ENSG00000160767

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350210 ENSG00000160767 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM189B protein_coding protein_coding 72.8151 58.5885 108.6092 6.27543 19.83806 0.890344 23.05249 17.128176 36.606495 2.967879 6.7892055 1.0952802 0.3109083 0.2876667 0.33720000 0.04953333 0.44967675 0.01572072 FALSE  
ENST00000361361 ENSG00000160767 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM189B protein_coding protein_coding 72.8151 58.5885 108.6092 6.27543 19.83806 0.890344 26.82608 21.654150 47.192107 2.478104 10.5114045 1.1235416 0.3766333 0.3693000 0.42616667 0.05686667 0.38945488 0.01572072 FALSE  
ENST00000368366 ENSG00000160767 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM189B protein_coding retained_intron 72.8151 58.5885 108.6092 6.27543 19.83806 0.890344 11.60809 9.340288 6.656691 1.013654 0.4786814 -0.4880399 0.1469042 0.1644000 0.06553333 -0.09886667 0.01572072 0.01572072 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000160767 E001 16.82845 1.687956e-03 0.333280737 0.72711928 1 155247205 155247216 12 - 1.218 1.292 0.259
ENSG00000160767 E002 500.78884 9.750776e-05 0.004061645 0.11403780 1 155247217 155247361 145 - 2.676 2.717 0.138
ENSG00000160767 E003 662.09745 8.346863e-05 0.269038712 0.67360063 1 155247362 155247426 65 - 2.810 2.820 0.035
ENSG00000160767 E004 513.08755 1.038431e-04 0.055017520 0.35843909 1 155247427 155247440 14 - 2.693 2.719 0.086
ENSG00000160767 E005 532.02027 1.096357e-04 0.019617026 0.23386459 1 155247441 155247447 7 - 2.706 2.738 0.108
ENSG00000160767 E006 539.08877 1.010617e-04 0.011632490 0.18648870 1 155247448 155247455 8 - 2.711 2.746 0.115
ENSG00000160767 E007 606.95080 8.150559e-05 0.011310527 0.18397147 1 155247456 155247473 18 - 2.764 2.796 0.107
ENSG00000160767 E008 576.53758 1.096950e-04 0.024570461 0.25686370 1 155247474 155247489 16 - 2.741 2.771 0.098
ENSG00000160767 E009 674.78114 8.455957e-04 0.242315569 0.64733949 1 155247490 155247526 37 - 2.811 2.834 0.078
ENSG00000160767 E010 1912.36860 5.860395e-04 0.624100355 0.88569659 1 155247527 155247955 429 - 3.276 3.269 -0.023
ENSG00000160767 E011 472.05701 1.753461e-03 0.080437453 0.41849124 1 155248050 155248073 24 - 2.686 2.636 -0.166
ENSG00000160767 E012 1208.74832 4.467279e-04 0.183406104 0.58363180 1 155248074 155248303 230 - 3.083 3.063 -0.067
ENSG00000160767 E013 625.73986 9.381030e-04 0.826220849 0.95590381 1 155248405 155248473 69 - 2.790 2.787 -0.012
ENSG00000160767 E014 771.86460 8.380859e-05 0.057273981 0.36460689 1 155250276 155250587 312 - 2.894 2.863 -0.101
ENSG00000160767 E015 522.44225 5.604960e-04 0.049788229 0.34377069 1 155250588 155250693 106 - 2.725 2.686 -0.129
ENSG00000160767 E016 610.56913 2.615448e-03 0.327875476 0.72293855 1 155250694 155250821 128 - 2.783 2.767 -0.055
ENSG00000160767 E017 23.53597 6.954897e-02 0.014452550 0.20534029 1 155250822 155250929 108 - 1.191 1.558 1.274
ENSG00000160767 E018 606.60773 9.197845e-05 0.895048744 0.97486317 1 155251095 155251164 70 - 2.779 2.772 -0.023
ENSG00000160767 E019 594.53651 1.123557e-04 0.192796586 0.59486988 1 155251502 155251601 100 - 2.762 2.777 0.050
ENSG00000160767 E020 15.98689 1.674049e-01 0.060460722 0.37264323 1 155251602 155251732 131 - 1.040 1.394 1.253
ENSG00000160767 E021 644.32161 9.445648e-05 0.620937455 0.88446864 1 155251733 155251905 173 - 2.803 2.805 0.007
ENSG00000160767 E022 36.41811 1.563915e-02 0.831640343 0.95739487 1 155251906 155251908 3 - 1.565 1.549 -0.055
ENSG00000160767 E023 16.43887 9.180503e-02 0.012623006 0.19384169 1 155251909 155252068 160 - 1.016 1.428 1.459
ENSG00000160767 E024 48.52658 1.308619e-01 0.005174707 0.12883775 1 155252749 155253624 876 - 1.432 1.906 1.609
ENSG00000160767 E025 600.06342 9.568378e-05 0.803861817 0.94953301 1 155253625 155253732 108 - 2.775 2.766 -0.029
ENSG00000160767 E026 384.11050 1.180845e-04 0.748589502 0.93219107 1 155253859 155253978 120 - 2.582 2.571 -0.038
ENSG00000160767 E027 378.15608 2.875573e-04 0.136269077 0.51974588 1 155254084 155254194 111 - 2.583 2.549 -0.111
ENSG00000160767 E028 253.04306 1.498894e-04 0.105741360 0.46791004 1 155254400 155254456 57 - 2.413 2.370 -0.142
ENSG00000160767 E029 17.13949 1.744812e-02 0.261793736 0.66709569 1 155254457 155254535 79 - 1.196 1.311 0.404
ENSG00000160767 E030 1479.53494 8.466412e-04 0.001640513 0.07174479 1 155254653 155255579 927 - 3.179 3.134 -0.150