ENSG00000157764

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000469930 ENSG00000157764 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRAF protein_coding protein_coding 5.215004 2.360468 3.679125 0.5112868 0.9642693 0.6381066 0.4993367 0.27852366 0.4742644 0.05742247 0.1180390 0.74710536 0.11699583 0.11870000 0.13210000 0.01340000 0.90583677 0.00399451 FALSE TRUE
ENST00000496384 ENSG00000157764 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRAF protein_coding protein_coding 5.215004 2.360468 3.679125 0.5112868 0.9642693 0.6381066 2.4870614 1.55765010 1.6374728 0.48250134 0.4283780 0.07165107 0.47384583 0.63533333 0.45060000 -0.18473333 0.32265443 0.00399451 FALSE TRUE
ENST00000642228 ENSG00000157764 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRAF protein_coding nonsense_mediated_decay 5.215004 2.360468 3.679125 0.5112868 0.9642693 0.6381066 0.3039178 0.01443059 0.6723913 0.01443059 0.2412444 4.80383875 0.06947917 0.00830000 0.18826667 0.17996667 0.00399451 0.00399451 FALSE TRUE
ENST00000647434 ENSG00000157764 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRAF protein_coding nonsense_mediated_decay 5.215004 2.360468 3.679125 0.5112868 0.9642693 0.6381066 0.7784598 0.22446456 0.4522337 0.01628093 0.3808570 0.97925247 0.14559583 0.10220000 0.11110000 0.00890000 0.86132517 0.00399451 TRUE TRUE
MSTRG.30832.5 ENSG00000157764 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRAF protein_coding   5.215004 2.360468 3.679125 0.5112868 0.9642693 0.6381066 0.7502155 0.11221056 0.2201156 0.06133406 0.1234362 0.91299003 0.11971667 0.06173333 0.04696667 -0.01476667 0.99257036 0.00399451 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000157764 E001 0.2669773 0.0262484403 8.574243e-01   7 140719327 140719336 10 - 0.100 0.143 0.591
ENSG00000157764 E002 296.4786779 0.0103206646 3.947552e-06 0.001569305 7 140719337 140725144 5808 - 2.349 2.592 0.809
ENSG00000157764 E003 9.5949613 0.0030110875 3.286846e-01 0.723479429 7 140725145 140725324 180 - 1.054 1.014 -0.146
ENSG00000157764 E004 4.6775527 0.0058257008 1.533638e-02 0.210593705 7 140725325 140725429 105 - 0.857 0.570 -1.190
ENSG00000157764 E005 45.3777255 0.0006409202 1.179648e-01 0.489859273 7 140725430 140726516 1087 - 1.602 1.746 0.491
ENSG00000157764 E006 1.6691536 0.0111814313 4.829794e-01 0.820929207 7 140730665 140732562 1898 - 0.360 0.522 0.852
ENSG00000157764 E007 4.9659896 0.0049568259 8.622062e-02 0.430328315 7 140732563 140734313 1751 - 0.639 0.923 1.136
ENSG00000157764 E008 2.5083894 0.0085974711 2.393385e-01 0.644541013 7 140734314 140734485 172 - 0.612 0.469 -0.672
ENSG00000157764 E009 0.4481873 0.0217681645 7.242764e-01   7 140734486 140734486 1 - 0.181 0.143 -0.412
ENSG00000157764 E010 0.7374745 0.0174214615 2.696247e-01   7 140734487 140734520 34 - 0.308 0.143 -1.411
ENSG00000157764 E011 1.3094092 0.0299138558 5.461806e-01   7 140734521 140734557 37 - 0.405 0.336 -0.402
ENSG00000157764 E012 2.8999108 0.0072792729 1.244680e-01 0.501360624 7 140734558 140734596 39 - 0.664 0.469 -0.895
ENSG00000157764 E013 3.2419000 0.0066696090 4.560970e-02 0.331790059 7 140734597 140734616 20 - 0.731 0.469 -1.173
ENSG00000157764 E014 17.8021812 0.0151135627 3.489344e-01 0.738547630 7 140734617 140734770 154 - 1.290 1.249 -0.145
ENSG00000157764 E015 21.9206117 0.0593131529 9.262082e-01 0.982551367 7 140739812 140739946 135 - 1.351 1.360 0.032
ENSG00000157764 E016 0.1812101 0.0342044803 6.014178e-01   7 140739947 140741717 1771 - 0.100 0.000 -12.662
ENSG00000157764 E017 0.0000000       7 140747366 140747447 82 -      
ENSG00000157764 E018 0.0000000       7 140748932 140749052 121 -      
ENSG00000157764 E019 19.8109058 0.0142052971 2.107439e-03 0.081851262 7 140749287 140749418 132 - 1.397 1.153 -0.856
ENSG00000157764 E020 18.6719566 0.0056340935 9.878550e-04 0.053653383 7 140753275 140753393 119 - 1.367 1.141 -0.797
ENSG00000157764 E021 0.4884942 0.0215529528 5.569175e-02   7 140753394 140754186 793 - 0.000 0.335 14.152
ENSG00000157764 E022 15.8650230 0.0111321711 2.547090e-01 0.660468041 7 140754187 140754233 47 - 1.235 1.187 -0.169
ENSG00000157764 E023 0.1717682 0.0477281093 3.950342e-01   7 140758100 140758290 191 - 0.000 0.143 12.519
ENSG00000157764 E024 0.1812101 0.0342044803 6.014178e-01   7 140773267 140773406 140 - 0.100 0.000 -12.662
ENSG00000157764 E025 31.3374087 0.0011632897 4.302235e-02 0.323687681 7 140776912 140777088 177 - 1.532 1.474 -0.201
ENSG00000157764 E026 23.6694186 0.0014585294 1.773137e-01 0.575953931 7 140777991 140778075 85 - 1.407 1.379 -0.098
ENSG00000157764 E027 0.0000000       7 140779807 140779928 122 -      
ENSG00000157764 E028 0.1717682 0.0477281093 3.950342e-01   7 140780359 140781575 1217 - 0.000 0.143 12.519
ENSG00000157764 E029 24.7984151 0.0053730333 9.387550e-01 0.985654890 7 140781576 140781693 118 - 1.372 1.449 0.268
ENSG00000157764 E030 24.6708303 0.0015461155 5.807140e-01 0.867209525 7 140783021 140783157 137 - 1.357 1.462 0.364
ENSG00000157764 E031 0.3535412 0.9170901901 4.921182e-01   7 140783158 140783464 307 - 0.192 0.000 -12.553
ENSG00000157764 E032 0.1125166 0.0323016068 6.031801e-01   7 140785689 140785808 120 - 0.100 0.000 -12.669
ENSG00000157764 E033 12.6874400 0.0046921152 5.498606e-01 0.853986282 7 140787548 140787584 37 - 1.091 1.208 0.421
ENSG00000157764 E034 19.3285248 0.0135641311 3.048160e-01 0.703717918 7 140794308 140794415 108 - 1.329 1.293 -0.124
ENSG00000157764 E035 14.2629198 0.0087832187 2.033909e-01 0.607248823 7 140794416 140794467 52 - 1.215 1.153 -0.220
ENSG00000157764 E036 1.1368363 0.0327627467 9.588406e-01   7 140799054 140800361 1308 - 0.309 0.335 0.165
ENSG00000157764 E037 17.7760849 0.0017716233 7.494268e-03 0.152245637 7 140800362 140800462 101 - 1.340 1.187 -0.539
ENSG00000157764 E038 8.5699441 0.0029319538 4.509905e-02 0.330239432 7 140800463 140800481 19 - 1.044 0.881 -0.608
ENSG00000157764 E039 0.0000000       7 140801020 140801411 392 -      
ENSG00000157764 E040 18.9901769 0.0014617277 2.140935e-04 0.021282072 7 140801412 140801560 149 - 1.385 1.153 -0.815
ENSG00000157764 E041 18.6544519 0.0015193692 6.169456e-03 0.139229203 7 140807960 140808062 103 - 1.351 1.198 -0.538
ENSG00000157764 E042 0.2892872 0.0266627670 2.778019e-01   7 140808063 140808236 174 - 0.181 0.000 -13.650
ENSG00000157764 E043 0.1717682 0.0477281093 3.950342e-01   7 140808237 140808316 80 - 0.000 0.143 12.519
ENSG00000157764 E044 0.0000000       7 140808317 140808338 22 -      
ENSG00000157764 E045 0.1125166 0.0323016068 6.031801e-01   7 140808883 140808891 9 - 0.100 0.000 -12.669
ENSG00000157764 E046 18.7446586 0.0014766909 8.762017e-03 0.163286670 7 140808892 140808995 104 - 1.351 1.208 -0.501
ENSG00000157764 E047 0.2937266 0.0274424043 2.805395e-01   7 140822385 140822452 68 - 0.181 0.000 -13.645
ENSG00000157764 E048 1.0188059 0.6230084966 8.113218e-01   7 140823533 140824398 866 - 0.264 0.333 0.461
ENSG00000157764 E049 0.0000000       7 140833969 140833971 3 -      
ENSG00000157764 E050 9.5784431 0.0029100109 9.378013e-01 0.985432833 7 140833972 140834608 637 - 0.991 1.045 0.200
ENSG00000157764 E051 21.0324040 0.0014839365 6.139277e-01 0.881762495 7 140834609 140834703 95 - 1.330 1.357 0.093
ENSG00000157764 E052 20.0093250 0.0405797790 4.489686e-01 0.803054121 7 140834704 140834872 169 - 1.353 1.292 -0.212
ENSG00000157764 E053 0.3513410 0.0306292282 1.459882e-01   7 140834873 140836233 1361 - 0.000 0.250 13.559
ENSG00000157764 E054 12.6230583 0.0091369469 1.838225e-02 0.228084394 7 140850111 140850212 102 - 1.214 1.029 -0.664
ENSG00000157764 E055 9.5372568 0.0027190724 5.262959e-01 0.843235476 7 140924566 140924929 364 - 1.034 1.030 -0.014