ENSG00000152795

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000507721 ENSG00000152795 HEK293_DMSO_6hA HEK293_OSMI2_6hA HNRNPDL protein_coding protein_coding 179.5313 98.46731 122.6582 24.2338 16.83461 0.3168981 45.92117 45.706154 25.137378 14.0972770 5.688769 -0.8622961 0.27009583 0.4524333 0.22606667 -0.22636667 0.0949330505 0.0001057252 FALSE TRUE
ENST00000621267 ENSG00000152795 HEK293_DMSO_6hA HEK293_OSMI2_6hA HNRNPDL protein_coding protein_coding 179.5313 98.46731 122.6582 24.2338 16.83461 0.3168981 13.66752 7.618143 6.386693 2.3520248 1.601059 -0.2540057 0.07516667 0.0754000 0.05073333 -0.02466667 0.3584256064 0.0001057252 FALSE TRUE
ENST00000630114 ENSG00000152795 HEK293_DMSO_6hA HEK293_OSMI2_6hA HNRNPDL protein_coding nonsense_mediated_decay 179.5313 98.46731 122.6582 24.2338 16.83461 0.3168981 17.86030 9.635299 12.987835 0.4860984 6.590492 0.4303735 0.10331667 0.1067000 0.09413333 -0.01256667 0.8868745229 0.0001057252 TRUE TRUE
ENST00000630827 ENSG00000152795 HEK293_DMSO_6hA HEK293_OSMI2_6hA HNRNPDL protein_coding protein_coding 179.5313 98.46731 122.6582 24.2338 16.83461 0.3168981 87.14428 27.871306 62.959444 6.8443006 12.914098 1.1753538 0.47061667 0.2830000 0.50273333 0.21973333 0.0001057252 0.0001057252 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000152795 E001 0.00000       4 82422565 82422568 4 -      
ENSG00000152795 E002 626.36471 0.0056671111 3.104370e-01 7.084825e-01 4 82422569 82424624 2056 - 2.753 2.840 0.289
ENSG00000152795 E003 56.74590 0.0249603584 6.385640e-01 8.916737e-01 4 82424625 82424628 4 - 1.718 1.798 0.269
ENSG00000152795 E004 55.16513 0.0268709701 8.093708e-01 9.513187e-01 4 82424629 82424629 1 - 1.716 1.776 0.203
ENSG00000152795 E005 55.26749 0.0285912166 6.569278e-01 8.994615e-01 4 82424630 82424630 1 - 1.707 1.786 0.270
ENSG00000152795 E006 1014.78910 0.0050602154 5.877971e-01 8.703248e-01 4 82424631 82424883 253 - 2.976 3.037 0.204
ENSG00000152795 E007 874.17884 0.0481922612 2.267836e-03 8.485027e-02 4 82424884 82425562 679 - 2.744 3.081 1.121
ENSG00000152795 E008 270.58350 0.0235147857 1.183889e-02 1.880356e-01 4 82425563 82425582 20 - 2.302 2.537 0.784
ENSG00000152795 E009 439.95501 0.0223272621 2.733138e-02 2.683731e-01 4 82425583 82425667 85 - 2.533 2.735 0.676
ENSG00000152795 E010 501.33745 0.0741032133 2.090653e-02 2.399756e-01 4 82425668 82426036 369 - 2.528 2.827 0.997
ENSG00000152795 E011 1115.04528 0.0017936603 3.052591e-01 7.041817e-01 4 82426037 82426129 93 - 3.037 3.061 0.081
ENSG00000152795 E012 1349.71633 0.0014788247 5.838828e-02 3.674900e-01 4 82426463 82426633 171 - 3.128 3.137 0.030
ENSG00000152795 E013 978.61903 0.0042082825 1.378545e-01 5.220848e-01 4 82427190 82427304 115 - 2.995 2.991 -0.013
ENSG00000152795 E014 1114.95252 0.0023671446 3.516653e-02 2.978726e-01 4 82427433 82427564 132 - 3.051 3.047 -0.014
ENSG00000152795 E015 1234.79874 0.0024972730 7.880938e-04 4.712103e-02 4 82428018 82428179 162 - 3.110 3.075 -0.116
ENSG00000152795 E016 1265.22393 0.0007875092 6.892099e-09 1.297821e-05 4 82428278 82428446 169 - 3.125 3.083 -0.138
ENSG00000152795 E017 833.13859 0.0013872512 4.470860e-07 3.179664e-04 4 82429248 82429412 165 - 2.952 2.893 -0.198
ENSG00000152795 E018 393.21717 0.0072255307 4.066669e-02 3.164256e-01 4 82429413 82430341 929 - 2.623 2.570 -0.176
ENSG00000152795 E019 13.19286 0.0456948481 5.610691e-01 8.584813e-01 4 82430342 82430568 227 - 1.180 1.123 -0.203