932 E009 903.68078 4.790091e-04 1.105372e-02 0.1819510310 8 143018546 143018551 6 + 2.970 2.934 -0.121
ENSG00000160932 E010 896.30868 4.341253e-04 1.435334e-02 0.2047297438 8 143018552 143018552 1 + 2.966 2.931 -0.114
ENSG00000160932 E011 946.71250 6.184878e-04 2.226969e-02 0.2469107820 8 143018553 143018556 4 + 2.988 2.955 -0.110
ENSG00000160932 E012 1107.83053 1.799493e-04 1.372336e-02 0.2013310490 8 143018557 143018586 30 + 3.055 3.027 -0.092
ENSG00000160932 E013 14.96173 1.881189e-03 6.595369e-01 0.9004127647 8 143018833 143019119 287 + 1.225 1.186 -0.140
ENSG00000160932 E014 29.89644 1.829396e-02 2.042077e-01 0.6081303760 8 143020262 143020377 116 + 1.520 1.421 -0.340
ENSG00000160932 E015 716.21832 1.083593e-03 7.386917e-01 0.9285774457 8 143020883 143020887 5 + 2.853 2.851 -0.006
ENSG00000160932 E016 1153.04206 6.178753e-05 9.840596e-01 0.9961485783 8 143020888 143020916 29 + 3.060 3.061 0.005
ENSG00000160932 E017 1847.61481 9.942434e-05 2.785583e-01 0.6819069273 8 143020917 143020991 75 + 3.257 3.271 0.045
ENSG00000160932 E018 1057.68797 1.010875e-03 3.929885e-01 0.7688440862 8 143021314 143021317 4 + 3.007 3.037 0.098
ENSG00000160932 E019 1417.57863 1.294618e-03 7.932402e-01 0.9459313635 8 143021318 143021348 31 + 3.138 3.159 0.071
ENSG00000160932 E020 2249.00775 3.395052e-04 7.261512e-01 0.9243563239 8 143021349 143021433 85 + 3.342 3.356 0.047
ENSG00000160932 E021 15.39388 5.095154e-02 9.137438e-01 0.9793808987 8 143021434 143021548 115 + 1.199 1.201 0.005
ENSG00000160932 E022 24.87815 1.110235e-03 1.040639e-01 0.4649301428 8 143021549 143021565 17 + 1.454 1.341 -0.392
ENSG00000160932 E023 5774.85573 6.760989e-04 4.661937e-03 0.1226424800 8 143021566 143022120 555 + 3.737 3.783 0.151
ENSG00000160932 E024 1892.96441 6.685762e-04 1.098262e-04 0.0141952644 8 143022121 143022200 80 + 3.242 3.312 0.233
ENSG00000160932 E025 1345.63929 7.685265e-05 1.539997e-06 0.0007931068 8 143022201 143022411 211 + 3.104 3.155 0.171
ENSG00000160932 E026 17.10360 1.161161e-02 2.871999e-01 0.6892039832 8 143022549 143023042 494 + 1.205 1.310 0.368
ENSG00000160932 E027 22.28647 1.181074e-03 1.404759e-03 0.0657202599 8 143023669 143023832 164 + 1.245 1.478 0.809