ENSG00000158417

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289371 ENSG00000158417 HEK293_DMSO_6hA HEK293_OSMI2_6hA EIF5B protein_coding protein_coding 46.72257 19.26989 31.03873 5.49596 7.1291 0.6874377 38.962655 14.086126 27.571641 3.868900 7.0022057 0.9684096 0.83564167 0.7350667 0.87413333 0.13906667 0.008152443 0.008152443 FALSE TRUE
ENST00000494190 ENSG00000158417 HEK293_DMSO_6hA HEK293_OSMI2_6hA EIF5B protein_coding retained_intron 46.72257 19.26989 31.03873 5.49596 7.1291 0.6874377 2.666399 3.212859 1.707735 1.416797 0.4136621 -0.9078334 0.06410417 0.1519333 0.06196667 -0.08996667 0.267377857 0.008152443 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000158417 E001 0.2250332 0.0427965941 4.226067e-01   2 99337349 99337370 22 + 0.169 0.000 -11.144
ENSG00000158417 E002 0.2250332 0.0427965941 4.226067e-01   2 99337371 99337378 8 + 0.169 0.000 -11.133
ENSG00000158417 E003 0.4920104 0.1017690435 7.083335e-01   2 99337379 99337379 1 + 0.230 0.152 -0.737
ENSG00000158417 E004 1.9228151 0.0428185853 6.560332e-01 0.89917630 2 99337380 99337388 9 + 0.524 0.428 -0.477
ENSG00000158417 E005 2.0353317 0.0726996214 6.238528e-01 0.88560138 2 99337389 99337390 2 + 0.548 0.428 -0.592
ENSG00000158417 E006 33.1627874 0.0115251287 1.641534e-01 0.55930658 2 99337391 99337418 28 + 1.576 1.458 -0.402
ENSG00000158417 E007 180.6636279 0.0077587519 5.085500e-01 0.83395651 2 99337419 99337589 171 + 2.265 2.232 -0.111
ENSG00000158417 E008 187.6808591 0.0070372438 9.545048e-01 0.98947804 2 99360236 99360361 126 + 2.270 2.268 -0.007
ENSG00000158417 E009 168.5780716 0.0049172496 8.301606e-01 0.95690313 2 99360465 99360549 85 + 2.222 2.233 0.038
ENSG00000158417 E010 615.8274226 0.0005892721 3.162441e-01 0.71336605 2 99361148 99361820 673 + 2.779 2.799 0.065
ENSG00000158417 E011 141.3260498 0.0171998352 4.803298e-01 0.81939136 2 99363645 99363862 218 + 2.122 2.181 0.199
ENSG00000158417 E012 181.7049006 0.0032023298 6.506791e-01 0.89674698 2 99364271 99364421 151 + 2.251 2.272 0.072
ENSG00000158417 E013 226.3524929 0.0005110093 8.462860e-01 0.96190022 2 99368493 99368591 99 + 2.361 2.355 -0.019
ENSG00000158417 E014 242.5710280 0.0001511642 8.001548e-01 0.94832488 2 99369392 99369481 90 + 2.383 2.388 0.018
ENSG00000158417 E015 0.3375497 0.2337173331 3.345374e-01   2 99369482 99369485 4 + 0.226 0.000 -11.656
ENSG00000158417 E016 0.0000000       2 99371138 99371139 2 +      
ENSG00000158417 E017 147.1770465 0.0002377771 5.302820e-01 0.84511133 2 99371656 99371661 6 + 2.177 2.158 -0.063
ENSG00000158417 E018 219.6282619 0.0001626442 7.596151e-01 0.93573488 2 99371662 99371709 48 + 2.347 2.339 -0.027
ENSG00000158417 E019 183.1999122 0.0002091129 9.794425e-01 0.99506779 2 99371710 99371730 21 + 2.265 2.265 -0.002
ENSG00000158417 E020 126.4216227 0.0019329517 9.474333e-01 0.98770841 2 99376347 99376349 3 + 2.108 2.101 -0.023
ENSG00000158417 E021 272.7964408 0.0007441229 5.479783e-01 0.85319120 2 99376350 99376464 115 + 2.430 2.444 0.046
ENSG00000158417 E022 164.8571656 0.0010063216 4.111235e-01 0.78107902 2 99376465 99376478 14 + 2.207 2.231 0.082
ENSG00000158417 E023 349.4938302 0.0006000621 7.175539e-01 0.92130469 2 99376479 99376636 158 + 2.538 2.546 0.025
ENSG00000158417 E024 264.2806830 0.0001449791 4.008768e-01 0.77390477 2 99379019 99379126 108 + 2.431 2.411 -0.065
ENSG00000158417 E025 220.3567404 0.0001656921 3.263138e-01 0.72181247 2 99379318 99379428 111 + 2.355 2.331 -0.082
ENSG00000158417 E026 174.3034782 0.0034598190 1.046656e-01 0.46610088 2 99382159 99382226 68 + 2.258 2.208 -0.169
ENSG00000158417 E027 260.1162116 0.0001569095 3.421125e-01 0.73359560 2 99382780 99382921 142 + 2.426 2.404 -0.073
ENSG00000158417 E028 0.7922866 0.0584734829 8.846913e-01   2 99389607 99389717 111 + 0.235 0.265 0.226
ENSG00000158417 E029 259.4368532 0.0012784603 8.519952e-01 0.96341396 2 99389718 99389849 132 + 2.407 2.414 0.026
ENSG00000158417 E030 310.4809660 0.0001380739 8.384053e-01 0.95966222 2 99390219 99390401 183 + 2.494 2.489 -0.016
ENSG00000158417 E031 333.5280423 0.0001160261 5.681864e-01 0.86149447 2 99390544 99390705 162 + 2.520 2.531 0.035
ENSG00000158417 E032 289.1653836 0.0001503069 8.791741e-01 0.97096969 2 99392967 99393098 132 + 2.463 2.459 -0.012
ENSG00000158417 E033 274.4346391 0.0021297376 6.026243e-01 0.87679508 2 99394267 99394398 132 + 2.438 2.429 -0.033
ENSG00000158417 E034 226.5889627 0.0055622064 9.140533e-01 0.97942057 2 99394509 99394585 77 + 2.346 2.358 0.040
ENSG00000158417 E035 256.2324800 0.0069403550 5.976329e-01 0.87464552 2 99394719 99394808 90 + 2.410 2.390 -0.070
ENSG00000158417 E036 204.3278663 0.0025237502 2.263039e-01 0.63144017 2 99394809 99394883 75 + 2.321 2.281 -0.132
ENSG00000158417 E037 298.1755333 0.0042634194 6.074009e-01 0.87862338 2 99396760 99396898 139 + 2.473 2.463 -0.034
ENSG00000158417 E038 25.0985494 0.1642520617 1.604821e-02 0.21517379 2 99397047 99398747 1701 + 1.158 1.629 1.634
ENSG00000158417 E039 269.2091942 0.0025229448 7.764411e-01 0.94117780 2 99398748 99398850 103 + 2.422 2.436 0.048
ENSG00000158417 E040 201.9872841 0.0015702762 7.869556e-01 0.94424191 2 99398851 99398909 59 + 2.301 2.310 0.030
ENSG00000158417 E041 20.8725644 0.0280039096 6.770018e-05 0.01086363 2 99398910 99399197 288 + 1.084 1.552 1.636
ENSG00000158417 E042 154.8599594 0.0003425771 8.540265e-01 0.96386930 2 99399307 99399311 5 + 2.193 2.186 -0.022
ENSG00000158417 E043 565.4473192 0.0014449011 6.472597e-01 0.89538079 2 99399312 99401326 2015 + 2.742 2.755 0.044