ENSG00000157110

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339877 ENSG00000157110 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBPMS protein_coding protein_coding 5.828755 4.094188 7.821414 0.5414215 0.7188488 0.9321761 3.0812398 1.6683228 5.3931561 0.28401958 1.23439797 1.6867821 0.53362917 0.40963333 0.67250000 0.26286667 2.527158e-01 2.461487e-10 FALSE TRUE
ENST00000397323 ENSG00000157110 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBPMS protein_coding protein_coding 5.828755 4.094188 7.821414 0.5414215 0.7188488 0.9321761 0.2881857 0.1692943 0.4338543 0.03355624 0.12442005 1.3077564 0.05271667 0.04086667 0.05346667 0.01260000 8.594847e-01 2.461487e-10 TRUE TRUE
ENST00000519647 ENSG00000157110 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBPMS protein_coding protein_coding 5.828755 4.094188 7.821414 0.5414215 0.7188488 0.9321761 1.1070172 1.0173051 0.0000000 0.35582419 0.00000000 -6.6827209 0.17335417 0.23930000 0.00000000 -0.23930000 2.461487e-10 2.461487e-10 FALSE TRUE
ENST00000519657 ENSG00000157110 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBPMS protein_coding processed_transcript 5.828755 4.094188 7.821414 0.5414215 0.7188488 0.9321761 0.1537939 0.3277519 0.2293766 0.01252254 0.07252039 -0.4966817 0.02825833 0.08230000 0.02813333 -0.05416667 2.942674e-01 2.461487e-10   FALSE
ENST00000523115 ENSG00000157110 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBPMS protein_coding protein_coding 5.828755 4.094188 7.821414 0.5414215 0.7188488 0.9321761 0.3770335 0.0000000 0.8488138 0.00000000 0.84881379 6.4242735 0.06155417 0.00000000 0.12846667 0.12846667 8.342110e-01 2.461487e-10 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000157110 E001 4.2668436 0.0056583836 3.894693e-01 0.76661280 8 30384511 30384526 16 + 0.760 0.641 -0.492
ENSG00000157110 E002 5.1867542 0.0077554250 8.969093e-01 0.97547436 8 30384527 30384540 14 + 0.794 0.783 -0.041
ENSG00000157110 E003 44.8291689 0.0081752312 6.591314e-03 0.14299538 8 30384541 30385084 544 + 1.713 1.537 -0.598
ENSG00000157110 E004 24.9686109 0.0012547160 1.218080e-02 0.19058501 8 30385085 30385158 74 + 1.463 1.292 -0.592
ENSG00000157110 E005 0.1767706 0.0464889945 8.133700e-01   8 30385203 30385390 188 + 0.093 0.000 -7.728
ENSG00000157110 E006 0.0000000       8 30387064 30387118 55 +      
ENSG00000157110 E007 0.0000000       8 30387208 30387324 117 +      
ENSG00000157110 E008 0.0000000       8 30397927 30397986 60 +      
ENSG00000157110 E009 0.0000000       8 30442617 30442719 103 +      
ENSG00000157110 E010 0.0000000       8 30442720 30442800 81 +      
ENSG00000157110 E011 0.0000000       8 30444676 30444880 205 +      
ENSG00000157110 E012 0.0000000       8 30445234 30445349 116 +      
ENSG00000157110 E013 0.0000000       8 30446943 30446966 24 +      
ENSG00000157110 E014 0.0000000       8 30453660 30453805 146 +      
ENSG00000157110 E015 16.8889247 0.0029521200 1.843116e-01 0.58472058 8 30474779 30474785 7 + 1.280 1.175 -0.371
ENSG00000157110 E016 30.2492667 0.0011731296 1.455538e-01 0.53312658 8 30474786 30474856 71 + 1.519 1.435 -0.290
ENSG00000157110 E017 28.3572258 0.0011210465 2.316700e-01 0.63668139 8 30477799 30477837 39 + 1.484 1.414 -0.241
ENSG00000157110 E018 21.9796652 0.0013476692 3.395162e-01 0.73149236 8 30479315 30479329 15 + 1.373 1.311 -0.216
ENSG00000157110 E019 32.8469163 0.0011080628 8.109487e-02 0.41983748 8 30479330 30479377 48 + 1.553 1.454 -0.337
ENSG00000157110 E020 66.8865338 0.0005384309 1.209668e-01 0.49543173 8 30504286 30504436 151 + 1.844 1.788 -0.189
ENSG00000157110 E021 0.0000000       8 30537578 30537723 146 +      
ENSG00000157110 E022 62.6002894 0.0040693686 9.352614e-01 0.98477063 8 30544494 30544624 131 + 1.788 1.804 0.053
ENSG00000157110 E023 5.9173479 0.0043634651 3.326366e-02 0.29144444 8 30544625 30545163 539 + 0.703 0.976 1.064
ENSG00000157110 E024 2.1616396 0.0440875018 7.148342e-01 0.92029273 8 30545164 30545199 36 + 0.491 0.548 0.271
ENSG00000157110 E025 1.6779967 0.0132747193 9.983421e-01 0.99954603 8 30545200 30545220 21 + 0.425 0.430 0.025
ENSG00000157110 E026 3.3966825 0.0787695545 3.941885e-01 0.76949516 8 30545221 30545465 245 + 0.561 0.719 0.685
ENSG00000157110 E027 1.0327483 0.1155471460 5.732703e-01   8 30545466 30545591 126 + 0.238 0.355 0.795
ENSG00000157110 E028 34.5095775 0.0010066307 4.720137e-01 0.81496330 8 30547292 30547522 231 + 1.522 1.572 0.171
ENSG00000157110 E029 2.4945908 0.0103492174 4.341766e-01 0.79397657 8 30549500 30549585 86 + 0.464 0.597 0.633
ENSG00000157110 E030 3.8531176 0.1975576836 2.934430e-01 0.69426543 8 30556453 30556636 184 + 0.574 0.785 0.890
ENSG00000157110 E031 3.9013801 0.0866953078 2.993899e-01 0.69946873 8 30556637 30556794 158 + 0.590 0.784 0.815
ENSG00000157110 E032 0.3968013 0.0366340486 9.908358e-01   8 30556795 30556798 4 + 0.168 0.153 -0.161
ENSG00000157110 E033 9.0385810 0.0031393323 4.213261e-03 0.11634855 8 30558181 30558886 706 + 0.855 1.162 1.132
ENSG00000157110 E034 11.2133984 0.0027482011 1.449943e-01 0.53219179 8 30558887 30558956 70 + 1.011 1.162 0.547
ENSG00000157110 E035 0.6792071 0.0296487787 1.255223e-01   8 30561944 30562149 206 + 0.093 0.355 2.410
ENSG00000157110 E036 2.0521172 0.8348538274 4.748095e-01 0.81659140 8 30564050 30564366 317 + 0.460 0.488 0.141
ENSG00000157110 E037 1.9906654 0.3672584175 4.237887e-01 0.78852012 8 30564367 30564452 86 + 0.398 0.546 0.747
ENSG00000157110 E038 5.8082182 0.1048084899 8.995982e-02 0.43849688 8 30564453 30566256 1804 + 0.652 0.979 1.292
ENSG00000157110 E039 10.5841885 0.0026921574 4.664260e-03 0.12264248 8 30566257 30566360 104 + 0.922 1.210 1.049
ENSG00000157110 E040 33.2756464 0.0165322812 7.154775e-05 0.01117245 8 30570637 30572256 1620 + 1.371 1.693 1.103