ENSG00000147123

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377811 ENSG00000147123 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDUFB11 protein_coding protein_coding 247.3627 228.8198 373.5665 30.48687 73.06464 0.7071288 177.08441 158.94549 274.04693 21.569600 55.970677 0.7858528 0.7091500 0.69410000 0.7307667 0.03666667 0.19706723 0.02108787 FALSE  
ENST00000687244 ENSG00000147123 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDUFB11 protein_coding protein_coding 247.3627 228.8198 373.5665 30.48687 73.06464 0.7071288 24.44737 20.67830 42.90255 2.916349 9.514052 1.0525848 0.1023417 0.09016667 0.1132000 0.02303333 0.17523075 0.02108787 FALSE  
MSTRG.34175.3 ENSG00000147123 HEK293_DMSO_6hA HEK293_OSMI2_6hA NDUFB11 protein_coding   247.3627 228.8198 373.5665 30.48687 73.06464 0.7071288 44.51934 47.13582 55.46174 6.071837 7.739848 0.2346229 0.1814500 0.20630000 0.1525667 -0.05373333 0.02108787 0.02108787    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000147123 E001 3.401092 3.366607e-02 8.565459e-01 0.9646153893 X 47142071 47142215 145 - 0.617 0.651 0.145
ENSG00000147123 E002 341.235504 1.922807e-04 6.278548e-01 0.8869399422 X 47142216 47142239 24 - 2.529 2.535 0.017
ENSG00000147123 E003 4921.272275 3.072799e-05 1.822249e-05 0.0045960887 X 47142240 47142440 201 - 3.682 3.700 0.060
ENSG00000147123 E004 24.970332 3.131589e-03 6.047181e-03 0.1380454930 X 47142441 47142583 143 - 1.307 1.504 0.679
ENSG00000147123 E005 912.409999 3.301853e-04 1.333379e-02 0.1990951775 X 47142584 47142613 30 - 2.940 2.976 0.120
ENSG00000147123 E006 5885.054077 3.878265e-05 1.802402e-01 0.5795862248 X 47142614 47142737 124 - 3.765 3.769 0.014
ENSG00000147123 E007 3099.439801 3.157901e-05 6.630070e-01 0.9015007076 X 47142738 47142744 7 - 3.493 3.485 -0.024
ENSG00000147123 E008 41.131311 2.870201e-02 9.073354e-04 0.0510750230 X 47142745 47143595 851 - 1.444 1.773 1.119
ENSG00000147123 E009 10.764179 1.398880e-01 3.054296e-02 0.2816228488 X 47143596 47144047 452 - 0.844 1.253 1.497
ENSG00000147123 E010 7.283918 6.342922e-02 7.598270e-02 0.4090324935 X 47144048 47144296 249 - 0.762 1.044 1.073
ENSG00000147123 E011 2.127731 9.563301e-03 3.256128e-01 0.7213126278 X 47144297 47144472 176 - 0.409 0.568 0.789
ENSG00000147123 E012 3137.211459 3.133925e-05 2.508547e-01 0.6566374769 X 47144473 47144482 10 - 3.500 3.488 -0.040
ENSG00000147123 E013 5346.923279 1.666848e-04 1.768602e-06 0.0008827509 X 47144483 47145466 984 - 3.738 3.708 -0.099