ENSG00000153113

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309190 ENSG00000153113 HEK293_DMSO_6hA HEK293_OSMI2_6hA CAST protein_coding protein_coding 27.35168 8.574445 15.86847 2.767763 3.652377 0.887275 6.6331279 1.9241698 3.277946 0.90321332 0.9734121 0.7654720 0.22720000 0.2062000 0.20706667 0.0008666667 1.000000e+00 3.675726e-06 FALSE TRUE
ENST00000509903 ENSG00000153113 HEK293_DMSO_6hA HEK293_OSMI2_6hA CAST protein_coding protein_coding 27.35168 8.574445 15.86847 2.767763 3.652377 0.887275 6.2912470 1.0649319 2.730806 0.53478915 0.1861908 1.3503549 0.18802917 0.1276000 0.19126667 0.0636666667 7.425841e-01 3.675726e-06 FALSE TRUE
ENST00000510500 ENSG00000153113 HEK293_DMSO_6hA HEK293_OSMI2_6hA CAST protein_coding protein_coding 27.35168 8.574445 15.86847 2.767763 3.652377 0.887275 0.2242606 0.0000000 1.066997 0.00000000 0.5369594 6.7508709 0.01739167 0.0000000 0.08626667 0.0862666667 3.061145e-01 3.675726e-06 FALSE TRUE
ENST00000674984 ENSG00000153113 HEK293_DMSO_6hA HEK293_OSMI2_6hA CAST protein_coding protein_coding 27.35168 8.574445 15.86847 2.767763 3.652377 0.887275 0.9240961 0.6912635 0.000000 0.08501024 0.0000000 -6.1318847 0.04062917 0.1014667 0.00000000 -0.1014666667 3.675726e-06 3.675726e-06 FALSE TRUE
ENST00000675734 ENSG00000153113 HEK293_DMSO_6hA HEK293_OSMI2_6hA CAST protein_coding processed_transcript 27.35168 8.574445 15.86847 2.767763 3.652377 0.887275 3.8273831 1.5549296 1.884999 0.33721648 0.9483835 0.2760994 0.14309583 0.1951000 0.09690000 -0.0982000000 7.006809e-01 3.675726e-06 FALSE TRUE
MSTRG.26659.28 ENSG00000153113 HEK293_DMSO_6hA HEK293_OSMI2_6hA CAST protein_coding   27.35168 8.574445 15.86847 2.767763 3.652377 0.887275 1.7332209 0.8858165 2.040582 0.44481455 1.0430475 1.1947582 0.08639583 0.1091000 0.10510000 -0.0040000000 1.000000e+00 3.675726e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000153113 E001 0.0000000       5 96525267 96525427 161 +      
ENSG00000153113 E002 0.0000000       5 96529821 96529880 60 +      
ENSG00000153113 E003 0.0000000       5 96545216 96545320 105 +      
ENSG00000153113 E004 0.0000000       5 96546228 96546518 291 +      
ENSG00000153113 E005 0.3529782 0.0394516813 0.68329705   5 96662055 96662072 18 + 0.094 0.151 0.789
ENSG00000153113 E006 0.3529782 0.0394516813 0.68329705   5 96662073 96662073 1 + 0.094 0.151 0.789
ENSG00000153113 E007 0.4654948 0.0214721249 0.96574693   5 96662074 96662125 52 + 0.171 0.151 -0.207
ENSG00000153113 E008 0.2937266 0.0274424043 0.41093886   5 96662126 96662165 40 + 0.171 0.000 -13.638
ENSG00000153113 E009 0.1125166 0.0320289111 0.80660057   5 96662203 96662236 34 + 0.093 0.000 -12.647
ENSG00000153113 E010 0.8527933 0.0157353588 0.88145178   5 96662237 96662329 93 + 0.292 0.263 -0.203
ENSG00000153113 E011 0.8544305 0.0153787590 0.29582012   5 96662330 96662351 22 + 0.343 0.151 -1.527
ENSG00000153113 E012 2.0169419 0.0096345854 0.30228173 0.70160281 5 96662352 96662375 24 + 0.533 0.352 -0.946
ENSG00000153113 E013 2.0856354 0.0139004166 0.30150974 0.70108577 5 96662376 96662402 27 + 0.534 0.352 -0.950
ENSG00000153113 E014 2.3106686 0.0087921806 0.17019552 0.56729215 5 96662403 96662422 20 + 0.590 0.352 -1.209
ENSG00000153113 E015 2.3012267 0.0082242571 0.42531495 0.78947179 5 96662423 96662427 5 + 0.562 0.426 -0.667
ENSG00000153113 E016 3.5869225 0.0061434081 0.87508836 0.96989531 5 96662428 96662474 47 + 0.664 0.637 -0.114
ENSG00000153113 E017 3.4666013 0.0072767571 0.99589769 0.99887162 5 96662475 96662497 23 + 0.641 0.637 -0.015
ENSG00000153113 E018 0.1812101 0.0378119787 0.80380860   5 96663000 96663003 4 + 0.094 0.000 -12.623
ENSG00000153113 E019 0.2937266 0.0274424043 0.41093886   5 96663004 96663020 17 + 0.171 0.000 -13.638
ENSG00000153113 E020 0.4704972 0.0217681645 0.21627774   5 96663021 96663024 4 + 0.236 0.000 -14.220
ENSG00000153113 E021 0.4704972 0.0217681645 0.21627774   5 96663025 96663030 6 + 0.236 0.000 -14.220
ENSG00000153113 E022 1.8279272 0.0098911896 0.39800048 0.77199643 5 96663031 96663166 136 + 0.501 0.352 -0.793
ENSG00000153113 E023 8.9465456 0.0029757109 0.75935623 0.93565945 5 96675539 96675601 63 + 1.006 0.970 -0.133
ENSG00000153113 E024 0.0000000       5 96675602 96675953 352 +      
ENSG00000153113 E025 0.5108041 0.0229762444 0.30265151   5 96679317 96679632 316 + 0.094 0.263 1.790
ENSG00000153113 E026 0.0000000       5 96695785 96695835 51 +      
ENSG00000153113 E027 9.1255164 0.0029919557 0.33959579 0.73158002 5 96695836 96695876 41 + 1.036 0.930 -0.396
ENSG00000153113 E028 9.7330157 0.0069812627 0.63939751 0.89204073 5 96695877 96695907 31 + 1.037 0.989 -0.177
ENSG00000153113 E029 0.0000000       5 96695908 96696294 387 +      
ENSG00000153113 E030 1.1084497 0.0137573382 0.06566714   5 96702781 96702787 7 + 0.171 0.489 2.114
ENSG00000153113 E031 1.1958541 0.0147957788 0.14783581   5 96702788 96702788 1 + 0.236 0.489 1.530
ENSG00000153113 E032 2.4548907 0.0130038151 0.69450893 0.91335383 5 96702789 96702798 10 + 0.531 0.593 0.283
ENSG00000153113 E033 2.3004300 0.0103518752 0.92534832 0.98227119 5 96702799 96702799 1 + 0.531 0.544 0.060
ENSG00000153113 E034 2.3004300 0.0103518752 0.92534832 0.98227119 5 96702800 96702800 1 + 0.531 0.544 0.060
ENSG00000153113 E035 2.3004300 0.0103518752 0.92534832 0.98227119 5 96702801 96702801 1 + 0.531 0.544 0.060
ENSG00000153113 E036 2.3004300 0.0103518752 0.92534832 0.98227119 5 96702802 96702802 1 + 0.531 0.544 0.060
ENSG00000153113 E037 2.9049570 0.1037346923 0.95702320 0.99014078 5 96702803 96702805 3 + 0.623 0.590 -0.145
ENSG00000153113 E038 7.5471948 0.1273945469 0.61904164 0.88358833 5 96702806 96702825 20 + 1.003 0.831 -0.648
ENSG00000153113 E039 11.2955826 0.0779442363 0.48842002 0.82368638 5 96702826 96702842 17 + 1.143 1.019 -0.452
ENSG00000153113 E040 16.4147440 0.0415523070 0.39460107 0.76971829 5 96702843 96702856 14 + 1.289 1.176 -0.399
ENSG00000153113 E041 30.0870526 0.0184212219 0.44765128 0.80230858 5 96702857 96702915 59 + 1.524 1.452 -0.248
ENSG00000153113 E042 0.0000000       5 96703188 96703221 34 +      
ENSG00000153113 E043 0.0000000       5 96703222 96703372 151 +      
ENSG00000153113 E044 0.0000000       5 96703373 96703424 52 +      
ENSG00000153113 E045 0.3356707 0.0263332335 0.68839693   5 96712349 96712473 125 + 0.094 0.151 0.789
ENSG00000153113 E046 0.9250030 0.0190987226 0.02663964   5 96714641 96715108 468 + 0.428 0.000 -15.345
ENSG00000153113 E047 49.1499923 0.0060473073 0.38596047 0.76447042 5 96722639 96722698 60 + 1.726 1.669 -0.192
ENSG00000153113 E048 0.6026480 0.0198470611 0.59338595   5 96722699 96722718 20 + 0.171 0.263 0.791
ENSG00000153113 E049 0.2250332 0.0532455750 0.42642660   5 96726754 96726793 40 + 0.169 0.000 -13.509
ENSG00000153113 E050 2.3097818 0.0081518206 0.19342230 0.59567583 5 96726794 96726859 66 + 0.429 0.637 0.986
ENSG00000153113 E051 45.3632349 0.0022435882 0.69968052 0.91495761 5 96727489 96727530 42 + 1.680 1.658 -0.074
ENSG00000153113 E052 0.0000000       5 96728309 96728418 110 +      
ENSG00000153113 E053 0.3262289 0.0274424043 0.09305438   5 96728588 96729152 565 + 0.000 0.263 13.964
ENSG00000153113 E054 43.5966135 0.0006970638 0.14188994 0.52784545 5 96729153 96729209 57 + 1.680 1.600 -0.274
ENSG00000153113 E055 0.5168808 0.1929102538 0.95313863   5 96729590 96729611 22 + 0.174 0.151 -0.252
ENSG00000153113 E056 68.4818971 0.0069252144 0.18988552 0.59128670 5 96729612 96729725 114 + 1.866 1.795 -0.237
ENSG00000153113 E057 50.4112817 0.0007213303 0.11119122 0.47765097 5 96730780 96730860 81 + 1.741 1.659 -0.278
ENSG00000153113 E058 26.0260933 0.0010701383 0.89934912 0.97594259 5 96736172 96736175 4 + 1.439 1.429 -0.033
ENSG00000153113 E059 48.9980792 0.0006589159 0.40143128 0.77429843 5 96736176 96736240 65 + 1.710 1.667 -0.147
ENSG00000153113 E060 60.0046170 0.0028032326 0.97488597 0.99413251 5 96737849 96737947 99 + 1.778 1.776 -0.008
ENSG00000153113 E061 48.7498064 0.0005598526 0.40976999 0.78022308 5 96740038 96740118 81 + 1.678 1.718 0.136
ENSG00000153113 E062 29.0518939 0.0010228909 0.67450546 0.90577084 5 96740745 96740783 39 + 1.465 1.492 0.092
ENSG00000153113 E063 46.8102442 0.0024321304 0.84679179 0.96209623 5 96741266 96741324 59 + 1.687 1.678 -0.032
ENSG00000153113 E064 34.6246737 0.0009157463 0.96551912 0.99207068 5 96741325 96741341 17 + 1.555 1.551 -0.012
ENSG00000153113 E065 30.6467087 0.0026663197 0.77498105 0.94090189 5 96741342 96741358 17 + 1.497 1.514 0.056
ENSG00000153113 E066 44.1792839 0.0236213765 0.90242361 0.97689052 5 96741494 96741580 87 + 1.666 1.631 -0.119
ENSG00000153113 E067 0.1767706 0.1181160902 0.80295103   5 96741581 96741873 293 + 0.094 0.000 -12.297
ENSG00000153113 E068 0.3435364 0.6103136515 0.20387936   5 96741874 96742156 283 + 0.000 0.265 12.716
ENSG00000153113 E069 0.3435364 0.6103136515 0.20387936   5 96742157 96742194 38 + 0.000 0.265 12.716
ENSG00000153113 E070 0.1717682 0.0515112960 0.28834754   5 96742195 96742220 26 + 0.000 0.151 12.824
ENSG00000153113 E071 0.1717682 0.0515112960 0.28834754   5 96742221 96742478 258 + 0.000 0.151 12.824
ENSG00000153113 E072 0.5203070 0.5082689501 0.46893412   5 96742479 96742654 176 + 0.096 0.265 1.759
ENSG00000153113 E073 54.2424038 0.0054319712 0.52974077 0.84478494 5 96742655 96742756 102 + 1.762 1.714 -0.164
ENSG00000153113 E074 0.0000000       5 96743540 96743568 29 +      
ENSG00000153113 E075 0.0000000       5 96743569 96743626 58 +      
ENSG00000153113 E076 0.0000000       5 96743627 96743672 46 +      
ENSG00000153113 E077 0.0000000       5 96743673 96743746 74 +      
ENSG00000153113 E078 60.1570565 0.0004740813 0.54364089 0.85159699 5 96746342 96746425 84 + 1.800 1.770 -0.099
ENSG00000153113 E079 47.8788169 0.0005981678 0.26803409 0.67250603 5 96747345 96747392 48 + 1.714 1.655 -0.199
ENSG00000153113 E080 0.0000000       5 96747393 96747399 7 +      
ENSG00000153113 E081 59.8306316 0.0005607947 0.90759414 0.97808717 5 96748518 96748613 96 + 1.783 1.777 -0.022
ENSG00000153113 E082 0.0000000       5 96748614 96748717 104 +      
ENSG00000153113 E083 31.8577111 0.0477518646 0.50900028 0.83418770 5 96750587 96750600 14 + 1.472 1.551 0.273
ENSG00000153113 E084 44.6855993 0.0074221887 0.81990599 0.95450926 5 96750601 96750654 54 + 1.646 1.658 0.041
ENSG00000153113 E085 48.4809363 0.0008229072 0.43474893 0.79430428 5 96750655 96750682 28 + 1.706 1.663 -0.145
ENSG00000153113 E086 0.0000000       5 96752052 96752119 68 +      
ENSG00000153113 E087 70.3179088 0.0006608005 0.73207471 0.92640164 5 96754060 96754161 102 + 1.844 1.857 0.043
ENSG00000153113 E088 68.2044166 0.0005606194 0.91113282 0.97871640 5 96754658 96754741 84 + 1.836 1.839 0.008
ENSG00000153113 E089 0.4214379 0.0265151511 0.30407210   5 96754742 96755196 455 + 0.094 0.263 1.794
ENSG00000153113 E090 0.5735719 0.0222475237 0.64562245   5 96757178 96757336 159 + 0.236 0.151 -0.789
ENSG00000153113 E091 50.9477565 0.0005885558 0.21560647 0.62025508 5 96757444 96757494 51 + 1.689 1.748 0.201
ENSG00000153113 E092 30.4666046 0.0010360339 0.66227522 0.90135806 5 96757583 96757585 3 + 1.482 1.509 0.091
ENSG00000153113 E093 54.9674876 0.0050514413 0.82175964 0.95499691 5 96757586 96757654 69 + 1.740 1.751 0.036
ENSG00000153113 E094 87.0746172 0.0004538068 0.62459502 0.88583324 5 96762274 96762372 99 + 1.952 1.931 -0.071
ENSG00000153113 E095 48.5180719 0.0010407455 0.86221429 0.96642877 5 96765221 96765223 3 + 1.691 1.697 0.021
ENSG00000153113 E096 106.8917975 0.0035935536 0.56685371 0.86082864 5 96765224 96765325 102 + 2.039 2.014 -0.083
ENSG00000153113 E097 100.4915214 0.0020038138 0.28265836 0.68558548 5 96766053 96766145 93 + 2.016 1.974 -0.142
ENSG00000153113 E098 76.6300450 0.0004114365 0.30892953 0.70722393 5 96767438 96767482 45 + 1.904 1.862 -0.143
ENSG00000153113 E099 101.1090500 0.0003914088 0.64274969 0.89347142 5 96767907 96767999 93 + 2.000 2.015 0.052
ENSG00000153113 E100 6.8073404 0.1924220844 0.10006724 0.45754927 5 96768948 96770530 1583 + 0.706 1.056 1.345
ENSG00000153113 E101 87.7683291 0.0006527520 0.19184202 0.59392261 5 96770531 96770602 72 + 1.927 1.976 0.168
ENSG00000153113 E102 79.8080250 0.0003941449 0.18259863 0.58257255 5 96771644 96771702 59 + 1.885 1.937 0.173
ENSG00000153113 E103 3.5770634 0.4072329775 0.21335368 0.61793661 5 96771703 96772639 937 + 0.478 0.829 1.515
ENSG00000153113 E104 101.5599349 0.0028020983 0.42790003 0.79082427 5 96772640 96772887 248 + 1.994 2.026 0.107
ENSG00000153113 E105 78.3435548 0.0032028941 0.51008710 0.83482123 5 96772888 96773267 380 + 1.885 1.916 0.106
ENSG00000153113 E106 28.3786756 0.0166589128 0.37008654 0.75352228 5 96773268 96773346 79 + 1.430 1.526 0.328
ENSG00000153113 E107 168.9767900 0.0002659835 0.00178995 0.07520559 5 96773347 96774683 1337 + 2.198 2.281 0.276
ENSG00000153113 E108 1.6729009 0.3277055647 0.41802890 0.78524481 5 96776868 96776954 87 + 0.307 0.539 1.260
ENSG00000153113 E109 0.0000000       5 96776955 96776987 33 +      
ENSG00000153113 E110 1.8753466 0.7535775665 0.48388431 0.82144119 5 96779322 96779640 319 + 0.418 0.484 0.341
ENSG00000153113 E111 0.4806895 0.0217681645 0.02996556   5 96781559 96781590 32 + 0.000 0.352 14.568