ENSG00000160633

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292123 ENSG00000160633 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAFB protein_coding protein_coding 115.3791 80.72994 130.2504 4.943595 25.28906 0.6900442 11.177505 8.303532 10.38989 1.1816012 3.987974 0.3230342 0.09422500 0.10523333 0.07426667 -0.030966667 0.6909335225 0.0004095848 FALSE TRUE
ENST00000588852 ENSG00000160633 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAFB protein_coding protein_coding 115.3791 80.72994 130.2504 4.943595 25.28906 0.6900442 36.030366 18.185918 43.79940 1.7903308 11.244038 1.2676256 0.31035833 0.22440000 0.32760000 0.103200000 0.0737312528 0.0004095848 FALSE TRUE
ENST00000592224 ENSG00000160633 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAFB protein_coding protein_coding 115.3791 80.72994 130.2504 4.943595 25.28906 0.6900442 43.567129 29.518513 50.36536 1.2662457 12.312153 0.7706094 0.36911250 0.36820000 0.37783333 0.009633333 0.9518544389 0.0004095848 FALSE TRUE
MSTRG.16248.1 ENSG00000160633 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAFB protein_coding   115.3791 80.72994 130.2504 4.943595 25.28906 0.6900442 9.604282 2.064655 11.99194 0.6804966 3.441894 2.5323239 0.08226667 0.02476667 0.08896667 0.064200000 0.0004095848 0.0004095848 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000160633 E001 4.324718 1.087567e-02 0.3816744101 0.76134634 19 5623034 5623034 1 + 0.752 0.633 -0.501
ENSG00000160633 E002 10.331620 2.484283e-03 0.0476475841 0.33749624 19 5623035 5623082 48 + 1.128 0.925 -0.746
ENSG00000160633 E003 17.835780 7.307716e-03 0.0054513962 0.13186332 19 5623083 5623098 16 + 1.366 1.111 -0.898
ENSG00000160633 E004 20.039237 7.244796e-03 0.0026036474 0.09148596 19 5623099 5623100 2 + 1.416 1.151 -0.930
ENSG00000160633 E005 66.115409 4.716971e-04 0.0001446267 0.01683002 19 5623101 5623117 17 + 1.884 1.720 -0.554
ENSG00000160633 E006 78.200935 5.853055e-03 0.0142451233 0.20430545 19 5623118 5623120 3 + 1.941 1.814 -0.426
ENSG00000160633 E007 121.271527 5.824532e-03 0.0074170801 0.15173349 19 5623121 5623138 18 + 2.126 2.002 -0.416
ENSG00000160633 E008 663.190836 1.128364e-03 0.0450038932 0.32996740 19 5623139 5623394 256 + 2.827 2.798 -0.097
ENSG00000160633 E009 573.768252 3.183339e-04 0.6737349204 0.90542975 19 5626405 5626489 85 + 2.750 2.755 0.015
ENSG00000160633 E010 609.359494 9.217395e-05 0.3933416280 0.76901214 19 5641594 5641658 65 + 2.780 2.777 -0.011
ENSG00000160633 E011 730.540361 1.812540e-04 0.6523695529 0.89742988 19 5641740 5641850 111 + 2.850 2.867 0.056
ENSG00000160633 E012 606.887974 8.300111e-04 0.6961241406 0.91375430 19 5641851 5641946 96 + 2.776 2.779 0.008
ENSG00000160633 E013 497.767518 9.318045e-04 0.4337034189 0.79372724 19 5645337 5645399 63 + 2.696 2.688 -0.028
ENSG00000160633 E014 406.249059 7.083745e-04 0.9870157952 0.99679103 19 5648016 5648043 28 + 2.601 2.610 0.030
ENSG00000160633 E015 59.669747 1.754850e-01 0.0165465563 0.21794081 19 5648044 5648404 361 + 1.514 1.998 1.636
ENSG00000160633 E016 13.233743 7.480251e-02 0.0028229308 0.09544685 19 5648855 5648988 134 + 0.875 1.368 1.780
ENSG00000160633 E017 776.304145 7.999111e-04 0.0360512517 0.30080520 19 5648989 5649499 511 + 2.896 2.867 -0.097
ENSG00000160633 E018 35.925333 1.635506e-01 0.0247999470 0.25775151 19 5649684 5649925 242 + 1.322 1.768 1.529
ENSG00000160633 E019 451.210517 2.180655e-03 0.7437628519 0.93064867 19 5649926 5649975 50 + 2.636 2.662 0.087
ENSG00000160633 E020 593.276509 5.548271e-04 0.6968429860 0.91390072 19 5650978 5651072 95 + 2.759 2.778 0.063
ENSG00000160633 E021 955.323968 5.031773e-04 0.6492016324 0.89611346 19 5653115 5653264 150 + 2.965 2.986 0.069
ENSG00000160633 E022 913.282170 8.425134e-04 0.0389469622 0.31043324 19 5653338 5653420 83 + 2.932 2.984 0.175
ENSG00000160633 E023 1158.348006 7.809533e-05 0.3381309744 0.73054507 19 5654061 5654200 140 + 3.049 3.069 0.067
ENSG00000160633 E024 843.116197 4.194367e-04 0.6255249920 0.88625935 19 5654368 5654456 89 + 2.917 2.921 0.011
ENSG00000160633 E025 757.626918 9.039453e-05 0.4481480754 0.80264337 19 5657241 5657324 84 + 2.875 2.874 -0.004
ENSG00000160633 E026 505.846194 1.178757e-04 0.3558327733 0.74397929 19 5657325 5657347 23 + 2.702 2.696 -0.021
ENSG00000160633 E027 6.035227 4.077274e-03 0.0092745464 0.16761651 19 5661488 5661517 30 + 0.669 1.003 1.306
ENSG00000160633 E028 171.486773 6.979134e-04 0.7233951938 0.92331569 19 5661518 5661520 3 + 2.234 2.232 -0.007
ENSG00000160633 E029 1082.392182 2.229660e-03 0.1499939724 0.53937223 19 5661521 5661808 288 + 3.035 3.014 -0.069
ENSG00000160633 E030 639.097407 2.618343e-03 0.1252687272 0.50286392 19 5664022 5664128 107 + 2.810 2.780 -0.100
ENSG00000160633 E031 455.878039 4.088111e-04 0.1568414337 0.54937933 19 5664129 5664159 31 + 2.662 2.644 -0.060
ENSG00000160633 E032 542.038647 1.139600e-03 0.8149084473 0.95298370 19 5664397 5664439 43 + 2.727 2.731 0.013
ENSG00000160633 E033 53.989925 1.450648e-01 0.0583447325 0.36743425 19 5664440 5664725 286 + 1.555 1.906 1.187
ENSG00000160633 E034 315.831986 1.944725e-01 0.0550638976 0.35858662 19 5664726 5666655 1930 + 2.289 2.685 1.319
ENSG00000160633 E035 91.781584 1.599862e-01 0.0378528918 0.30666690 19 5666656 5667045 390 + 1.751 2.154 1.353
ENSG00000160633 E036 827.962935 6.587033e-04 0.2465233680 0.65197887 19 5667046 5667164 119 + 2.917 2.907 -0.034
ENSG00000160633 E037 31.032617 1.210737e-01 0.0286838971 0.27448535 19 5667165 5667346 182 + 1.293 1.690 1.366
ENSG00000160633 E038 297.020515 1.820424e-04 0.9616455537 0.99119721 19 5667347 5667352 6 + 2.468 2.476 0.026
ENSG00000160633 E039 774.714431 1.528515e-04 0.0948059837 0.44769355 19 5667353 5667450 98 + 2.890 2.876 -0.046
ENSG00000160633 E040 53.718968 1.057133e-01 0.0276884091 0.26978412 19 5667451 5667819 369 + 1.533 1.915 1.293
ENSG00000160633 E041 681.580739 1.338221e-03 0.0772194283 0.41184275 19 5667820 5667886 67 + 2.838 2.809 -0.095
ENSG00000160633 E042 827.478337 9.570712e-04 0.2237881767 0.62868856 19 5668162 5668478 317 + 2.915 2.903 -0.040