ENSG00000154889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344987 ENSG00000154889 HEK293_DMSO_6hA HEK293_OSMI2_6hA MPPE1 protein_coding protein_coding 15.35389 14.06155 14.75893 0.4629421 0.2407147 0.06978435 1.842545 1.7089937 1.4919140 0.2412724 0.1443239 -0.1947621 0.12349583 0.12206667 0.10140000 -0.02066667 0.78205899 0.03638835 FALSE TRUE
ENST00000589859 ENSG00000154889 HEK293_DMSO_6hA HEK293_OSMI2_6hA MPPE1 protein_coding protein_coding 15.35389 14.06155 14.75893 0.4629421 0.2407147 0.06978435 0.343059 1.1754029 0.3753633 0.2303512 0.3204618 -1.6210863 0.02333750 0.08270000 0.02533333 -0.05736667 0.32346171 0.03638835   FALSE
ENST00000592447 ENSG00000154889 HEK293_DMSO_6hA HEK293_OSMI2_6hA MPPE1 protein_coding retained_intron 15.35389 14.06155 14.75893 0.4629421 0.2407147 0.06978435 0.676766 1.2249708 0.5269678 0.3580129 0.2980051 -1.2015694 0.04620833 0.08570000 0.03523333 -0.05046667 0.62123739 0.03638835 TRUE TRUE
ENST00000592755 ENSG00000154889 HEK293_DMSO_6hA HEK293_OSMI2_6hA MPPE1 protein_coding processed_transcript 15.35389 14.06155 14.75893 0.4629421 0.2407147 0.06978435 0.899163 1.2320820 0.6016437 0.1816928 0.3357549 -1.0219970 0.05921250 0.08740000 0.04150000 -0.04590000 0.64276865 0.03638835   FALSE
ENST00000593001 ENSG00000154889 HEK293_DMSO_6hA HEK293_OSMI2_6hA MPPE1 protein_coding non_stop_decay 15.35389 14.06155 14.75893 0.4629421 0.2407147 0.06978435 5.178953 2.4648573 6.8517165 0.3816488 1.3782216 1.4712242 0.32128333 0.17670000 0.46426667 0.28756667 0.03638835 0.03638835   FALSE
MSTRG.15516.12 ENSG00000154889 HEK293_DMSO_6hA HEK293_OSMI2_6hA MPPE1 protein_coding   15.35389 14.06155 14.75893 0.4629421 0.2407147 0.06978435 1.010123 0.8489895 0.4126896 0.4344546 0.2115708 -1.0230416 0.06539167 0.06086667 0.02796667 -0.03290000 0.87785254 0.03638835 FALSE TRUE
MSTRG.15516.5 ENSG00000154889 HEK293_DMSO_6hA HEK293_OSMI2_6hA MPPE1 protein_coding   15.35389 14.06155 14.75893 0.4629421 0.2407147 0.06978435 1.050653 1.0090391 0.7997545 0.1572885 0.1900853 -0.3316530 0.06851667 0.07130000 0.05426667 -0.01703333 0.75498768 0.03638835 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000154889 E001 0.7995283 0.0167450878 9.596050e-01   18 11882622 11883118 497 - 0.244 0.255 0.089
ENSG00000154889 E002 0.7453401 0.0931664960 4.401451e-01   18 11883119 11883470 352 - 0.326 0.186 -1.065
ENSG00000154889 E003 5.1249069 0.0045982013 9.313351e-01 0.983644207 18 11883471 11883689 219 - 0.771 0.764 -0.029
ENSG00000154889 E004 11.6370782 0.0086514869 1.717282e-01 0.569206461 18 11883690 11884052 363 - 0.986 1.140 0.558
ENSG00000154889 E005 5.1453849 0.0044689935 1.320833e-01 0.513546789 18 11884053 11884067 15 - 0.642 0.854 0.859
ENSG00000154889 E006 15.5318399 0.0031933124 6.172701e-01 0.882851777 18 11884068 11884165 98 - 1.226 1.188 -0.138
ENSG00000154889 E007 14.8250787 0.0182494061 8.712378e-01 0.968489677 18 11884166 11884194 29 - 1.190 1.179 -0.042
ENSG00000154889 E008 29.9804944 0.0011360707 3.038422e-01 0.702977797 18 11884195 11884306 112 - 1.426 1.497 0.247
ENSG00000154889 E009 71.4909241 0.0005270696 1.116577e-01 0.478538220 18 11884307 11884489 183 - 1.803 1.875 0.242
ENSG00000154889 E010 67.8806493 0.0046815981 3.660399e-01 0.750875334 18 11884490 11884627 138 - 1.797 1.847 0.171
ENSG00000154889 E011 3.6619027 0.1429259082 6.647804e-01 0.902219502 18 11884877 11884878 2 - 0.611 0.677 0.285
ENSG00000154889 E012 12.0908655 0.0424096952 8.076702e-01 0.950699798 18 11884879 11884892 14 - 1.088 1.122 0.123
ENSG00000154889 E013 22.2201641 0.0259363825 1.427571e-01 0.529196505 18 11884893 11885043 151 - 1.256 1.407 0.527
ENSG00000154889 E014 9.7096741 0.1551646268 3.389829e-01 0.731133263 18 11885044 11885121 78 - 0.916 1.071 0.571
ENSG00000154889 E015 38.3664189 0.0084061340 3.573505e-01 0.745028517 18 11885676 11885759 84 - 1.543 1.607 0.219
ENSG00000154889 E016 34.9808348 0.0007807128 8.218796e-01 0.955002906 18 11885760 11885816 57 - 1.547 1.539 -0.027
ENSG00000154889 E017 8.5980804 0.0028036133 5.612519e-02 0.361311299 18 11885817 11885912 96 - 0.822 1.047 0.845
ENSG00000154889 E018 5.2838944 0.0629222961 9.953863e-01 0.998761747 18 11885913 11886114 202 - 0.781 0.780 -0.003
ENSG00000154889 E019 15.4246325 0.0622194609 3.351379e-01 0.728313584 18 11886115 11886498 384 - 1.116 1.248 0.469
ENSG00000154889 E020 51.4143252 0.0007500265 5.534032e-01 0.855233145 18 11886499 11886621 123 - 1.715 1.691 -0.083
ENSG00000154889 E021 9.4780752 0.1382198236 9.532091e-01 0.989143432 18 11886622 11886712 91 - 1.052 0.975 -0.286
ENSG00000154889 E022 18.0817257 0.0130897690 1.943512e-01 0.596922256 18 11886713 11886720 8 - 1.179 1.306 0.445
ENSG00000154889 E023 25.3425830 0.0034650047 4.407714e-01 0.798131899 18 11886721 11886778 58 - 1.361 1.421 0.208
ENSG00000154889 E024 8.5409851 0.0031415005 5.754431e-01 0.864598000 18 11886779 11886781 3 - 0.912 0.980 0.253
ENSG00000154889 E025 13.1581406 0.0680333106 1.173933e-01 0.488918757 18 11886782 11886916 135 - 0.996 1.207 0.765
ENSG00000154889 E026 49.4245562 0.0027174485 3.437334e-02 0.295250423 18 11886917 11887025 109 - 1.612 1.735 0.418
ENSG00000154889 E027 31.1441275 0.0136678324 1.743581e-01 0.572166659 18 11888669 11888703 35 - 1.422 1.542 0.412
ENSG00000154889 E028 32.9448516 0.0124825045 2.400713e-01 0.645230511 18 11888704 11888743 40 - 1.455 1.558 0.354
ENSG00000154889 E029 36.4847460 0.0047613533 9.678459e-01 0.992567717 18 11889387 11889455 69 - 1.553 1.563 0.034
ENSG00000154889 E030 34.3557816 0.0008607408 9.824434e-01 0.995765579 18 11889456 11889490 35 - 1.529 1.533 0.014
ENSG00000154889 E031 1.5485548 0.0149815886 3.971676e-01   18 11891186 11891470 285 - 0.461 0.315 -0.826
ENSG00000154889 E032 1.5776342 0.0191249382 2.406398e-01   18 11893048 11893467 420 - 0.244 0.458 1.310
ENSG00000154889 E033 44.4737405 0.0007507380 6.208391e-01 0.884460841 18 11893468 11893566 99 - 1.650 1.630 -0.070
ENSG00000154889 E034 21.5928606 0.0014475837 7.732744e-01 0.940422304 18 11893567 11893576 10 - 1.344 1.328 -0.056
ENSG00000154889 E035 1.6230912 0.2464138408 2.893093e-01   18 11895185 11895277 93 - 0.526 0.311 -1.172
ENSG00000154889 E036 0.0000000       18 11896983 11896983 1 -      
ENSG00000154889 E037 20.9835120 0.0024139640 9.554449e-01 0.989746706 18 11896984 11896988 5 - 1.322 1.323 0.004
ENSG00000154889 E038 23.0553786 0.0039104049 4.413029e-01 0.798399256 18 11896989 11897035 47 - 1.394 1.339 -0.191
ENSG00000154889 E039 14.5212424 0.0091314256 5.870455e-01 0.870090509 18 11897036 11897055 20 - 1.198 1.149 -0.174
ENSG00000154889 E040 13.4410032 0.0020562242 1.737043e-01 0.571333653 18 11897056 11897058 3 - 1.206 1.087 -0.428
ENSG00000154889 E041 17.3169107 0.0071232704 1.666324e-01 0.562709122 18 11897059 11897120 62 - 1.309 1.188 -0.425
ENSG00000154889 E042 7.6009675 0.0033800285 3.691058e-01 0.753101877 18 11897121 11897131 11 - 0.968 0.870 -0.373
ENSG00000154889 E043 8.9659637 0.0191889698 4.799717e-01 0.819186461 18 11897132 11897185 54 - 1.022 0.943 -0.294
ENSG00000154889 E044 22.0858288 0.0669119818 2.933092e-01 0.694134279 18 11897186 11897299 114 - 1.431 1.292 -0.482
ENSG00000154889 E045 25.6913040 0.0117373548 6.899306e-02 0.393598966 18 11897300 11897326 27 - 1.494 1.351 -0.494
ENSG00000154889 E046 32.3130909 0.0170496877 7.514441e-02 0.407290927 18 11897327 11897356 30 - 1.591 1.449 -0.487
ENSG00000154889 E047 17.3873033 0.0015959395 7.740477e-01 0.940612850 18 11897526 11897620 95 - 1.235 1.264 0.101
ENSG00000154889 E048 2.5243815 0.0299389157 5.471093e-01 0.852765653 18 11902267 11902358 92 - 0.461 0.565 0.499
ENSG00000154889 E049 6.5890985 0.2899545954 2.868013e-01 0.688919620 18 11902585 11902748 164 - 0.802 0.899 0.375
ENSG00000154889 E050 4.2520945 0.3607094671 3.038853e-01 0.702977797 18 11902749 11902779 31 - 0.635 0.742 0.448
ENSG00000154889 E051 4.1112814 0.1083118788 6.074941e-01 0.878623379 18 11902780 11902856 77 - 0.650 0.720 0.292
ENSG00000154889 E052 3.5695222 0.3205869196 3.809130e-01 0.760646315 18 11905182 11905279 98 - 0.587 0.674 0.375
ENSG00000154889 E053 4.8113950 0.1154726631 5.538198e-01 0.855373883 18 11905347 11905458 112 - 0.698 0.764 0.271
ENSG00000154889 E054 15.5116135 0.0170842829 6.686893e-01 0.903720147 18 11905738 11905825 88 - 1.165 1.219 0.190
ENSG00000154889 E055 12.6539952 0.0388634684 8.313468e-01 0.957306057 18 11905826 11905911 86 - 1.123 1.109 -0.048
ENSG00000154889 E056 10.0227281 0.0026537614 2.632582e-01 0.668238596 18 11905912 11905953 42 - 1.090 0.980 -0.403
ENSG00000154889 E057 2.6006771 0.1251066183 5.302456e-01 0.845111327 18 11905954 11906202 249 - 0.460 0.595 0.638
ENSG00000154889 E058 52.7341233 0.0006183762 2.130364e-05 0.005108835 18 11906203 11906309 107 - 1.825 1.630 -0.662
ENSG00000154889 E059 0.9964960 0.1991362754 7.403530e-01   18 11907896 11908200 305 - 0.248 0.313 0.456
ENSG00000154889 E060 55.5597741 0.0007397704 1.137776e-04 0.014482616 18 11908201 11908366 166 - 1.835 1.661 -0.588