ENSG00000147274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320676 ENSG00000147274 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBMX protein_coding protein_coding 259.5824 101.7666 148.6749 20.75758 31.97897 0.5468531 167.94604 67.37899 119.645575 10.628527 28.3723575 0.8283027 0.67249167 0.67366667 0.79413333 0.12046667 0.03792966 0.03792966 FALSE TRUE
ENST00000419968 ENSG00000147274 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBMX protein_coding protein_coding 259.5824 101.7666 148.6749 20.75758 31.97897 0.5468531 17.67637 0.00000 0.000000 0.000000 0.0000000 0.0000000 0.05081667 0.00000000 0.00000000 0.00000000   0.03792966 FALSE TRUE
ENST00000496459 ENSG00000147274 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBMX protein_coding processed_transcript 259.5824 101.7666 148.6749 20.75758 31.97897 0.5468531 10.83332 8.77401 5.557752 2.657660 2.8072292 -0.6577847 0.05204167 0.08620000 0.03073333 -0.05546667 0.74294487 0.03792966 TRUE TRUE
MSTRG.34962.6 ENSG00000147274 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBMX protein_coding   259.5824 101.7666 148.6749 20.75758 31.97897 0.5468531 32.04405 4.91513 6.210804 2.467745 0.3343267 0.3369392 0.10099167 0.04446667 0.04806667 0.00360000 0.92351980 0.03792966 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000147274 E001 19.3100079 1.537075e-02 9.814923e-01 9.955881e-01 X 136848004 136848582 579 - 1.293 1.317 0.085
ENSG00000147274 E002 0.6870118 1.870834e-02 2.074011e-01   X 136869187 136869191 5 - 0.104 0.326 2.049
ENSG00000147274 E003 7.2854206 1.123126e-02 9.201836e-02 4.421553e-01 X 136869192 136869193 2 - 0.805 1.029 0.846
ENSG00000147274 E004 49.1418022 7.115474e-04 9.397188e-07 5.444751e-04 X 136869194 136869258 65 - 1.563 1.833 0.914
ENSG00000147274 E005 147.9698976 6.630092e-04 7.330486e-18 3.036819e-13 X 136869259 136869358 100 - 2.022 2.314 0.977
ENSG00000147274 E006 718.5646278 6.521305e-03 1.567319e-09 4.189015e-06 X 136869359 136869971 613 - 2.705 2.989 0.947
ENSG00000147274 E007 552.4918813 1.273797e-02 8.091436e-04 4.783531e-02 X 136869972 136870417 446 - 2.622 2.854 0.771
ENSG00000147274 E008 117.5432173 2.835643e-04 1.607443e-08 2.364384e-05 X 136872268 136872274 7 - 1.971 2.180 0.702
ENSG00000147274 E009 194.8652150 4.549952e-03 4.929362e-06 1.848098e-03 X 136872275 136872345 71 - 2.177 2.401 0.748
ENSG00000147274 E010 244.4481819 3.880752e-02 5.296220e-04 3.727288e-02 X 136872346 136873245 900 - 2.165 2.562 1.326
ENSG00000147274 E011 159.2235570 1.298132e-02 6.953423e-04 4.430007e-02 X 136873246 136873448 203 - 2.069 2.325 0.857
ENSG00000147274 E012 61.8875904 1.518891e-02 1.043322e-02 1.769760e-01 X 136873449 136873460 12 - 1.674 1.911 0.799
ENSG00000147274 E013 1328.8426416 2.078133e-03 4.877227e-01 8.232914e-01 X 136873461 136873957 497 - 3.104 3.143 0.129
ENSG00000147274 E014 342.4171644 6.297995e-03 5.041607e-01 8.318295e-01 X 136873958 136873977 20 - 2.539 2.527 -0.041
ENSG00000147274 E015 2033.7498380 2.390451e-03 2.391883e-01 6.444298e-01 X 136873978 136874452 475 - 3.310 3.303 -0.024
ENSG00000147274 E016 119.7727355 5.372745e-02 2.058309e-02 2.385083e-01 X 136874453 136875085 633 - 1.914 2.223 1.035
ENSG00000147274 E017 965.9595304 1.069437e-04 4.804388e-03 1.243657e-01 X 136875086 136875168 83 - 2.990 2.981 -0.028
ENSG00000147274 E018 1032.2803703 7.334949e-05 9.376487e-04 5.206999e-02 X 136875258 136875383 126 - 3.020 3.008 -0.039
ENSG00000147274 E019 910.1903839 1.623399e-04 8.279001e-04 4.852672e-02 X 136875471 136875585 115 - 2.969 2.951 -0.060
ENSG00000147274 E020 774.2412001 5.636227e-04 1.355362e-03 6.439095e-02 X 136876503 136876599 97 - 2.904 2.874 -0.100
ENSG00000147274 E021 674.0165719 2.968891e-04 8.434909e-06 2.708799e-03 X 136876600 136876655 56 - 2.851 2.805 -0.151
ENSG00000147274 E022 469.7915629 4.496576e-04 2.431257e-06 1.101719e-03 X 136877915 136877915 1 - 2.703 2.637 -0.220
ENSG00000147274 E023 714.6986707 8.919671e-04 3.079838e-04 2.693176e-02 X 136877916 136877964 49 - 2.875 2.828 -0.157
ENSG00000147274 E024 867.4427332 8.272531e-05 1.323396e-06 7.143279e-04 X 136877965 136878086 122 - 2.955 2.921 -0.114
ENSG00000147274 E025 983.1926550 3.763205e-04 2.038106e-05 4.959362e-03 X 136879017 136879123 107 - 3.008 2.973 -0.117
ENSG00000147274 E026 3.6981589 8.141179e-02 9.984870e-01 9.995553e-01 X 136879124 136879158 35 - 0.660 0.672 0.050
ENSG00000147274 E027 0.1717682 4.101483e-02 3.852630e-01   X 136879159 136879198 40 - 0.000 0.138 9.897
ENSG00000147274 E028 0.3435364 5.527230e-01 2.597492e-01   X 136879199 136879318 120 - 0.000 0.243 10.906
ENSG00000147274 E029 1035.5966449 3.192946e-03 7.865848e-03 1.553606e-01 X 136879319 136879453 135 - 3.035 2.987 -0.160
ENSG00000147274 E030 578.4566003 2.684683e-03 1.905011e-03 7.764131e-02 X 136880597 136880771 175 - 2.788 2.728 -0.199