ENSG00000147403

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344746 ENSG00000147403 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPL10 protein_coding protein_coding 3790.646 3252.26 5630.204 481.2918 1342.325 0.7917428 276.9226 277.1206 468.5947 39.89414 99.08828 0.7578054 0.0748750 0.0854000 0.0849000 -0.00050000 0.99368662 0.002298796 FALSE  
ENST00000369817 ENSG00000147403 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPL10 protein_coding protein_coding 3790.646 3252.26 5630.204 481.2918 1342.325 0.7917428 1551.2063 1099.4872 2413.9826 167.24333 672.47707 1.1345773 0.4043375 0.3377667 0.4161667 0.07840000 0.14049740 0.002298796 FALSE  
ENST00000428169 ENSG00000147403 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPL10 protein_coding protein_coding 3790.646 3252.26 5630.204 481.2918 1342.325 0.7917428 1698.7836 1622.7239 2340.3094 249.11964 501.90719 0.5282790 0.4460750 0.4980000 0.4231333 -0.07486667 0.01618298 0.002298796    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000147403 E001 2.262475e+00 1.268549e-01 8.620142e-01 9.663555e-01 X 154389913 154389954 42 + 0.551 0.487 -0.306
ENSG00000147403 E002 4.832861e+00 3.287632e-01 9.538869e-01 9.892929e-01 X 154389955 154389972 18 + 0.803 0.713 -0.362
ENSG00000147403 E003 8.502496e+00 6.464511e-02 1.028861e-01 4.625105e-01 X 154397206 154397690 485 + 0.840 1.101 0.973
ENSG00000147403 E004 2.135162e+01 2.454179e-02 9.728059e-03 1.714579e-01 X 154397749 154397864 116 + 1.204 1.479 0.957
ENSG00000147403 E005 1.039707e+03 4.530706e-03 9.353998e-01 9.847872e-01 X 154398065 154398366 302 + 3.003 3.015 0.038
ENSG00000147403 E006 1.026769e+03 3.484963e-03 6.562201e-01 8.992333e-01 X 154398367 154398371 5 + 3.003 3.002 -0.004
ENSG00000147403 E007 1.165308e+03 3.298658e-03 7.204031e-01 9.223521e-01 X 154398372 154398376 5 + 3.057 3.059 0.007
ENSG00000147403 E008 1.167683e+03 3.260515e-03 7.281385e-01 9.250643e-01 X 154398377 154398377 1 + 3.058 3.060 0.007
ENSG00000147403 E009 1.159803e+03 3.456701e-03 7.165661e-01 9.208619e-01 X 154398378 154398378 1 + 3.055 3.057 0.007
ENSG00000147403 E010 1.357131e+03 2.891646e-03 4.928626e-01 8.258322e-01 X 154398379 154398387 9 + 3.126 3.120 -0.019
ENSG00000147403 E011 5.575139e+03 1.820585e-03 6.630783e-08 7.228818e-05 X 154398388 154398394 7 + 3.778 3.668 -0.365
ENSG00000147403 E012 6.537540e+02 1.273061e-02 7.145714e-01 9.202570e-01 X 154398395 154398398 4 + 2.808 2.806 -0.006
ENSG00000147403 E013 1.968859e+03 8.115694e-03 2.849792e-01 6.875592e-01 X 154398399 154398496 98 + 3.257 3.324 0.221
ENSG00000147403 E014 5.157735e+04 1.418835e-03 6.047650e-01 8.775273e-01 X 154398497 154398542 46 + 4.704 4.701 -0.009
ENSG00000147403 E015 1.962074e+02 3.351316e-01 7.487998e-02 4.067482e-01 X 154398543 154398619 77 + 2.080 2.482 1.344
ENSG00000147403 E016 1.453482e+02 1.783126e-01 1.971575e-02 2.341702e-01 X 154398890 154398960 71 + 1.923 2.368 1.490
ENSG00000147403 E017 5.684470e+04 1.045100e-03 5.623812e-01 8.590019e-01 X 154399338 154399365 28 + 4.746 4.744 -0.009
ENSG00000147403 E018 6.499693e+04 6.245661e-04 8.439948e-01 9.613058e-01 X 154399366 154399396 31 + 4.800 4.808 0.026
ENSG00000147403 E019 9.470828e+02 5.796750e-02 3.828640e-02 3.079893e-01 X 154399397 154399486 90 + 2.849 3.102 0.841
ENSG00000147403 E020 8.507621e+04 9.208531e-05 2.418526e-01 6.469572e-01 X 154399487 154399594 108 + 4.921 4.920 -0.003
ENSG00000147403 E021 8.694425e+02 5.477514e-02 1.808816e-01 5.804990e-01 X 154399595 154399802 208 + 2.855 3.024 0.559
ENSG00000147403 E022 6.083897e+04 1.033330e-03 1.072607e-01 4.704498e-01 X 154399803 154399882 80 + 4.783 4.763 -0.066
ENSG00000147403 E023 4.881284e+04 1.322409e-03 8.129599e-01 9.524005e-01 X 154399883 154399941 59 + 4.678 4.681 0.008
ENSG00000147403 E024 2.055162e+03 1.559282e-01 3.322306e-02 2.913351e-01 X 154399942 154400280 339 + 3.102 3.498 1.317
ENSG00000147403 E025 1.557184e+03 8.526083e-02 1.545860e-02 2.113120e-01 X 154400281 154400463 183 + 3.009 3.360 1.166
ENSG00000147403 E026 2.914889e+04 1.448739e-03 2.218479e-01 6.264741e-01 X 154400464 154400474 11 + 4.443 4.474 0.103
ENSG00000147403 E027 6.379633e+04 1.486493e-03 6.186349e-01 8.833195e-01 X 154400475 154400626 152 + 4.789 4.805 0.051
ENSG00000147403 E028 9.932437e+02 8.854179e-02 1.476597e-02 2.071169e-01 X 154400627 154400701 75 + 2.808 3.168 1.197
ENSG00000147403 E029 3.567362e+04 1.633734e-03 7.256072e-01 9.241863e-01 X 154400702 154402339 1638 + 4.539 4.549 0.036
ENSG00000147403 E030 3.968013e-01 3.634770e-02 9.568884e-01   X 154402928 154403262 335 + 0.171 0.150 -0.220
ENSG00000147403 E031 2.610453e+01 1.089576e-03 8.278269e-01 9.563676e-01 X 154403263 154403697 435 + 1.430 1.433 0.009
ENSG00000147403 E032 0.000000e+00       X 154409099 154409168 70 +