ENSG00000149743

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317459 ENSG00000149743 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRPT1 protein_coding protein_coding 31.42575 31.73189 46.84539 2.828843 7.80291 0.5618269 10.441967 10.362979 16.679805 0.9744310 2.7336211 0.6861369 0.31789167 0.32696667 0.35626667 0.029300000 7.469710e-01 1.149984e-21 FALSE TRUE
ENST00000394547 ENSG00000149743 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRPT1 protein_coding protein_coding 31.42575 31.73189 46.84539 2.828843 7.80291 0.5618269 2.277387 0.000000 5.157775 0.0000000 0.9222122 9.0133994 0.08150000 0.00000000 0.11620000 0.116200000 1.149984e-21 1.149984e-21 FALSE TRUE
ENST00000541928 ENSG00000149743 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRPT1 protein_coding retained_intron 31.42575 31.73189 46.84539 2.828843 7.80291 0.5618269 1.410615 2.696429 1.569857 0.3372635 0.3136551 -0.7765963 0.05591667 0.08436667 0.03456667 -0.049800000 2.434983e-02 1.149984e-21 TRUE FALSE
ENST00000546133 ENSG00000149743 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRPT1 protein_coding protein_coding 31.42575 31.73189 46.84539 2.828843 7.80291 0.5618269 1.822178 1.603770 2.642970 0.4045722 0.9239506 0.7171735 0.06250417 0.05170000 0.05303333 0.001333333 9.972886e-01 1.149984e-21 FALSE TRUE
MSTRG.5663.17 ENSG00000149743 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRPT1 protein_coding   31.42575 31.73189 46.84539 2.828843 7.80291 0.5618269 1.926140 3.359718 3.106508 0.5844843 2.3402897 -0.1126972 0.04947500 0.10420000 0.05396667 -0.050233333 7.412635e-01 1.149984e-21 FALSE TRUE
MSTRG.5663.21 ENSG00000149743 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRPT1 protein_coding   31.42575 31.73189 46.84539 2.828843 7.80291 0.5618269 4.442256 4.373747 7.346683 0.8748973 2.1800178 0.7468910 0.12384167 0.13496667 0.15026667 0.015300000 9.263915e-01 1.149984e-21   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000149743 E001 1.2683883 0.0123738697 0.706363165   11 64223226 64223431 206 - 0.320 0.394 0.437
ENSG00000149743 E002 1.1514323 0.0136491723 0.469799910   11 64223432 64223798 367 - 0.260 0.394 0.850
ENSG00000149743 E003 0.1544607 0.0437801123 0.384626284   11 64223799 64223799 1 - 0.000 0.136 10.613
ENSG00000149743 E004 0.1544607 0.0437801123 0.384626284   11 64223800 64223815 16 - 0.000 0.136 10.613
ENSG00000149743 E005 0.8682218 0.0563461061 0.485861929   11 64223816 64223829 14 - 0.190 0.323 1.009
ENSG00000149743 E006 1.5649172 0.0128188069 0.673888990   11 64223830 64223832 3 - 0.373 0.454 0.439
ENSG00000149743 E007 3.2937370 0.1791410828 0.765165485 0.93772808 11 64223833 64223841 9 - 0.596 0.673 0.333
ENSG00000149743 E008 3.6125758 0.2666519566 0.988865313 0.99722410 11 64223842 64223852 11 - 0.650 0.676 0.111
ENSG00000149743 E009 3.9689192 0.1695019845 0.947758479 0.98772912 11 64223853 64223855 3 - 0.679 0.709 0.123
ENSG00000149743 E010 5.8447195 0.1736671793 0.821954889 0.95500291 11 64223856 64223876 21 - 0.772 0.890 0.462
ENSG00000149743 E011 31.9171117 0.0070247340 0.932520182 0.98402269 11 64223877 64223887 11 - 1.519 1.525 0.021
ENSG00000149743 E012 160.5853788 0.0017988447 0.270032199 0.67436664 11 64223888 64223967 80 - 2.182 2.236 0.182
ENSG00000149743 E013 22.3432681 0.0228404462 0.002041032 0.08047045 11 64223968 64224099 132 - 1.175 1.513 1.176
ENSG00000149743 E014 176.6128356 0.0002000859 0.227262765 0.63228535 11 64224100 64224162 63 - 2.229 2.274 0.150
ENSG00000149743 E015 151.6900990 0.0002103077 0.228917865 0.63407626 11 64224163 64224202 40 - 2.161 2.209 0.159
ENSG00000149743 E016 112.4820247 0.0003428853 0.912242581 0.97904957 11 64224203 64224210 8 - 2.049 2.059 0.035
ENSG00000149743 E017 27.0710129 0.0525107923 0.068819362 0.39335343 11 64224211 64224213 3 - 1.329 1.562 0.803
ENSG00000149743 E018 27.8505136 0.0269210344 0.001114263 0.05759306 11 64224214 64224284 71 - 1.262 1.615 1.217
ENSG00000149743 E019 237.5046273 0.0007799695 0.088180912 0.43457777 11 64224285 64224341 57 - 2.390 2.363 -0.089
ENSG00000149743 E020 34.0570651 0.0235415812 0.014841465 0.20747743 11 64224342 64224491 150 - 1.426 1.657 0.791
ENSG00000149743 E021 18.3013291 0.0961603947 0.053982830 0.35578255 11 64224492 64224542 51 - 1.123 1.417 1.033
ENSG00000149743 E022 312.8867965 0.0001536058 0.005905077 0.13670360 11 64224543 64224653 111 - 2.515 2.476 -0.130
ENSG00000149743 E023 236.0155422 0.0008729368 0.222592981 0.62722181 11 64224654 64224717 64 - 2.384 2.367 -0.055
ENSG00000149743 E024 23.6235673 0.0814332770 0.014954279 0.20830720 11 64224759 64224794 36 - 1.188 1.545 1.240
ENSG00000149743 E025 19.7960666 0.0479016539 0.034591077 0.29603124 11 64224795 64224800 6 - 1.173 1.441 0.938
ENSG00000149743 E026 231.4983424 0.0002026229 0.101029504 0.45919890 11 64224801 64224970 170 - 2.377 2.354 -0.077
ENSG00000149743 E027 95.4929770 0.0628736935 0.109368812 0.47455869 11 64224971 64225498 528 - 1.888 2.072 0.619
ENSG00000149743 E028 204.6060153 0.0018095329 0.013521676 0.20015901 11 64225499 64225580 82 - 2.339 2.281 -0.194
ENSG00000149743 E029 138.5598952 0.0009994713 0.064827088 0.38392499 11 64225786 64225869 84 - 2.162 2.118 -0.147
ENSG00000149743 E030 28.9993142 0.0198951568 0.644926470 0.89434805 11 64225870 64226049 180 - 1.446 1.501 0.186
ENSG00000149743 E031 192.3753125 0.0002111726 0.000366063 0.02977285 11 64226050 64226190 141 - 2.319 2.244 -0.252
ENSG00000149743 E032 20.0520404 0.0013504842 0.553070050 0.85515619 11 64226191 64226254 64 - 1.336 1.305 -0.110