ENSG00000152127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409645 ENSG00000152127 HEK293_DMSO_6hA HEK293_OSMI2_6hA MGAT5 protein_coding protein_coding 15.77463 14.16487 15.39482 0.9352137 1.060905 0.1200463 12.251886 11.511186 13.9211950 0.8334963 1.00597371 0.2740298 0.7921458 0.8119667 0.9040 0.09203333 0.000523331 0.000523331 FALSE TRUE
MSTRG.19256.9 ENSG00000152127 HEK293_DMSO_6hA HEK293_OSMI2_6hA MGAT5 protein_coding   15.77463 14.16487 15.39482 0.9352137 1.060905 0.1200463 1.737858 2.052114 0.9875418 0.1062778 0.08681209 -1.0476750 0.1085708 0.1461333 0.0644 -0.08173333 0.025261415 0.000523331 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000152127 E001 2.287255 0.0104523042 0.622377954 0.88514985 2 134119942 134119944 3 + 0.454 0.558 0.503
ENSG00000152127 E002 4.138657 0.0054221352 0.669713272 0.90407019 2 134119945 134119962 18 + 0.725 0.692 -0.133
ENSG00000152127 E003 8.081509 0.0030924621 0.456081318 0.80671160 2 134119963 134119982 20 + 0.983 0.930 -0.195
ENSG00000152127 E004 9.023254 0.0030547594 0.652267907 0.89738427 2 134119983 134120163 181 + 1.009 0.992 -0.063
ENSG00000152127 E005 1.357664 0.1724179793 0.208835695   2 134120164 134120181 18 + 0.464 0.219 -1.544
ENSG00000152127 E006 10.106399 0.0023537269 0.413313912 0.78243315 2 134120182 134120291 110 + 1.059 1.007 -0.193
ENSG00000152127 E007 1.237996 0.4130619563 0.962920683   2 134190107 134190248 142 + 0.365 0.300 -0.406
ENSG00000152127 E008 0.000000       2 134250050 134250052 3 +      
ENSG00000152127 E009 2.272984 0.0106874265 0.435291577 0.79455518 2 134250053 134250145 93 + 0.405 0.558 0.763
ENSG00000152127 E010 3.393137 0.0113850651 0.698300080 0.91449256 2 134253095 134253103 9 + 0.578 0.662 0.371
ENSG00000152127 E011 12.046728 0.0022087978 0.467029234 0.81236283 2 134253104 134253218 115 + 1.048 1.148 0.364
ENSG00000152127 E012 0.000000       2 134254072 134254261 190 +      
ENSG00000152127 E013 8.517408 0.0040147246 0.157822969 0.55103978 2 134254262 134254264 3 + 1.023 0.896 -0.476
ENSG00000152127 E014 94.738264 0.0146597217 0.425781898 0.78963648 2 134254265 134254644 380 + 1.941 2.010 0.233
ENSG00000152127 E015 69.912251 0.0285296563 0.794240563 0.94622124 2 134270386 134270550 165 + 1.859 1.839 -0.067
ENSG00000152127 E016 52.269366 0.0035496403 0.994660026 0.99861307 2 134317529 134317605 77 + 1.705 1.735 0.101
ENSG00000152127 E017 53.040202 0.0005409881 0.551492570 0.85462189 2 134318650 134318739 90 + 1.722 1.727 0.017
ENSG00000152127 E018 48.486895 0.0006309249 0.506771686 0.83319856 2 134336217 134336288 72 + 1.685 1.685 0.000
ENSG00000152127 E019 72.451672 0.0320277612 0.730627981 0.92591642 2 134338259 134338420 162 + 1.871 1.855 -0.053
ENSG00000152127 E020 93.809622 0.0130369104 0.174921928 0.57276904 2 134341590 134341759 170 + 2.006 1.937 -0.232
ENSG00000152127 E021 84.606719 0.0015475456 0.146216699 0.53386434 2 134344930 134345064 135 + 1.934 1.904 -0.102
ENSG00000152127 E022 81.751462 0.0003671357 0.183307911 0.58345789 2 134349805 134349938 134 + 1.917 1.898 -0.062
ENSG00000152127 E023 94.582978 0.0003130077 0.343910765 0.73493662 2 134362275 134362408 134 + 1.970 1.969 -0.002
ENSG00000152127 E024 109.962480 0.0028538423 0.503432104 0.83149093 2 134402988 134403137 150 + 2.033 2.033 0.001
ENSG00000152127 E025 106.503135 0.0019468700 0.695707398 0.91363731 2 134412869 134413015 147 + 2.011 2.026 0.050
ENSG00000152127 E026 100.099494 0.0008630584 0.850265523 0.96311192 2 134422803 134422919 117 + 1.981 2.007 0.088
ENSG00000152127 E027 81.199350 0.0026527687 0.152210397 0.54229392 2 134428365 134428439 75 + 1.924 1.891 -0.110
ENSG00000152127 E028 107.604176 0.0004854773 0.002936529 0.09740941 2 134441758 134441915 158 + 2.063 1.993 -0.233
ENSG00000152127 E029 460.666551 0.0020427091 0.459800960 0.80843786 2 134448649 134449860 1212 + 2.653 2.664 0.035
ENSG00000152127 E030 2576.374098 0.0064996598 0.203174303 0.60697790 2 134449861 134454621 4761 + 3.386 3.433 0.156
ENSG00000152127 E031 0.000000       2 134494472 134494527 56 +