ENSG00000150401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460318 ENSG00000150401 HEK293_DMSO_6hA HEK293_OSMI2_6hA DCUN1D2 protein_coding processed_transcript 5.810123 6.336313 3.765864 1.284318 0.5547932 -0.7491119 0.04708465 0.00000000 0.3117750 0.00000000 0.14180918 5.0079804 0.01216667 0.00000000 0.08906667 0.089066667 0.004894773 0.004894773 FALSE TRUE
ENST00000465710 ENSG00000150401 HEK293_DMSO_6hA HEK293_OSMI2_6hA DCUN1D2 protein_coding protein_coding 5.810123 6.336313 3.765864 1.284318 0.5547932 -0.7491119 0.43306122 0.73536065 0.2756238 0.20439343 0.22934817 -1.3838225 0.06934583 0.11283333 0.06093333 -0.051900000 0.662069003 0.004894773   FALSE
ENST00000465938 ENSG00000150401 HEK293_DMSO_6hA HEK293_OSMI2_6hA DCUN1D2 protein_coding protein_coding 5.810123 6.336313 3.765864 1.284318 0.5547932 -0.7491119 1.40811501 1.59987548 0.2559456 0.56437026 0.25594562 -2.5977459 0.19894583 0.23833333 0.05283333 -0.185500000 0.314435577 0.004894773 FALSE FALSE
ENST00000478244 ENSG00000150401 HEK293_DMSO_6hA HEK293_OSMI2_6hA DCUN1D2 protein_coding protein_coding 5.810123 6.336313 3.765864 1.284318 0.5547932 -0.7491119 0.76526470 0.56702467 0.5213739 0.10389390 0.39006034 -0.1189056 0.14454583 0.09496667 0.14340000 0.048433333 0.906237354 0.004894773 FALSE TRUE
MSTRG.9103.1 ENSG00000150401 HEK293_DMSO_6hA HEK293_OSMI2_6hA DCUN1D2 protein_coding   5.810123 6.336313 3.765864 1.284318 0.5547932 -0.7491119 2.31040836 2.73491382 1.6083810 0.39436630 0.45925264 -0.7622096 0.41969167 0.44083333 0.43390000 -0.006933333 0.993452964 0.004894773 TRUE TRUE
MSTRG.9103.5 ENSG00000150401 HEK293_DMSO_6hA HEK293_OSMI2_6hA DCUN1D2 protein_coding   5.810123 6.336313 3.765864 1.284318 0.5547932 -0.7491119 0.27727854 0.08842207 0.4477126 0.08842207 0.08925071 2.2173884 0.05346667 0.01646667 0.12833333 0.111866667 0.239004282 0.004894773 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000150401 E001 1.3874545 0.0586317848 0.9425364064   13 113455815 113455818 4 - 0.348 0.351 0.017
ENSG00000150401 E002 169.2515815 0.0123838493 0.9796609051 0.99512867 13 113455819 113457796 1978 - 2.218 2.206 -0.039
ENSG00000150401 E003 11.2161192 0.0081722093 0.8596488908 0.96560633 13 113457797 113457798 2 - 1.061 1.077 0.057
ENSG00000150401 E004 45.9362899 0.0006094268 0.9526249366 0.98898065 13 113457799 113458108 310 - 1.647 1.650 0.010
ENSG00000150401 E005 28.6350001 0.0013017766 0.5227851843 0.84147490 13 113459312 113459408 97 - 1.424 1.466 0.147
ENSG00000150401 E006 0.6199555 0.0193874923 0.6254042090   13 113459409 113459543 135 - 0.258 0.175 -0.706
ENSG00000150401 E007 12.7025917 0.0022807403 0.3563362792 0.74429121 13 113461054 113461054 1 - 1.170 1.085 -0.304
ENSG00000150401 E008 27.5002217 0.0064925348 0.6879394162 0.91115896 13 113461055 113461136 82 - 1.412 1.446 0.118
ENSG00000150401 E009 22.9615998 0.0126391377 0.1499781866 0.53937223 13 113462740 113462891 152 - 1.277 1.398 0.420
ENSG00000150401 E010 3.0732016 0.0070722759 0.1590349684 0.55279772 13 113462892 113463088 197 - 0.419 0.651 1.098
ENSG00000150401 E011 23.8861734 0.0013573318 0.3899775877 0.76695423 13 113474124 113474196 73 - 1.328 1.390 0.217
ENSG00000150401 E012 15.0851387 0.0020083102 0.5125369367 0.83633522 13 113474197 113474209 13 - 1.215 1.158 -0.203
ENSG00000150401 E013 20.0131224 0.0013131843 0.6167422631 0.88276519 13 113474210 113474254 45 - 1.275 1.314 0.136
ENSG00000150401 E014 1.1641486 0.0250470154 0.0104255705   13 113480466 113480574 109 - 0.537 0.096 -3.302
ENSG00000150401 E015 28.6697052 0.0011645549 0.9383452219 0.98556781 13 113480575 113480647 73 - 1.449 1.455 0.020
ENSG00000150401 E016 22.9255767 0.0012513464 0.3281414510 0.72309434 13 113480648 113480743 96 - 1.403 1.334 -0.239
ENSG00000150401 E017 16.1841281 0.0017386544 0.8980249101 0.97566612 13 113483840 113483901 62 - 1.225 1.214 -0.038
ENSG00000150401 E018 20.6181859 0.0014293512 0.9093729900 0.97832956 13 113483902 113483962 61 - 1.310 1.319 0.030
ENSG00000150401 E019 20.9403403 0.0015854078 0.6249040893 0.88597223 13 113483963 113484056 94 - 1.302 1.339 0.131
ENSG00000150401 E020 17.8253499 0.0016664871 0.3115914854 0.70936849 13 113484057 113484196 140 - 1.302 1.221 -0.286
ENSG00000150401 E021 4.9167137 0.0056761358 0.7750107839 0.94091377 13 113489090 113489173 84 - 0.737 0.775 0.156
ENSG00000150401 E022 4.3580616 0.0053689266 0.7775359481 0.94159157 13 113489174 113489253 80 - 0.737 0.696 -0.167
ENSG00000150401 E023 1.5385500 0.0123437498 0.7763402539   13 113490433 113490666 234 - 0.346 0.396 0.290
ENSG00000150401 E024 2.7066294 0.0099451872 0.0002373248 0.02271916 13 113490667 113490951 285 - 0.825 0.242 -2.930