ENSG00000149273

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526608 ENSG00000149273 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPS3 protein_coding protein_coding 5099.758 4072.486 5957.42 481.0174 1360.822 0.5487766 2795.3906 2216.2449 3151.0897 224.00871 685.5805 0.5077316 0.5397125 0.54663333 0.5322000 -0.014433333 7.522825e-01 1.235394e-06 FALSE  
ENST00000527446 ENSG00000149273 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPS3 protein_coding protein_coding 5099.758 4072.486 5957.42 481.0174 1360.822 0.5487766 570.0913 294.7442 799.2796 28.26424 231.5401 1.4392060 0.1165792 0.07290000 0.1301667 0.057266667 1.235394e-06 1.235394e-06 FALSE  
ENST00000528847 ENSG00000149273 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPS3 protein_coding protein_coding 5099.758 4072.486 5957.42 481.0174 1360.822 0.5487766 1228.4581 1175.6949 1446.1107 190.73613 325.2539 0.2986619 0.2407667 0.28550000 0.2432000 -0.042300000 2.159061e-01 1.235394e-06    
ENST00000531188 ENSG00000149273 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPS3 protein_coding protein_coding 5099.758 4072.486 5957.42 481.0174 1360.822 0.5487766 464.9885 339.1224 526.2538 41.42000 127.4612 0.6339374 0.0931875 0.08316667 0.0875000 0.004333333 7.354412e-01 1.235394e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000149273 E001 75.996544 6.629368e-04 5.634936e-01 0.859437492 11 75399515 75399517 3 + 1.874 1.887 0.045
ENSG00000149273 E002 78.545211 8.956199e-04 3.583268e-01 0.745608847 11 75399518 75399518 1 + 1.882 1.910 0.093
ENSG00000149273 E003 96.927889 2.118181e-03 2.496732e-01 0.655266677 11 75399519 75399519 1 + 1.966 2.005 0.131
ENSG00000149273 E004 237.968802 1.121399e-03 4.913287e-01 0.825173372 11 75399520 75399529 10 + 2.384 2.356 -0.092
ENSG00000149273 E005 436.234606 8.774638e-03 2.336216e-03 0.086263819 11 75399530 75399530 1 + 2.705 2.541 -0.543
ENSG00000149273 E006 6640.894761 1.215674e-03 2.092562e-06 0.000999707 11 75399531 75399536 6 + 3.859 3.768 -0.306
ENSG00000149273 E007 12670.089023 2.319377e-03 7.215093e-04 0.045168333 11 75399537 75399541 5 + 4.141 4.047 -0.311
ENSG00000149273 E008 13117.454511 2.083288e-03 9.109579e-04 0.051184375 11 75399542 75399542 1 + 4.154 4.066 -0.291
ENSG00000149273 E009 18033.090810 1.326445e-03 2.740111e-03 0.093814250 11 75399543 75399556 14 + 4.283 4.218 -0.216
ENSG00000149273 E010 23309.407214 1.031289e-03 3.499692e-02 0.297430457 11 75399557 75399577 21 + 4.385 4.341 -0.145
ENSG00000149273 E011 6.346829 7.861985e-02 5.198308e-01 0.840027925 11 75399670 75399698 29 + 0.823 0.921 0.374
ENSG00000149273 E012 12.234737 3.986951e-02 4.647679e-01 0.811041863 11 75399699 75399840 142 + 1.078 1.165 0.313
ENSG00000149273 E013 6.199181 1.403467e-01 4.261225e-01 0.789847091 11 75399841 75399866 26 + 0.780 0.924 0.557
ENSG00000149273 E014 3.224171 3.416134e-02 2.265291e-01 0.631511104 11 75400391 75400403 13 + 0.507 0.703 0.870
ENSG00000149273 E015 14.791151 1.828814e-02 1.024181e-01 0.461811923 11 75400404 75400585 182 + 1.113 1.280 0.593
ENSG00000149273 E016 109.933581 2.921172e-04 8.196647e-01 0.954457104 11 75400692 75400693 2 + 2.038 2.035 -0.011
ENSG00000149273 E017 23429.825093 1.065319e-03 4.523246e-02 0.330616498 11 75400694 75400694 1 + 4.387 4.344 -0.141
ENSG00000149273 E018 37842.491519 3.846890e-04 9.510810e-01 0.988557010 11 75400695 75400777 83 + 4.580 4.571 -0.028
ENSG00000149273 E019 34629.257005 5.166006e-04 1.012359e-01 0.459572100 11 75400778 75400824 47 + 4.531 4.545 0.045
ENSG00000149273 E020 40658.357746 9.890332e-05 3.626895e-01 0.748921051 11 75401640 75401705 66 + 4.607 4.605 -0.006
ENSG00000149273 E021 27319.096608 3.861285e-04 1.731762e-01 0.570752155 11 75401706 75401725 20 + 4.431 4.439 0.027
ENSG00000149273 E022 21026.525062 8.758612e-04 3.998113e-01 0.773191843 11 75401726 75401733 8 + 4.317 4.326 0.030
ENSG00000149273 E023 67.230153 2.174825e-01 8.817648e-03 0.163715806 11 75401734 75402303 570 + 1.500 2.046 1.847
ENSG00000149273 E024 126.220974 1.842244e-03 5.865401e-03 0.136275286 11 75402304 75402351 48 + 2.051 2.149 0.328
ENSG00000149273 E025 23295.946660 4.598721e-04 6.322176e-01 0.888881011 11 75402352 75402379 28 + 4.364 4.366 0.005
ENSG00000149273 E026 29489.671561 2.958976e-04 1.429031e-01 0.529343378 11 75402380 75402446 67 + 4.463 4.472 0.029
ENSG00000149273 E027 227.423618 6.518603e-02 7.660062e-03 0.153907514 11 75402447 75403945 1499 + 2.173 2.506 1.111
ENSG00000149273 E028 25158.501609 3.952864e-04 3.034559e-02 0.280912768 11 75404020 75404053 34 + 4.390 4.408 0.061
ENSG00000149273 E029 34191.250169 3.621607e-04 2.899795e-02 0.275623566 11 75404054 75404148 95 + 4.524 4.541 0.056
ENSG00000149273 E030 21824.732826 4.624774e-04 3.946048e-01 0.769718292 11 75404149 75404207 59 + 4.334 4.341 0.024
ENSG00000149273 E031 25905.920219 7.837897e-04 1.381709e-01 0.522552401 11 75404672 75404759 88 + 4.402 4.422 0.066
ENSG00000149273 E032 23508.673977 7.097163e-04 1.973510e-02 0.234277820 11 75404760 75404868 109 + 4.356 4.384 0.094
ENSG00000149273 E033 324.967174 8.063348e-02 1.016634e-02 0.174782960 11 75404869 75405582 714 + 2.318 2.667 1.163
ENSG00000149273 E034 74.765520 1.798571e-02 3.570776e-04 0.029316144 11 75405583 75405613 31 + 1.729 2.000 0.913
ENSG00000149273 E035 9247.346025 4.712538e-04 1.960264e-02 0.233777161 11 75405614 75406907 1294 + 3.954 3.975 0.071
ENSG00000149273 E036 26.611167 1.332796e-03 7.741102e-05 0.011720793 11 75421727 75422280 554 + 1.298 1.556 0.889