ENSG00000160410

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291842 ENSG00000160410 HEK293_DMSO_6hA HEK293_OSMI2_6hA SHKBP1 protein_coding protein_coding 46.22492 43.79709 70.72386 4.226543 10.41077 0.6912364 31.383728 21.856681 51.236997 2.8877910 12.4791679 1.2287332 0.6670625 0.4952333 0.70050000 0.20526667 0.160355979 0.003441621 FALSE  
ENST00000602239 ENSG00000160410 HEK293_DMSO_6hA HEK293_OSMI2_6hA SHKBP1 protein_coding retained_intron 46.22492 43.79709 70.72386 4.226543 10.41077 0.6912364 1.982149 3.786459 2.434213 0.3266808 0.5496617 -0.6352846 0.0343750 0.0870000 0.03463333 -0.05236667 0.003441621 0.003441621 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000160410 E001 0.1125166 0.0319261301 7.909965e-01   19 40576853 40576854 2 + 0.093 0.001 -7.473
ENSG00000160410 E002 1.2794674 0.0135087718 4.929244e-01   19 40576855 40576864 10 + 0.388 0.264 -0.784
ENSG00000160410 E003 1.4339281 0.0217540686 8.493604e-01   19 40576865 40576866 2 + 0.388 0.353 -0.201
ENSG00000160410 E004 3.8797014 0.0071391620 2.469773e-01 0.65246274 19 40576867 40576872 6 + 0.614 0.780 0.690
ENSG00000160410 E005 48.3996287 0.0064139091 1.152087e-01 0.48491558 19 40576873 40576886 14 + 1.732 1.624 -0.364
ENSG00000160410 E006 121.9503545 0.0002932692 1.673097e-02 0.21897107 19 40576887 40576915 29 + 2.114 2.036 -0.262
ENSG00000160410 E007 173.7320722 0.0002293777 2.693583e-02 0.26673301 19 40576916 40576985 70 + 2.259 2.199 -0.201
ENSG00000160410 E008 4.2145709 0.0444725467 3.418928e-01 0.73343485 19 40577082 40577157 76 + 0.656 0.810 0.627
ENSG00000160410 E009 6.4877931 0.0653195254 4.272107e-01 0.79045835 19 40577158 40577175 18 + 0.809 0.952 0.545
ENSG00000160410 E010 6.2439663 0.1100902228 5.795159e-01 0.86667905 19 40577176 40577177 2 + 0.804 0.930 0.484
ENSG00000160410 E011 13.4858133 0.0479848497 2.837476e-01 0.68651669 19 40577178 40577228 51 + 1.081 1.240 0.570
ENSG00000160410 E012 10.8649364 0.0652180352 4.377250e-01 0.79629266 19 40577229 40577230 2 + 1.008 1.134 0.456
ENSG00000160410 E013 232.2704761 0.0001796174 5.512911e-01 0.85451281 19 40577231 40577284 54 + 2.352 2.368 0.055
ENSG00000160410 E014 4.2755471 0.2192660532 6.063779e-01 0.87822625 19 40577285 40577395 111 + 0.655 0.805 0.614
ENSG00000160410 E015 265.1378637 0.0007627256 7.394858e-01 0.92895551 19 40577396 40577441 46 + 2.417 2.413 -0.014
ENSG00000160410 E016 3.3383045 0.3150158856 1.376937e-01 0.52173856 19 40577442 40577556 115 + 0.392 0.851 2.057
ENSG00000160410 E017 344.8736420 0.0004709933 6.322534e-01 0.88888101 19 40577557 40577630 74 + 2.525 2.539 0.044
ENSG00000160410 E018 6.1903992 0.1014448155 5.330914e-02 0.35367758 19 40577631 40577709 79 + 0.668 1.026 1.396
ENSG00000160410 E019 4.4269034 0.4443181696 1.606357e-01 0.55510647 19 40577710 40577929 220 + 0.550 0.903 1.457
ENSG00000160410 E020 5.5458506 0.6328220822 2.203957e-01 0.62493839 19 40578097 40578122 26 + 0.710 0.913 0.799
ENSG00000160410 E021 8.6827069 0.2271171466 3.686083e-01 0.75262719 19 40578123 40578153 31 + 0.895 1.063 0.623
ENSG00000160410 E022 278.3832422 0.0017542152 6.032440e-01 0.87705572 19 40578154 40578195 42 + 2.430 2.448 0.062
ENSG00000160410 E023 210.8387915 0.0015697720 9.225825e-01 0.98151515 19 40578196 40578212 17 + 2.313 2.320 0.024
ENSG00000160410 E024 24.0756776 0.3603913747 1.763318e-02 0.22416384 19 40578213 40578447 235 + 1.088 1.636 1.911
ENSG00000160410 E025 9.6836631 0.0504517525 1.906871e-02 0.23108152 19 40578448 40578461 14 + 0.833 1.198 1.348
ENSG00000160410 E026 347.9862154 0.0001224596 7.729948e-01 0.94028927 19 40578462 40578542 81 + 2.537 2.533 -0.013
ENSG00000160410 E027 1.6870240 0.0143585021 5.466119e-01 0.85251971 19 40580167 40580323 157 + 0.387 0.490 0.541
ENSG00000160410 E028 441.8563351 0.0001969892 3.141698e-01 0.71155146 19 40580324 40580485 162 + 2.646 2.630 -0.054
ENSG00000160410 E029 266.3364695 0.0013654330 1.925747e-01 0.59460695 19 40580566 40580656 91 + 2.430 2.397 -0.107
ENSG00000160410 E030 371.8412988 0.0007055814 4.889633e-01 0.82402567 19 40580746 40580898 153 + 2.565 2.555 -0.031
ENSG00000160410 E031 228.5201982 0.0010742620 8.426657e-01 0.96093996 19 40580899 40580936 38 + 2.345 2.357 0.039
ENSG00000160410 E032 269.9077596 0.0001604498 2.959441e-01 0.69648898 19 40582351 40582425 75 + 2.435 2.413 -0.073
ENSG00000160410 E033 243.5291635 0.0014360643 6.455243e-01 0.89459716 19 40582426 40582466 41 + 2.385 2.375 -0.033
ENSG00000160410 E034 5.3569121 0.1777816924 2.053372e-01 0.60904677 19 40582467 40582515 49 + 0.679 0.933 1.002
ENSG00000160410 E035 268.5679501 0.0001517974 3.965999e-01 0.77083887 19 40583398 40583459 62 + 2.428 2.411 -0.056
ENSG00000160410 E036 190.7913314 0.0001993031 4.213346e-01 0.78693167 19 40583460 40583465 6 + 2.282 2.263 -0.064
ENSG00000160410 E037 228.8509406 0.0001748333 8.326875e-01 0.95780942 19 40583466 40583485 20 + 2.349 2.356 0.025
ENSG00000160410 E038 193.8646562 0.0001782557 7.994918e-01 0.94812876 19 40583601 40583608 8 + 2.283 2.279 -0.016
ENSG00000160410 E039 261.1096933 0.0001426500 7.722973e-01 0.94005756 19 40583609 40583648 40 + 2.406 2.415 0.029
ENSG00000160410 E040 294.6763614 0.0001467819 3.255012e-01 0.72122703 19 40583649 40583717 69 + 2.469 2.450 -0.063
ENSG00000160410 E041 6.1218494 0.3235915724 5.538325e-02 0.35929155 19 40585573 40585817 245 + 0.587 1.062 1.878
ENSG00000160410 E042 11.4560284 0.0717651142 9.130098e-02 0.44074324 19 40586693 40586773 81 + 0.943 1.233 1.052
ENSG00000160410 E043 320.7687630 0.0001265978 3.240736e-01 0.72011496 19 40586774 40586854 81 + 2.507 2.489 -0.060
ENSG00000160410 E044 263.3881025 0.0001465925 3.372973e-01 0.72994112 19 40586855 40586895 41 + 2.423 2.403 -0.066
ENSG00000160410 E045 309.6914570 0.0001655344 8.508209e-01 0.96318803 19 40586896 40586944 49 + 2.483 2.489 0.020
ENSG00000160410 E046 414.5199385 0.0018829902 6.018829e-01 0.87635322 19 40588624 40588738 115 + 2.599 2.625 0.087
ENSG00000160410 E047 254.8639214 0.0017353327 5.441248e-01 0.85172565 19 40588739 40588779 41 + 2.390 2.416 0.085
ENSG00000160410 E048 14.8870737 0.0183285406 1.591997e-04 0.01774097 19 40588780 40588803 24 + 0.975 1.389 1.477
ENSG00000160410 E049 233.0297694 0.0022536648 2.490299e-01 0.65456652 19 40589082 40589100 19 + 2.344 2.390 0.154
ENSG00000160410 E050 321.4629681 0.0012103139 3.019557e-01 0.70145347 19 40589101 40589178 78 + 2.488 2.521 0.109
ENSG00000160410 E051 17.6001818 0.0424431992 6.482264e-05 0.01059166 19 40590209 40590243 35 + 0.979 1.494 1.826
ENSG00000160410 E052 391.4749962 0.0009125464 1.266959e-01 0.50532284 19 40590244 40590422 179 + 2.597 2.567 -0.097
ENSG00000160410 E053 162.2386637 0.0004653924 6.446387e-01 0.89415844 19 40590730 40590732 3 + 2.197 2.214 0.055
ENSG00000160410 E054 381.4043266 0.0011520023 9.169172e-01 0.98014716 19 40590733 40590853 121 + 2.573 2.578 0.016
ENSG00000160410 E055 581.0258282 0.0013949852 9.063883e-01 0.97785587 19 40590976 40591399 424 + 2.752 2.764 0.041