ENSG00000149503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278849 ENSG00000149503 HEK293_DMSO_6hA HEK293_OSMI2_6hA INCENP protein_coding protein_coding 36.87599 28.29405 42.1917 0.6254181 2.507566 0.5762924 22.06028 17.964862 28.035286 0.13451501 1.446403 0.6417776 0.6035917 0.6353667 0.6662333 0.03086667 0.74799700 0.02208118 FALSE TRUE
MSTRG.5589.5 ENSG00000149503 HEK293_DMSO_6hA HEK293_OSMI2_6hA INCENP protein_coding   36.87599 28.29405 42.1917 0.6254181 2.507566 0.5762924 6.36282 5.408734 1.426205 0.09543998 1.164424 -1.9156937 0.1727375 0.1912333 0.0371000 -0.15413333 0.16410279 0.02208118 FALSE TRUE
MSTRG.5589.6 ENSG00000149503 HEK293_DMSO_6hA HEK293_OSMI2_6hA INCENP protein_coding   36.87599 28.29405 42.1917 0.6254181 2.507566 0.5762924 4.31690 2.856702 11.167653 0.55164997 2.649352 1.9631535 0.1182042 0.1002667 0.2589333 0.15866667 0.02208118 0.02208118 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000149503 E001 0.1125166 3.276434e-02 0.6395522092   11 62123998 62124002 5 + 0.103 0.000 -8.754
ENSG00000149503 E002 0.4688600 2.116339e-02 0.7609307644   11 62124003 62124005 3 + 0.187 0.138 -0.525
ENSG00000149503 E003 0.6406282 1.938749e-02 0.7597036531   11 62124006 62124009 4 + 0.187 0.242 0.475
ENSG00000149503 E004 0.8123964 1.656682e-02 0.4338997471   11 62124010 62124010 1 + 0.187 0.327 1.060
ENSG00000149503 E005 93.7191950 3.022172e-04 0.3684493553 0.75251586 11 62124011 62124055 45 + 1.981 1.956 -0.085
ENSG00000149503 E006 254.3456113 2.302944e-03 0.4537673236 0.80550194 11 62124056 62124163 108 + 2.409 2.392 -0.058
ENSG00000149503 E007 362.8340806 2.228439e-04 0.2409407240 0.64601072 11 62128151 62128301 151 + 2.560 2.545 -0.049
ENSG00000149503 E008 282.2529178 1.280161e-04 0.4370017113 0.79581424 11 62128770 62128883 114 + 2.436 2.460 0.081
ENSG00000149503 E009 858.9879953 7.137157e-05 0.2700224387 0.67436664 11 62129782 62130558 777 + 2.931 2.926 -0.018
ENSG00000149503 E010 172.0693201 5.583483e-03 0.2849066801 0.68751421 11 62130559 62130590 32 + 2.249 2.212 -0.123
ENSG00000149503 E011 208.1443811 5.555480e-03 0.8882245722 0.97326506 11 62137832 62137883 52 + 2.316 2.317 0.003
ENSG00000149503 E012 2.4591500 8.492496e-03 0.0004479219 0.03369659 11 62137884 62137976 93 + 0.187 0.767 3.174
ENSG00000149503 E013 218.7384511 3.141030e-03 0.7349485674 0.92752096 11 62138713 62138770 58 + 2.331 2.349 0.060
ENSG00000149503 E014 328.7295177 1.310680e-04 0.8655340603 0.96713877 11 62138888 62139005 118 + 2.511 2.516 0.015
ENSG00000149503 E015 254.3294206 1.885206e-04 0.2913749494 0.69266075 11 62140234 62140285 52 + 2.411 2.395 -0.054
ENSG00000149503 E016 320.4604596 1.594640e-04 0.0440387528 0.32660400 11 62140704 62140821 118 + 2.517 2.484 -0.109
ENSG00000149503 E017 304.0423852 1.903357e-03 0.6962577176 0.91375801 11 62140913 62141044 132 + 2.481 2.480 -0.005
ENSG00000149503 E018 23.1927525 1.238595e-03 0.0942141062 0.44660942 11 62141500 62141511 12 + 1.424 1.310 -0.396
ENSG00000149503 E019 12.8282352 1.935731e-02 0.0787198029 0.41496765 11 62141512 62141745 234 + 1.032 1.232 0.716
ENSG00000149503 E020 313.0069344 4.542355e-04 0.8306750926 0.95698839 11 62144982 62145091 110 + 2.493 2.495 0.008
ENSG00000149503 E021 348.1131689 1.179869e-04 0.4158723021 0.78400209 11 62145169 62145289 121 + 2.541 2.533 -0.026
ENSG00000149503 E022 374.7888174 1.176966e-04 0.3012529694 0.70085259 11 62145629 62145751 123 + 2.558 2.585 0.089
ENSG00000149503 E023 56.9405468 1.261236e-03 0.5073889964 0.83343004 11 62145752 62145763 12 + 1.744 1.784 0.133
ENSG00000149503 E024 381.6612175 3.862040e-03 0.6643951199 0.90204711 11 62146658 62146902 245 + 2.584 2.577 -0.021
ENSG00000149503 E025 184.7099486 8.708732e-03 0.3628363492 0.74896296 11 62148476 62148554 79 + 2.281 2.248 -0.110
ENSG00000149503 E026 250.3947593 5.026741e-03 0.2532402761 0.65902684 11 62148739 62148846 108 + 2.412 2.379 -0.111
ENSG00000149503 E027 381.5274877 1.332446e-04 0.0292292900 0.27651606 11 62150057 62150207 151 + 2.592 2.560 -0.107
ENSG00000149503 E028 897.0440360 9.874578e-04 0.2799014938 0.68318418 11 62151762 62152481 720 + 2.937 2.962 0.085
ENSG00000149503 E029 149.8850766 1.105716e-02 0.1189827194 0.49167929 11 62152482 62152551 70 + 2.129 2.221 0.307
ENSG00000149503 E030 161.3828105 1.229309e-02 0.3087814012 0.70710949 11 62152552 62152672 121 + 2.176 2.238 0.206
ENSG00000149503 E031 463.3328579 1.172153e-02 0.0344847413 0.29568623 11 62152673 62153224 552 + 2.611 2.720 0.364