ENSG00000148481

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000277632 ENSG00000148481 HEK293_DMSO_6hA HEK293_OSMI2_6hA MINDY3 protein_coding protein_coding 16.96318 5.389238 7.865921 1.855594 2.17918 0.5446928 10.1515736 3.56581709 5.0943189 1.15416355 1.3035365 0.5134455 0.63067083 0.670900000 0.65716667 -0.01373333 0.93650006 0.01956805 FALSE TRUE
ENST00000476912 ENSG00000148481 HEK293_DMSO_6hA HEK293_OSMI2_6hA MINDY3 protein_coding processed_transcript 16.96318 5.389238 7.865921 1.855594 2.17918 0.5446928 0.8919986 1.14263510 0.4688139 0.43070512 0.2529577 -1.2673990 0.06161667 0.208333333 0.04900000 -0.15933333 0.23896007 0.01956805   FALSE
ENST00000477891 ENSG00000148481 HEK293_DMSO_6hA HEK293_OSMI2_6hA MINDY3 protein_coding processed_transcript 16.96318 5.389238 7.865921 1.855594 2.17918 0.5446928 1.6079665 0.25808606 0.6188907 0.15408477 0.2786079 1.2301131 0.08451667 0.040300000 0.06883333 0.02853333 0.73962503 0.01956805 FALSE TRUE
MSTRG.3603.5 ENSG00000148481 HEK293_DMSO_6hA HEK293_OSMI2_6hA MINDY3 protein_coding   16.96318 5.389238 7.865921 1.855594 2.17918 0.5446928 2.6360893 0.08882432 1.2401750 0.08882432 0.3886052 3.6611202 0.13108333 0.009766667 0.16920000 0.15943333 0.01956805 0.01956805 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000148481 E001 1.283583 0.0128763660 4.916495e-02   10 15778170 15778173 4 - 0.182 0.521 2.154
ENSG00000148481 E002 86.870905 0.0005002543 2.144734e-01 0.618998076 10 15778174 15778853 680 - 1.931 1.973 0.139
ENSG00000148481 E003 68.160219 0.0005667172 7.783941e-01 0.941901838 10 15778854 15779141 288 - 1.856 1.843 -0.045
ENSG00000148481 E004 39.625807 0.0066145290 7.000167e-01 0.915035590 10 15782155 15782226 72 - 1.605 1.635 0.104
ENSG00000148481 E005 5.280277 0.0058106960 4.827039e-05 0.008738692 10 15782227 15782335 109 - 0.488 1.027 2.214
ENSG00000148481 E006 36.961916 0.0019859392 3.178294e-01 0.714897247 10 15786561 15786648 88 - 1.610 1.552 -0.195
ENSG00000148481 E007 1.784112 0.0996847250 6.033578e-01 0.877102799 10 15788828 15789246 419 - 0.513 0.404 -0.555
ENSG00000148481 E008 42.054096 0.0027584365 1.360226e-01 0.519359960 10 15789247 15789319 73 - 1.669 1.584 -0.290
ENSG00000148481 E009 33.082348 0.0027059440 4.040396e-01 0.776257716 10 15796100 15796119 20 - 1.554 1.503 -0.176
ENSG00000148481 E010 43.205783 0.0011580383 7.962630e-01 0.947012437 10 15796120 15796172 53 - 1.655 1.642 -0.046
ENSG00000148481 E011 33.030614 0.0008361396 2.152833e-01 0.619893133 10 15816835 15816915 81 - 1.511 1.580 0.237
ENSG00000148481 E012 0.000000       10 15816916 15818008 1093 -      
ENSG00000148481 E013 33.500847 0.0030152706 7.956645e-01 0.946740513 10 15821656 15821726 71 - 1.543 1.557 0.049
ENSG00000148481 E014 39.838951 0.0011155144 5.016429e-01 0.830481341 10 15833630 15833709 80 - 1.609 1.642 0.110
ENSG00000148481 E015 43.052450 0.0007723369 7.734921e-01 0.940467071 10 15834543 15834616 74 - 1.649 1.660 0.038
ENSG00000148481 E016 50.832093 0.0006071290 9.574026e-01 0.990246871 10 15837204 15837318 115 - 1.724 1.719 -0.018
ENSG00000148481 E017 1.132639 0.0144781553 8.982408e-01   10 15837542 15837633 92 - 0.361 0.334 -0.162
ENSG00000148481 E018 33.046926 0.0008834017 7.124905e-01 0.919442389 10 15838228 15838279 52 - 1.554 1.529 -0.085
ENSG00000148481 E019 50.728897 0.0006625580 8.706694e-01 0.968278564 10 15841426 15841599 174 - 1.724 1.728 0.015
ENSG00000148481 E020 28.658182 0.0011677201 5.717417e-01 0.862945118 10 15843212 15843272 61 - 1.500 1.459 -0.140
ENSG00000148481 E021 30.510185 0.0009269632 6.602913e-01 0.900683551 10 15847864 15847943 80 - 1.500 1.524 0.081
ENSG00000148481 E022 49.253638 0.0113193823 2.226729e-01 0.627325530 10 15860206 15860507 302 - 1.745 1.658 -0.294