ENSG00000149136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278412 ENSG00000149136 HEK293_DMSO_6hA HEK293_OSMI2_6hA SSRP1 protein_coding protein_coding 392.3231 352.6833 479.0824 24.76128 73.51612 0.4418897 340.76022 288.12045 417.50324 18.731987 64.14929 0.53509980 0.87997917 0.8176667 0.8712000 0.05353333 0.04029238 0.02433126 FALSE TRUE
ENST00000635721 ENSG00000149136 HEK293_DMSO_6hA HEK293_OSMI2_6hA SSRP1 protein_coding protein_coding 392.3231 352.6833 479.0824 24.76128 73.51612 0.4418897 42.42718 53.90619 52.59393 4.840976 9.54964 -0.03554801 0.09697083 0.1530667 0.1089667 -0.04410000 0.02433126 0.02433126 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000149136 E001 2.506662 7.828246e-03 0.35125368 0.74042632 11 57325986 57325986 1 - 0.474 0.622 0.688
ENSG00000149136 E002 2.506662 7.828246e-03 0.35125368 0.74042632 11 57325987 57325987 1 - 0.474 0.622 0.688
ENSG00000149136 E003 48.603327 2.816734e-03 0.97067743 0.99314851 11 57325988 57325999 12 - 1.696 1.696 0.000
ENSG00000149136 E004 286.286685 1.354685e-04 0.06084534 0.37374853 11 57326000 57326028 29 - 2.434 2.475 0.135
ENSG00000149136 E005 5905.483490 4.160601e-04 0.36195786 0.74822676 11 57326029 57326478 450 - 3.764 3.776 0.039
ENSG00000149136 E006 4199.128237 4.551103e-04 0.38522909 0.76385642 11 57326703 57326871 169 - 3.626 3.616 -0.032
ENSG00000149136 E007 1899.456438 2.003491e-04 0.57861071 0.86623350 11 57326872 57326889 18 - 3.278 3.272 -0.019
ENSG00000149136 E008 67.911330 1.564769e-01 0.01394347 0.20256009 11 57326890 57327425 536 - 1.602 2.002 1.353
ENSG00000149136 E009 3595.028587 1.792363e-04 0.91990985 0.98078516 11 57327426 57327511 86 - 3.552 3.553 0.003
ENSG00000149136 E010 2080.916907 1.856142e-04 0.55289308 0.85509611 11 57327512 57327514 3 - 3.311 3.318 0.022
ENSG00000149136 E011 4718.469155 8.643537e-04 0.83703446 0.95934453 11 57327712 57327882 171 - 3.670 3.675 0.015
ENSG00000149136 E012 18.865500 1.190027e-01 0.34585796 0.73600044 11 57328221 57328296 76 - 1.221 1.360 0.485
ENSG00000149136 E013 1779.582896 5.033753e-04 0.13881727 0.52355124 11 57328297 57328302 6 - 3.237 3.258 0.068
ENSG00000149136 E014 3976.521242 1.581613e-04 0.76848165 0.93908166 11 57328303 57328426 124 - 3.595 3.598 0.009
ENSG00000149136 E015 63.546990 2.275800e-01 0.03733345 0.30497852 11 57328427 57328643 217 - 1.606 1.959 1.192
ENSG00000149136 E016 220.880543 2.644420e-01 0.05258746 0.35157814 11 57328644 57330092 1449 - 2.139 2.498 1.199
ENSG00000149136 E017 2988.201250 4.562748e-05 0.00141628 0.06601955 11 57330093 57330138 46 - 3.460 3.483 0.077
ENSG00000149136 E018 4916.155384 1.430105e-04 0.18764305 0.58881501 11 57330291 57330429 139 - 3.684 3.694 0.035
ENSG00000149136 E019 35.693803 1.234412e-01 0.03418470 0.29466881 11 57330430 57330732 303 - 1.374 1.704 1.132
ENSG00000149136 E020 11.151071 2.383975e-02 0.20974034 0.61395264 11 57330733 57330741 9 - 0.994 1.152 0.575
ENSG00000149136 E021 26.378367 1.687457e-03 0.22927587 0.63439154 11 57330742 57330854 113 - 1.390 1.473 0.288
ENSG00000149136 E022 3628.371095 3.036015e-04 0.86537108 0.96713877 11 57330855 57330927 73 - 3.555 3.558 0.010
ENSG00000149136 E023 4913.610448 2.045481e-04 0.32974050 0.72433545 11 57331668 57331889 222 - 3.692 3.685 -0.025
ENSG00000149136 E024 3488.997546 1.278362e-04 0.06800401 0.39128044 11 57332152 57332280 129 - 3.545 3.532 -0.044
ENSG00000149136 E025 2266.954360 3.242792e-04 0.86689411 0.96735921 11 57332383 57332444 62 - 3.350 3.354 0.013
ENSG00000149136 E026 2081.783380 6.540592e-05 0.37145103 0.75415851 11 57332445 57332486 42 - 3.316 3.310 -0.021
ENSG00000149136 E027 3633.547958 9.228812e-05 0.07252302 0.40127272 11 57332625 57332834 210 - 3.562 3.550 -0.039
ENSG00000149136 E028 1361.918913 5.842557e-04 0.12689032 0.50558725 11 57332835 57332855 21 - 3.142 3.120 -0.073
ENSG00000149136 E029 43.239645 7.913011e-02 0.12355166 0.49988700 11 57332856 57332958 103 - 1.543 1.732 0.644
ENSG00000149136 E030 3429.726507 4.558845e-04 0.38619249 0.76464665 11 57332959 57333144 186 - 3.537 3.528 -0.029
ENSG00000149136 E031 1452.284273 1.072191e-03 0.64357242 0.89374182 11 57333145 57333149 5 - 3.161 3.157 -0.015
ENSG00000149136 E032 72.038914 1.472489e-01 0.08680438 0.43153234 11 57333150 57333434 285 - 1.724 1.977 0.856
ENSG00000149136 E033 1490.636999 3.891160e-03 0.72724657 0.92481426 11 57333435 57333437 3 - 3.177 3.168 -0.030
ENSG00000149136 E034 2876.717208 6.312861e-04 0.65639419 0.89928969 11 57333438 57333540 103 - 3.459 3.453 -0.018
ENSG00000149136 E035 3491.497477 5.013996e-04 0.09004068 0.43855639 11 57334463 57334648 186 - 3.549 3.530 -0.064
ENSG00000149136 E036 1918.928720 9.814862e-04 0.42438421 0.78893718 11 57335068 57335160 93 - 3.286 3.275 -0.034
ENSG00000149136 E037 1256.480953 1.203524e-03 0.42309741 0.78798593 11 57335161 57335240 80 - 3.102 3.091 -0.040
ENSG00000149136 E038 79.934302 3.985873e-04 0.09901504 0.45538950 11 57335241 57335281 41 - 1.868 1.935 0.224
ENSG00000149136 E039 60.688335 2.154263e-02 0.21426947 0.61870723 11 57335282 57335722 441 - 1.736 1.837 0.339
ENSG00000149136 E040 1.694049 2.888912e-01 0.80746306 0.95060030 11 57335723 57335725 3 - 0.392 0.447 0.293
ENSG00000149136 E041 2.878308 6.265391e-02 0.75284374 0.93351282 11 57335726 57335729 4 - 0.590 0.544 -0.212
ENSG00000149136 E042 514.568121 2.475138e-03 0.15302517 0.54350760 11 57335730 57336008 279 - 2.726 2.690 -0.119