ENSG00000149930

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279394 ENSG00000149930 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAOK2 protein_coding protein_coding 62.8858 78.65321 91.95398 6.95776 5.141074 0.2253799 17.705507 18.456071 25.015409 1.9227797 2.752858 0.438516709 0.27507500 0.2339667 0.27143333 0.03746667 0.653035537 0.008475405 FALSE TRUE
ENST00000308893 ENSG00000149930 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAOK2 protein_coding protein_coding 62.8858 78.65321 91.95398 6.95776 5.141074 0.2253799 29.841475 32.790200 46.447165 2.5177328 3.484236 0.502196490 0.49318750 0.4178333 0.50420000 0.08636667 0.008475405 0.008475405 FALSE TRUE
ENST00000566552 ENSG00000149930 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAOK2 protein_coding retained_intron 62.8858 78.65321 91.95398 6.95776 5.141074 0.2253799 6.575891 9.800143 9.813066 1.8033567 1.401374 0.001899353 0.08254167 0.1225000 0.10620000 -0.01630000 0.753634926 0.008475405 FALSE TRUE
ENST00000570844 ENSG00000149930 HEK293_DMSO_6hA HEK293_OSMI2_6hA TAOK2 protein_coding retained_intron 62.8858 78.65321 91.95398 6.95776 5.141074 0.2253799 4.122003 10.366118 5.004764 0.7306288 2.639078 -1.049013064 0.06875417 0.1326667 0.05606667 -0.07660000 0.191117986 0.008475405 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000149930 E001 14.02602 1.794379e-03 8.090959e-01 9.511710e-01 16 29973868 29973882 15 + 1.178 1.168 -0.037
ENSG00000149930 E002 19.00928 1.426945e-03 6.530283e-01 8.977622e-01 16 29973883 29973886 4 + 1.314 1.290 -0.084
ENSG00000149930 E003 54.42486 4.370059e-03 8.272166e-02 4.234287e-01 16 29973887 29973898 12 + 1.786 1.697 -0.303
ENSG00000149930 E004 413.56313 8.873809e-04 6.455899e-03 1.417894e-01 16 29973899 29974181 283 + 2.641 2.590 -0.168
ENSG00000149930 E005 335.37297 9.083369e-04 2.594828e-03 9.131159e-02 16 29974182 29974280 99 + 2.555 2.494 -0.206
ENSG00000149930 E006 707.02426 4.380493e-04 1.602978e-04 1.777965e-02 16 29974281 29974648 368 + 2.872 2.822 -0.165
ENSG00000149930 E007 587.22041 1.638817e-04 3.182285e-03 1.015603e-01 16 29977738 29977904 167 + 2.784 2.751 -0.113
ENSG00000149930 E008 451.98358 1.265708e-04 2.599916e-02 2.622287e-01 16 29978089 29978160 72 + 2.664 2.638 -0.087
ENSG00000149930 E009 559.99861 1.691334e-04 8.810294e-03 1.636586e-01 16 29978252 29978353 102 + 2.758 2.729 -0.098
ENSG00000149930 E010 384.31059 8.621608e-04 1.961287e-02 2.338487e-01 16 29978799 29978844 46 + 2.600 2.561 -0.131
ENSG00000149930 E011 541.80985 4.592144e-04 3.570120e-04 2.931614e-02 16 29978974 29979070 97 + 2.754 2.703 -0.171
ENSG00000149930 E012 668.54456 3.766950e-04 4.287358e-02 3.232862e-01 16 29979195 29979308 114 + 2.831 2.811 -0.065
ENSG00000149930 E013 598.52129 1.294650e-04 6.158137e-02 3.757765e-01 16 29979417 29979508 92 + 2.782 2.766 -0.054
ENSG00000149930 E014 96.74021 1.731848e-01 2.040754e-02 2.378600e-01 16 29980352 29981660 1309 + 1.794 2.128 1.124
ENSG00000149930 E015 554.48110 9.334670e-05 4.885877e-02 3.410564e-01 16 29981661 29981754 94 + 2.751 2.733 -0.062
ENSG00000149930 E016 493.70409 1.439536e-04 2.229721e-02 2.469983e-01 16 29981859 29981940 82 + 2.705 2.679 -0.088
ENSG00000149930 E017 780.15326 8.494287e-05 1.737683e-01 5.713629e-01 16 29982734 29982901 168 + 2.892 2.886 -0.020
ENSG00000149930 E018 1014.48269 6.090631e-05 8.957249e-02 4.378317e-01 16 29983072 29983332 261 + 3.007 3.000 -0.025
ENSG00000149930 E019 813.84717 2.257475e-04 1.458261e-01 5.334136e-01 16 29983503 29983664 162 + 2.914 2.905 -0.029
ENSG00000149930 E020 30.74467 7.510523e-02 7.878538e-02 4.149724e-01 16 29985118 29985212 95 + 1.382 1.593 0.726
ENSG00000149930 E021 1331.65792 5.563386e-04 1.137139e-01 4.819622e-01 16 29985213 29985578 366 + 3.128 3.119 -0.030
ENSG00000149930 E022 726.50508 2.381249e-03 4.421838e-01 7.988687e-01 16 29985658 29985861 204 + 2.862 2.860 -0.007
ENSG00000149930 E023 889.17245 2.523330e-03 2.173885e-01 6.219775e-01 16 29986265 29986504 240 + 2.955 2.942 -0.044
ENSG00000149930 E024 1074.72618 1.524150e-04 1.859034e-01 5.866609e-01 16 29986505 29986843 339 + 3.014 3.042 0.094
ENSG00000149930 E025 2562.87784 2.410716e-04 4.259740e-01 7.897181e-01 16 29986844 29988358 1515 + 3.396 3.418 0.071
ENSG00000149930 E026 116.22860 1.712424e-02 1.211085e-03 6.033906e-02 16 29988359 29988450 92 + 1.938 2.170 0.776
ENSG00000149930 E027 110.64148 7.812131e-02 3.089856e-02 2.828666e-01 16 29989195 29989274 80 + 1.913 2.152 0.804
ENSG00000149930 E028 499.82021 1.145011e-03 4.148850e-04 3.227708e-02 16 29989593 29989805 213 + 2.649 2.741 0.306
ENSG00000149930 E029 212.51686 2.220068e-01 2.178099e-02 2.442756e-01 16 29989910 29990542 633 + 2.106 2.481 1.251
ENSG00000149930 E030 123.25864 8.835407e-02 9.735182e-03 1.714806e-01 16 29990543 29990647 105 + 1.909 2.227 1.065
ENSG00000149930 E031 103.98937 1.412702e-01 8.854954e-03 1.640225e-01 16 29990648 29990783 136 + 1.800 2.170 1.245
ENSG00000149930 E032 434.62076 1.056357e-04 9.995576e-04 5.411163e-02 16 29990784 29990966 183 + 2.599 2.668 0.228
ENSG00000149930 E033 1087.73328 2.508471e-04 5.915059e-08 6.534523e-05 16 29991047 29992261 1215 + 2.991 3.073 0.272