ENSG00000151502

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281187 ENSG00000151502 HEK293_DMSO_6hA HEK293_OSMI2_6hA VPS26B protein_coding protein_coding 44.04779 43.83206 62.14106 2.357665 6.75858 0.5034636 16.105219 13.694308 26.345944 1.4275547 3.1997023 0.9434989 0.3757917 0.3114333 0.42263333 0.111200000 0.03275683 0.03275683 FALSE TRUE
ENST00000531741 ENSG00000151502 HEK293_DMSO_6hA HEK293_OSMI2_6hA VPS26B protein_coding retained_intron 44.04779 43.83206 62.14106 2.357665 6.75858 0.5034636 2.321400 4.099862 2.723296 0.1362741 0.4706456 -0.5884482 0.0565000 0.0939000 0.04666667 -0.047233333 0.21038652 0.03275683   FALSE
MSTRG.6595.3 ENSG00000151502 HEK293_DMSO_6hA HEK293_OSMI2_6hA VPS26B protein_coding   44.04779 43.83206 62.14106 2.357665 6.75858 0.5034636 7.233443 6.127775 7.205456 0.7142385 1.6193851 0.2333747 0.1679667 0.1403000 0.11276667 -0.027533333 0.73448965 0.03275683 FALSE FALSE
MSTRG.6595.5 ENSG00000151502 HEK293_DMSO_6hA HEK293_OSMI2_6hA VPS26B protein_coding   44.04779 43.83206 62.14106 2.357665 6.75858 0.5034636 13.177095 14.196988 20.801125 1.4785585 3.3766467 0.5507543 0.2697583 0.3221333 0.33050000 0.008366667 0.94581714 0.03275683 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000151502 E001 7.437503 0.0035887048 8.310002e-03 0.159087949 11 134224671 134224676 6 + 1.026 0.711 -1.213
ENSG00000151502 E002 29.177873 0.0139527137 5.827209e-02 0.367142276 11 134224677 134224761 85 + 1.535 1.388 -0.508
ENSG00000151502 E003 31.108215 0.0049591711 1.008483e-02 0.174168547 11 134224762 134224799 38 + 1.571 1.400 -0.585
ENSG00000151502 E004 199.414613 0.0002145085 4.311884e-05 0.008082783 11 134224800 134225193 394 + 2.331 2.240 -0.306
ENSG00000151502 E005 253.183422 0.0001370518 5.068452e-03 0.127697683 11 134225194 134225298 105 + 2.417 2.368 -0.165
ENSG00000151502 E006 209.003539 0.0002044869 5.635589e-04 0.038749703 11 134225299 134225345 47 + 2.347 2.274 -0.243
ENSG00000151502 E007 220.775912 0.0001938332 4.576587e-01 0.807398871 11 134234897 134234961 65 + 2.341 2.336 -0.016
ENSG00000151502 E008 282.674505 0.0016078561 2.983354e-01 0.698579653 11 134234962 134235053 92 + 2.455 2.437 -0.060
ENSG00000151502 E009 16.460762 0.0259234657 1.764172e-01 0.574772459 11 134235054 134235707 654 + 1.155 1.314 0.564
ENSG00000151502 E010 22.357280 0.0840509419 1.548518e-01 0.546290223 11 134236342 134236746 405 + 1.258 1.465 0.721
ENSG00000151502 E011 20.926667 0.0534789021 1.559907e-02 0.212641881 11 134239651 134239990 340 + 1.168 1.479 1.084
ENSG00000151502 E012 388.337008 0.0006957528 9.196279e-01 0.980758017 11 134239991 134240155 165 + 2.575 2.590 0.051
ENSG00000151502 E013 15.672718 0.0103953615 8.209330e-02 0.422144278 11 134240465 134240621 157 + 1.132 1.306 0.616
ENSG00000151502 E014 457.895700 0.0001251889 8.740102e-01 0.969523929 11 134243119 134243294 176 + 2.646 2.662 0.053
ENSG00000151502 E015 42.781569 0.1021863941 4.720666e-02 0.336584852 11 134243427 134243733 307 + 1.492 1.768 0.940
ENSG00000151502 E016 129.728412 0.0530842590 1.542505e-03 0.069326523 11 134243852 134244937 1086 + 1.924 2.272 1.165
ENSG00000151502 E017 394.970728 0.0009978392 4.242975e-01 0.788894640 11 134244938 134245080 143 + 2.592 2.589 -0.010
ENSG00000151502 E018 2834.338422 0.0002075471 5.102189e-01 0.834856110 11 134245444 134247788 2345 + 3.439 3.455 0.056