ENSG00000160789

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368299 ENSG00000160789 HEK293_DMSO_6hA HEK293_OSMI2_6hA LMNA protein_coding protein_coding 44.00611 43.47409 68.05333 5.481837 11.65271 0.64639 4.551172 4.971319 4.169053 1.5266082 0.9812344 -0.253351802 0.11157500 0.11633333 0.06026667 -0.05606667 0.3887576 0.043742 FALSE TRUE
ENST00000368300 ENSG00000160789 HEK293_DMSO_6hA HEK293_OSMI2_6hA LMNA protein_coding protein_coding 44.00611 43.47409 68.05333 5.481837 11.65271 0.64639 3.034632 2.996636 4.340240 0.4512442 1.0594899 0.532944955 0.06205833 0.06876667 0.06256667 -0.00620000 0.8246074 0.043742 FALSE TRUE
ENST00000448611 ENSG00000160789 HEK293_DMSO_6hA HEK293_OSMI2_6hA LMNA protein_coding protein_coding 44.00611 43.47409 68.05333 5.481837 11.65271 0.64639 4.728778 4.640610 4.653498 0.9196902 0.7625439 0.003992612 0.11709583 0.10520000 0.06920000 -0.03600000 0.2342393 0.043742 FALSE TRUE
ENST00000677389 ENSG00000160789 HEK293_DMSO_6hA HEK293_OSMI2_6hA LMNA protein_coding protein_coding 44.00611 43.47409 68.05333 5.481837 11.65271 0.64639 14.321541 12.926716 24.032004 2.5039813 5.1783170 0.894085700 0.29008750 0.29153333 0.34633333 0.05480000 0.5323560 0.043742 FALSE TRUE
ENST00000683032 ENSG00000160789 HEK293_DMSO_6hA HEK293_OSMI2_6hA LMNA protein_coding protein_coding 44.00611 43.47409 68.05333 5.481837 11.65271 0.64639 13.016320 11.754460 26.442946 1.8251155 4.8497512 1.168993284 0.28722500 0.27040000 0.38720000 0.11680000 0.0437420 0.043742 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000160789 E001 0.3435364 2.603732e-01 0.168424538   1 156082573 156082577 5 + 0.000 0.249 11.959
ENSG00000160789 E002 1.1492321 1.369538e-02 0.014199286   1 156082578 156082599 22 + 0.101 0.520 3.148
ENSG00000160789 E003 1.6831866 1.774698e-02 0.032181402 0.28808535 1 156082600 156082625 26 + 0.250 0.611 1.982
ENSG00000160789 E004 2.0456068 9.410376e-03 0.126815656 0.50545984 1 156082626 156082630 5 + 0.362 0.611 1.240
ENSG00000160789 E005 2.7499260 7.714481e-03 0.046149825 0.33322605 1 156082631 156082663 33 + 0.409 0.719 1.436
ENSG00000160789 E006 7.9171551 3.478128e-03 0.725308823 0.92406830 1 156082948 156083184 237 + 0.920 0.958 0.144
ENSG00000160789 E007 2.1640815 1.707649e-01 0.539213014 0.84950132 1 156083521 156083613 93 + 0.592 0.406 -0.911
ENSG00000160789 E008 4.9287359 9.076661e-02 0.440747989 0.79813190 1 156090471 156090582 112 + 0.683 0.833 0.605
ENSG00000160789 E009 5.6921637 5.597488e-02 0.030559764 0.28166349 1 156090999 156091097 99 + 0.622 0.978 1.418
ENSG00000160789 E010 9.2147819 3.546685e-03 0.456814720 0.80703039 1 156093340 156093708 369 + 0.982 1.057 0.276
ENSG00000160789 E011 3.9145582 1.137052e-02 0.539930120 0.84979226 1 156093709 156093778 70 + 0.666 0.750 0.349
ENSG00000160789 E012 1.6492810 1.743409e-02 0.225758587 0.63075045 1 156093779 156093811 33 + 0.310 0.520 1.149
ENSG00000160789 E013 0.0000000       1 156099034 156099046 13 +      
ENSG00000160789 E014 1.1968926 1.356630e-02 0.880306078   1 156104765 156104917 153 + 0.362 0.333 -0.174
ENSG00000160789 E015 0.7597844 1.726718e-02 0.047591701   1 156106658 156106697 40 + 0.363 0.000 -16.098
ENSG00000160789 E016 1.3624324 1.560037e-02 0.265080967   1 156106698 156106724 27 + 0.451 0.248 -1.249
ENSG00000160789 E017 2.1027701 1.061073e-02 0.742940478 0.93030509 1 156106725 156106770 46 + 0.524 0.466 -0.286
ENSG00000160789 E018 2.8805515 1.635861e-02 0.851616104 0.96329412 1 156106771 156106823 53 + 0.587 0.610 0.103
ENSG00000160789 E019 2.0389280 1.637001e-01 0.696585535 0.91381934 1 156109513 156109746 234 + 0.451 0.519 0.333
ENSG00000160789 E020 0.8587799 1.726718e-02 0.073970492   1 156112119 156112121 3 + 0.101 0.405 2.559
ENSG00000160789 E021 0.8587799 1.726718e-02 0.073970492   1 156112122 156112122 1 + 0.101 0.405 2.559
ENSG00000160789 E022 0.9712965 1.514103e-02 0.197924559   1 156112123 156112130 8 + 0.182 0.405 1.561
ENSG00000160789 E023 1.1040102 6.778233e-02 0.114202664   1 156114251 156114284 34 + 0.182 0.465 1.880
ENSG00000160789 E024 5.1239254 4.399435e-03 0.660681512 0.90081777 1 156114670 156114710 41 + 0.811 0.750 -0.246
ENSG00000160789 E025 4.4132003 5.102655e-03 0.630018771 0.88809089 1 156114711 156114712 2 + 0.756 0.686 -0.287
ENSG00000160789 E026 14.5041736 1.814819e-03 0.524612434 0.84239462 1 156114713 156114721 9 + 1.208 1.149 -0.210
ENSG00000160789 E027 216.8418934 1.487560e-03 0.006978761 0.14728012 1 156114722 156114791 70 + 2.366 2.286 -0.267
ENSG00000160789 E028 316.2262348 2.481532e-03 0.012876695 0.19545518 1 156114792 156114911 120 + 2.526 2.456 -0.233
ENSG00000160789 E029 241.7583754 1.353563e-03 0.001617824 0.07120530 1 156114912 156114963 52 + 2.418 2.330 -0.294
ENSG00000160789 E030 217.5684130 2.536538e-03 0.109189008 0.47421311 1 156114964 156115001 38 + 2.357 2.307 -0.166
ENSG00000160789 E031 281.7486298 2.963660e-03 0.247087572 0.65250939 1 156115002 156115066 65 + 2.459 2.430 -0.099
ENSG00000160789 E032 248.9755046 1.847165e-04 0.841649262 0.96080301 1 156115067 156115090 24 + 2.397 2.390 -0.023
ENSG00000160789 E033 552.3339731 1.919587e-04 0.535092577 0.84742680 1 156115091 156115274 184 + 2.743 2.732 -0.035
ENSG00000160789 E034 0.1767706 5.789840e-02 0.689478968   1 156123142 156123395 254 + 0.101 0.000 -13.160
ENSG00000160789 E035 0.1125166 3.216160e-02 0.692310404   1 156126160 156126173 14 + 0.100 0.000 -13.462
ENSG00000160789 E036 0.1125166 3.216160e-02 0.692310404   1 156126174 156126174 1 + 0.100 0.000 -13.462
ENSG00000160789 E037 0.8405492 1.954561e-02 0.743150673   1 156126175 156126188 14 + 0.310 0.248 -0.435
ENSG00000160789 E038 5.8738784 4.378862e-03 0.418069451 0.78524481 1 156126189 156126223 35 + 0.776 0.878 0.399
ENSG00000160789 E039 0.1795728 3.248526e-02 0.338555687   1 156126545 156126554 10 + 0.000 0.141 13.238
ENSG00000160789 E040 0.1795728 3.248526e-02 0.338555687   1 156126555 156126651 97 + 0.000 0.141 13.238
ENSG00000160789 E041 0.3591457 2.164119e-01 0.159384919   1 156126736 156126915 180 + 0.000 0.250 13.452
ENSG00000160789 E042 0.0000000       1 156126916 156126949 34 +      
ENSG00000160789 E043 0.0000000       1 156129827 156129908 82 +      
ENSG00000160789 E044 430.4074295 1.059167e-04 0.740369734 0.92920090 1 156130617 156130674 58 + 2.629 2.633 0.011
ENSG00000160789 E045 474.4075220 9.765694e-05 0.141098941 0.52682088 1 156130675 156130773 99 + 2.665 2.686 0.072
ENSG00000160789 E046 637.1566855 8.046949e-05 0.754846943 0.93413190 1 156134403 156134523 121 + 2.802 2.804 0.006
ENSG00000160789 E047 318.6130728 1.900771e-04 0.988734621 0.99722410 1 156134524 156134528 5 + 2.501 2.499 -0.007
ENSG00000160789 E048 690.4919167 8.419056e-05 0.301075308 0.70074116 1 156134805 156134975 171 + 2.844 2.827 -0.055
ENSG00000160789 E049 0.8073330 1.804457e-02 0.379685448   1 156135113 156135186 74 + 0.182 0.333 1.146
ENSG00000160789 E050 546.8126691 7.533190e-04 0.783887340 0.94333844 1 156135187 156135312 126 + 2.739 2.733 -0.020
ENSG00000160789 E051 0.8433514 2.451290e-02 0.620362030   1 156135313 156135408 96 + 0.250 0.333 0.570
ENSG00000160789 E052 1.3991967 1.300080e-01 0.022303194   1 156135733 156135860 128 + 0.102 0.570 3.367
ENSG00000160789 E053 4.4651856 1.693443e-02 0.065156096 0.38466017 1 156135861 156135900 40 + 0.589 0.855 1.094
ENSG00000160789 E054 806.4763992 5.197920e-04 0.774816266 0.94078528 1 156135901 156136121 221 + 2.902 2.907 0.019
ENSG00000160789 E055 2.9700904 2.140827e-02 0.547838854 0.85316999 1 156136122 156136213 92 + 0.619 0.520 -0.450
ENSG00000160789 E056 452.8546433 1.165948e-04 0.385679978 0.76429587 1 156136214 156136292 79 + 2.649 2.661 0.040
ENSG00000160789 E057 740.8151039 8.854522e-05 0.899449985 0.97597641 1 156136293 156136436 144 + 2.870 2.866 -0.014
ENSG00000160789 E058 1.5490741 2.637225e-01 0.306218483   1 156136437 156136549 113 + 0.343 0.517 0.928
ENSG00000160789 E059 2.9782919 1.909336e-01 0.076335394 0.40998028 1 156136550 156136920 371 + 0.369 0.776 1.891
ENSG00000160789 E060 719.6277964 1.507294e-04 0.081961191 0.42184243 1 156136921 156137028 108 + 2.844 2.867 0.076
ENSG00000160789 E061 7.2810354 3.286838e-03 0.539275216 0.84950132 1 156137029 156137112 84 + 0.891 0.958 0.254
ENSG00000160789 E062 647.8844872 1.815608e-03 0.320721433 0.71722575 1 156137113 156137203 91 + 2.792 2.826 0.114
ENSG00000160789 E063 395.3734990 1.375833e-04 0.146217659 0.53386434 1 156137204 156137232 29 + 2.584 2.608 0.080
ENSG00000160789 E064 3.7489713 6.439061e-02 0.566571746 0.86067471 1 156137233 156137461 229 + 0.696 0.613 -0.354
ENSG00000160789 E065 2.6288623 4.390447e-02 0.667312078 0.90311683 1 156137462 156137653 192 + 0.551 0.611 0.273
ENSG00000160789 E066 393.5097978 1.367558e-04 0.460789806 0.80894387 1 156137654 156137700 47 + 2.589 2.600 0.037
ENSG00000160789 E067 322.5510531 1.230987e-04 0.613160899 0.88140982 1 156137701 156137743 43 + 2.513 2.500 -0.043
ENSG00000160789 E068 166.7619804 2.048274e-04 0.618371800 0.88325177 1 156137744 156138487 744 + 2.216 2.228 0.038
ENSG00000160789 E069 127.2941110 1.367272e-03 0.210614057 0.61494576 1 156138488 156138607 120 + 2.120 2.076 -0.148
ENSG00000160789 E070 134.4946215 3.114142e-04 0.709259698 0.91841679 1 156138608 156138757 150 + 2.133 2.119 -0.047
ENSG00000160789 E071 19.1800891 4.489730e-02 0.001642011 0.07174479 1 156138758 156139079 322 + 1.087 1.481 1.382
ENSG00000160789 E072 55.7105676 5.696433e-04 0.984450834 0.99621886 1 156139080 156139102 23 + 1.751 1.749 -0.007
ENSG00000160789 E073 223.0435385 1.748041e-04 0.402588991 0.77521473 1 156139103 156139664 562 + 2.339 2.357 0.058
ENSG00000160789 E074 34.7656387 1.836337e-03 0.386460105 0.76473235 1 156139665 156139769 105 + 1.535 1.584 0.167
ENSG00000160789 E075 47.9088847 4.201270e-03 0.043301324 0.32449808 1 156139770 156140081 312 + 1.635 1.753 0.401