ENSG00000147649

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336273 ENSG00000147649 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTDH protein_coding protein_coding 47.42244 6.761205 8.353399 1.555761 1.651239 0.3046767 24.8044261 4.5132837 6.2169299 1.2984809 1.22376724 0.4611506 0.62682500 0.6536667 0.74410000 0.09043333 4.824383e-01 2.020477e-11 FALSE TRUE
ENST00000519934 ENSG00000147649 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTDH protein_coding protein_coding 47.42244 6.761205 8.353399 1.555761 1.651239 0.3046767 1.4972694 0.8265169 0.5177622 0.2683706 0.25146662 -0.6645066 0.06015833 0.1173333 0.05456667 -0.06276667 4.976866e-01 2.020477e-11 FALSE TRUE
ENST00000521933 ENSG00000147649 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTDH protein_coding protein_coding 47.42244 6.761205 8.353399 1.555761 1.651239 0.3046767 0.5713540 0.8186169 0.1158886 0.1458405 0.06723976 -2.7185580 0.02963333 0.1392000 0.01473333 -0.12446667 8.205772e-02 2.020477e-11 FALSE FALSE
ENST00000522104 ENSG00000147649 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTDH protein_coding retained_intron 47.42244 6.761205 8.353399 1.555761 1.651239 0.3046767 0.7985069 0.6027877 0.2434901 0.1417765 0.12302981 -1.2734578 0.02530417 0.0898000 0.03406667 -0.05573333 5.149831e-01 2.020477e-11   FALSE
ENST00000522313 ENSG00000147649 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTDH protein_coding protein_coding 47.42244 6.761205 8.353399 1.555761 1.651239 0.3046767 19.6893154 0.0000000 1.2191635 0.0000000 0.24263865 6.9415330 0.25175417 0.0000000 0.14826667 0.14826667 2.020477e-11 2.020477e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000147649 E001 49.004468 0.0154352468 0.0140887410 0.20331196 8 97644184 97644545 362 + 1.749 1.632 -0.399
ENSG00000147649 E002 40.056987 0.0008108535 0.0525625931 0.35154120 8 97644546 97644792 247 + 1.635 1.608 -0.090
ENSG00000147649 E003 23.877837 0.0244413866 0.8718608895 0.96870249 8 97644793 97644887 95 + 1.362 1.458 0.332
ENSG00000147649 E004 39.801568 0.0151711594 0.2902323194 0.69151236 8 97661072 97661173 102 + 1.620 1.620 -0.001
ENSG00000147649 E005 52.573538 0.0187223787 0.1561466160 0.54824903 8 97686668 97686752 85 + 1.744 1.724 -0.069
ENSG00000147649 E006 82.237949 0.0036034694 0.0001454032 0.01689665 8 97687429 97687605 177 + 1.969 1.873 -0.323
ENSG00000147649 E007 49.414341 0.0007014871 0.0113689248 0.18444061 8 97689038 97689103 66 + 1.733 1.688 -0.153
ENSG00000147649 E008 51.059512 0.0050959350 0.0130006467 0.19620439 8 97690952 97691018 67 + 1.746 1.687 -0.200
ENSG00000147649 E009 72.560245 0.0022745036 0.0047791898 0.12411139 8 97691019 97691130 112 + 1.892 1.847 -0.152
ENSG00000147649 E010 65.893907 0.0009074926 0.0004224246 0.03261046 8 97691131 97691188 58 + 1.861 1.786 -0.254
ENSG00000147649 E011 68.946180 0.0005504601 0.0025185699 0.08981057 8 97699754 97699852 99 + 1.871 1.824 -0.158
ENSG00000147649 E012 3.215599 0.0267053938 0.0514271957 0.34811884 8 97706412 97706625 214 + 0.417 0.794 1.698
ENSG00000147649 E013 80.825509 0.0004004454 0.0265204199 0.26467552 8 97706626 97706750 125 + 1.924 1.920 -0.015
ENSG00000147649 E014 72.442566 0.0026649068 0.3161466770 0.71322882 8 97713662 97713769 108 + 1.859 1.895 0.119
ENSG00000147649 E015 90.559837 0.0130905225 0.5128769108 0.83653215 8 97719049 97719189 141 + 1.943 1.992 0.164
ENSG00000147649 E016 116.416286 0.0029145753 0.8890397636 0.97348772 8 97722879 97723035 157 + 2.032 2.124 0.306
ENSG00000147649 E017 1010.025200 0.0140401717 0.0020863472 0.08148375 8 97724600 97730260 5661 + 2.916 3.090 0.579