ENSG00000156639

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287218 ENSG00000156639 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND3 protein_coding protein_coding 29.1985 22.4328 34.22403 3.335167 5.789365 0.6091786 9.147070 4.635521 14.263401 0.5014582 2.1459151 1.6194170 0.30889583 0.2205000 0.4212333 0.200733333 0.04579964 0.04579964 FALSE TRUE
ENST00000373389 ENSG00000156639 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND3 protein_coding protein_coding 29.1985 22.4328 34.22403 3.335167 5.789365 0.6091786 8.945124 7.482286 8.732761 2.8429638 1.8831669 0.2226831 0.30634167 0.3119667 0.2543000 -0.057666667 0.75421737 0.04579964 FALSE TRUE
ENST00000373391 ENSG00000156639 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND3 protein_coding protein_coding 29.1985 22.4328 34.22403 3.335167 5.789365 0.6091786 3.055603 2.441579 3.947062 0.1536089 0.4089082 0.6907188 0.10735417 0.1154667 0.1185000 0.003033333 0.96244753 0.04579964 FALSE TRUE
ENST00000440482 ENSG00000156639 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND3 protein_coding processed_transcript 29.1985 22.4328 34.22403 3.335167 5.789365 0.6091786 1.513301 2.813052 0.000000 2.0843519 0.0000000 -8.1411119 0.04579583 0.1043667 0.0000000 -0.104366667 0.37883937 0.04579964 FALSE FALSE
MSTRG.28232.3 ENSG00000156639 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND3 protein_coding   29.1985 22.4328 34.22403 3.335167 5.789365 0.6091786 4.567455 3.521004 5.302166 1.0283854 1.8200935 0.5892217 0.16123750 0.1768333 0.1476333 -0.029200000 0.95942933 0.04579964 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000156639 E001 10.5288219 0.0025115919 4.149579e-01 0.783426447 6 37819727 37819797 71 + 1.090 1.008 -0.297
ENSG00000156639 E002 4.4100377 0.0052896993 4.113444e-02 0.317793201 6 37819798 37819840 43 + 0.831 0.531 -1.266
ENSG00000156639 E003 2.3035785 0.0991098795 7.446823e-01 0.930993426 6 37819841 37819845 5 + 0.543 0.478 -0.313
ENSG00000156639 E004 29.5741587 0.0010697510 2.429619e-02 0.255548514 6 37819846 37819941 96 + 1.530 1.384 -0.505
ENSG00000156639 E005 60.1273475 0.0045140023 5.735761e-02 0.364653472 6 37819942 37820016 75 + 1.815 1.711 -0.350
ENSG00000156639 E006 74.5206965 0.0004999124 6.265605e-02 0.378832821 6 37929959 37929999 41 + 1.893 1.818 -0.253
ENSG00000156639 E007 0.4018037 0.0239435005 1.821299e-01   6 38003691 38003783 93 + 0.243 0.000 -9.745
ENSG00000156639 E008 80.4496847 0.0003904639 1.990359e-01 0.602218799 6 38061593 38061610 18 + 1.919 1.870 -0.162
ENSG00000156639 E009 246.6591833 0.0004814719 4.197602e-01 0.785868960 6 38061611 38061775 165 + 2.388 2.372 -0.052
ENSG00000156639 E010 0.9221107 0.1048223403 7.863769e-01   6 38062408 38062660 253 + 0.301 0.256 -0.321
ENSG00000156639 E011 181.5215531 0.0002266750 3.915435e-01 0.767974059 6 38082392 38082457 66 + 2.258 2.238 -0.065
ENSG00000156639 E012 0.0000000       6 38088331 38088373 43 +      
ENSG00000156639 E013 259.0570856 0.0001783921 1.029255e-01 0.462564630 6 38116572 38116739 168 + 2.420 2.388 -0.108
ENSG00000156639 E014 1.1732666 0.6622196398 5.103277e-01   6 38142259 38142331 73 + 0.259 0.409 0.942
ENSG00000156639 E015 1.5968783 0.2657380609 6.784558e-01   6 38142997 38143204 208 + 0.354 0.477 0.666
ENSG00000156639 E016 1384.6000192 0.0002128178 1.295298e-05 0.003681691 6 38152235 38154624 2390 + 3.119 3.152 0.108