ENSG00000151725

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281453 ENSG00000151725 HEK293_DMSO_6hA HEK293_OSMI2_6hA CENPU protein_coding protein_coding 42.35204 17.15858 13.94889 5.040278 1.40395 -0.2985871 12.060312 4.036103 3.683392 1.331969 0.551003580 -0.1315868 0.2824958 0.2315333 0.2614667 0.02993333 0.749577751 0.002247794 FALSE TRUE
ENST00000502461 ENSG00000151725 HEK293_DMSO_6hA HEK293_OSMI2_6hA CENPU protein_coding retained_intron 42.35204 17.15858 13.94889 5.040278 1.40395 -0.2985871 3.321129 5.022539 1.977486 1.431042 0.002553741 -1.3403414 0.1111833 0.2951333 0.1447667 -0.15036667 0.002247794 0.002247794   FALSE
ENST00000510146 ENSG00000151725 HEK293_DMSO_6hA HEK293_OSMI2_6hA CENPU protein_coding nonsense_mediated_decay 42.35204 17.15858 13.94889 5.040278 1.40395 -0.2985871 22.988251 5.568604 7.357812 1.395491 1.038522388 0.4013322 0.5247375 0.3321667 0.5229333 0.19076667 0.003798605 0.002247794 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000151725 E001 29.3290225 0.0010095815 2.953880e-03 0.0976235392 4 184694085 184695001 917 - 1.365 1.559 0.669
ENSG00000151725 E002 51.6893241 0.0229320908 4.707094e-01 0.8141809869 4 184695002 184695128 127 - 1.691 1.741 0.171
ENSG00000151725 E003 174.2409638 0.0032326982 1.686796e-01 0.5655403890 4 184695129 184695348 220 - 2.216 2.264 0.159
ENSG00000151725 E004 110.1672764 0.0003157556 8.887518e-02 0.4361740712 4 184695349 184695401 53 - 2.017 2.075 0.193
ENSG00000151725 E005 165.2014559 0.0002554828 2.673784e-03 0.0927508449 4 184697647 184697803 157 - 2.178 2.259 0.272
ENSG00000151725 E006 29.9281007 0.0017206794 1.124008e-06 0.0006201025 4 184697804 184698096 293 - 1.276 1.607 1.143
ENSG00000151725 E007 15.6803868 0.0022004915 7.177486e-04 0.0450349893 4 184698194 184698318 125 - 1.025 1.329 1.084
ENSG00000151725 E008 93.6530663 0.0020182698 7.083040e-01 0.9180832629 4 184700820 184700881 62 - 1.970 1.991 0.070
ENSG00000151725 E009 10.3355102 0.0026542483 4.399266e-05 0.0082002023 4 184701905 184702088 184 - 0.751 1.201 1.684
ENSG00000151725 E010 75.2693357 0.0004561096 9.025774e-01 0.9768994977 4 184702089 184702136 48 - 1.888 1.886 -0.007
ENSG00000151725 E011 1.6193148 0.0137952586 7.288008e-02   4 184702137 184702362 226 - 0.220 0.535 1.879
ENSG00000151725 E012 92.6397475 0.0004566741 8.217228e-01 0.9549869765 4 184702363 184702441 79 - 1.980 1.974 -0.019
ENSG00000151725 E013 0.8246405 0.0613439107 7.147519e-01   4 184702442 184702481 40 - 0.220 0.282 0.470
ENSG00000151725 E014 90.8200421 0.0005361357 4.663200e-02 0.3348794243 4 184710072 184710147 76 - 2.003 1.934 -0.231
ENSG00000151725 E015 68.3411430 0.0005903175 1.059234e-01 0.4682149636 4 184710148 184710180 33 - 1.879 1.815 -0.215
ENSG00000151725 E016 0.1767706 0.0363877265 4.524542e-01   4 184710326 184710406 81 - 0.124 0.000 -9.864
ENSG00000151725 E017 91.0126940 0.0003644043 2.232242e-01 0.6279649491 4 184712944 184713013 70 - 1.992 1.951 -0.136
ENSG00000151725 E018 0.3485388 0.0258256040 9.494433e-01   4 184713869 184713941 73 - 0.124 0.115 -0.124
ENSG00000151725 E019 161.3775875 0.0003762234 8.440772e-02 0.4265796246 4 184716397 184716633 237 - 2.239 2.196 -0.144
ENSG00000151725 E020 78.3394074 0.0018202451 5.870585e-02 0.3683693643 4 184717136 184717196 61 - 1.946 1.871 -0.252
ENSG00000151725 E021 87.7652317 0.0003685037 7.210551e-03 0.1494806261 4 184724957 184725062 106 - 2.005 1.909 -0.320
ENSG00000151725 E022 73.3583027 0.0004311070 5.500295e-03 0.1321514190 4 184728918 184729035 118 - 1.934 1.825 -0.365
ENSG00000151725 E023 41.9531233 0.0032294466 1.333171e-01 0.5151332966 4 184730920 184730968 49 - 1.689 1.600 -0.303
ENSG00000151725 E024 0.1125166 0.0323211242 4.551936e-01   4 184733298 184733414 117 - 0.124 0.000 -9.856
ENSG00000151725 E025 28.2210662 0.0014107161 1.896919e-02 0.2307099634 4 184734016 184734130 115 - 1.552 1.403 -0.512