ENSG00000147050

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377967 ENSG00000147050 HEK293_DMSO_6hA HEK293_OSMI2_6hA KDM6A protein_coding protein_coding 10.30295 6.183163 5.748629 1.799972 0.4969946 -0.1049511 0.7892331 0.19127994 0.74339950 0.19127994 0.19549175 1.9042117 0.0700125 0.019600000 0.13090000 0.11130000 0.251169981 0.005148141 FALSE TRUE
ENST00000414389 ENSG00000147050 HEK293_DMSO_6hA HEK293_OSMI2_6hA KDM6A protein_coding protein_coding 10.30295 6.183163 5.748629 1.799972 0.4969946 -0.1049511 1.1135405 1.55245043 1.84784143 0.28153034 0.34182317 0.2498169 0.1980417 0.271700000 0.32456667 0.05286667 0.770354708 0.005148141 FALSE TRUE
ENST00000675182 ENSG00000147050 HEK293_DMSO_6hA HEK293_OSMI2_6hA KDM6A protein_coding retained_intron 10.30295 6.183163 5.748629 1.799972 0.4969946 -0.1049511 1.3269759 0.75465012 0.07212766 0.11077937 0.07212766 -3.2188597 0.1086125 0.131766667 0.01236667 -0.11940000 0.080553525 0.005148141 FALSE TRUE
ENST00000675577 ENSG00000147050 HEK293_DMSO_6hA HEK293_OSMI2_6hA KDM6A protein_coding protein_coding 10.30295 6.183163 5.748629 1.799972 0.4969946 -0.1049511 2.3274650 1.13366135 0.77373218 0.27844359 0.26700068 -0.5452273 0.2044083 0.187633333 0.13250000 -0.05513333 0.717950601 0.005148141 FALSE TRUE
ENST00000683021 ENSG00000147050 HEK293_DMSO_6hA HEK293_OSMI2_6hA KDM6A protein_coding protein_coding 10.30295 6.183163 5.748629 1.799972 0.4969946 -0.1049511 1.6870184 1.26839567 0.51627984 0.59215840 0.34121388 -1.2804324 0.1404208 0.188900000 0.08570000 -0.10320000 0.612972394 0.005148141 FALSE TRUE
MSTRG.34148.18 ENSG00000147050 HEK293_DMSO_6hA HEK293_OSMI2_6hA KDM6A protein_coding   10.30295 6.183163 5.748629 1.799972 0.4969946 -0.1049511 0.9721724 0.07571843 0.82079143 0.07571843 0.16256464 3.2768091 0.0811000 0.007766667 0.13990000 0.13213333 0.005148141 0.005148141 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000147050 E001 9.4181488 0.0032321775 1.284388e-02 0.195220449 X 44873188 44873396 209 + 1.149 0.896 -0.930
ENSG00000147050 E002 7.5366817 0.0031114705 4.575113e-03 0.121396659 X 44873397 44873465 69 + 1.082 0.762 -1.212
ENSG00000147050 E003 8.3540805 0.0028751545 4.097992e-03 0.114643521 X 44873466 44873531 66 + 1.117 0.805 -1.168
ENSG00000147050 E004 5.2309282 0.0046787079 4.261074e-02 0.322310980 X 44873532 44873551 20 + 0.923 0.662 -1.041
ENSG00000147050 E005 15.9949094 0.0110857425 2.661895e-01 0.670934029 X 44873552 44873712 161 + 1.299 1.193 -0.371
ENSG00000147050 E006 0.0000000       X 44873715 44873797 83 +      
ENSG00000147050 E007 0.0000000       X 44873798 44873803 6 +      
ENSG00000147050 E008 0.0000000       X 44873804 44873878 75 +      
ENSG00000147050 E009 0.0000000       X 44873879 44873923 45 +      
ENSG00000147050 E010 13.4344558 0.0058670396 6.359789e-01 0.890658368 X 44873924 44873987 64 + 1.147 1.194 0.168
ENSG00000147050 E011 23.1304902 0.0189052248 9.704219e-01 0.993136174 X 44961284 44961392 109 + 1.397 1.385 -0.041
ENSG00000147050 E012 20.1229010 0.0021615864 6.874068e-01 0.910887707 X 44974666 44974715 50 + 1.345 1.317 -0.099
ENSG00000147050 E013 0.7187635 0.1501225628 2.911093e-01   X 44976652 44976708 57 + 0.309 0.114 -1.790
ENSG00000147050 E014 20.5205932 0.0157234144 7.357891e-01 0.927717957 X 45010961 45011019 59 + 1.318 1.345 0.097
ENSG00000147050 E015 0.5231092 0.2237644274 1.293223e-01   X 45018066 45020609 2544 + 0.000 0.280 11.922
ENSG00000147050 E016 29.3805556 0.0026798424 7.501676e-01 0.932574488 X 45020610 45020730 121 + 1.475 1.498 0.079
ENSG00000147050 E017 22.8545624 0.0014137991 6.570144e-01 0.899488553 X 45034931 45034985 55 + 1.359 1.396 0.130
ENSG00000147050 E018 20.4902023 0.0018200300 8.353816e-01 0.958664060 X 45037655 45037689 35 + 1.319 1.341 0.076
ENSG00000147050 E019 0.1544607 0.0326491905 5.460102e-01   X 45050910 45051708 799 + 0.000 0.114 10.325
ENSG00000147050 E020 27.0136117 0.0010492128 4.199867e-01 0.786044290 X 45051709 45051802 94 + 1.418 1.477 0.203
ENSG00000147050 E021 34.6375832 0.0008299296 5.254276e-01 0.842817352 X 45053829 45053955 127 + 1.530 1.573 0.147
ENSG00000147050 E022 0.1795728 0.0418733645 5.426908e-01   X 45053956 45057016 3061 + 0.000 0.114 10.328
ENSG00000147050 E023 29.6920286 0.0068937156 4.959695e-01 0.827318155 X 45059006 45059104 99 + 1.508 1.475 -0.116
ENSG00000147050 E024 23.4031983 0.0024115215 1.702396e-02 0.220803008 X 45059247 45059345 99 + 1.479 1.316 -0.566
ENSG00000147050 E025 23.4838531 0.0176012597 4.018471e-01 0.774702199 X 45059346 45059466 121 + 1.429 1.371 -0.200
ENSG00000147050 E026 23.7009823 0.0010952709 9.162681e-01 0.979910116 X 45060022 45060156 135 + 1.389 1.402 0.043
ENSG00000147050 E027 22.0214437 0.0013802488 5.747743e-01 0.864396978 X 45060609 45060764 156 + 1.345 1.391 0.159
ENSG00000147050 E028 34.4443457 0.0009249437 4.473678e-01 0.802121459 X 45061324 45061419 96 + 1.526 1.577 0.174
ENSG00000147050 E029 2.4787842 0.0086733754 3.290071e-05 0.006714216 X 45061528 45062646 1119 + 0.000 0.739 14.232
ENSG00000147050 E030 15.9976976 0.0026693132 3.464890e-01 0.736475245 X 45062647 45062748 102 + 1.274 1.202 -0.253
ENSG00000147050 E031 2.6567707 0.0337288735 7.057882e-01 0.917226256 X 45062749 45063421 673 + 0.525 0.600 0.341
ENSG00000147050 E032 73.9666273 0.0004415578 4.085394e-01 0.779391487 X 45063422 45063817 396 + 1.895 1.867 -0.095
ENSG00000147050 E033 0.4610554 0.0220223436 5.045530e-01   X 45068581 45069043 463 + 0.223 0.114 -1.167
ENSG00000147050 E034 103.1776149 0.0011322920 5.914649e-01 0.872007776 X 45069579 45070028 450 + 2.027 2.013 -0.047
ENSG00000147050 E035 53.0971984 0.0065778083 8.045611e-01 0.949643020 X 45070029 45070119 91 + 1.741 1.734 -0.024
ENSG00000147050 E036 86.2731438 0.0003756067 5.393395e-01 0.849521260 X 45070120 45070357 238 + 1.951 1.934 -0.058
ENSG00000147050 E037 2.0208801 0.1803156292 7.146462e-02 0.398630047 X 45070358 45076696 6339 + 0.223 0.605 2.177
ENSG00000147050 E038 62.1345931 0.0005882168 7.892363e-01 0.944756228 X 45076697 45076826 130 + 1.803 1.796 -0.022
ENSG00000147050 E039 58.3478403 0.0049581695 2.431261e-01 0.648188813 X 45078400 45078505 106 + 1.803 1.740 -0.211
ENSG00000147050 E040 0.9640548 0.0576070099 8.945519e-01   X 45078579 45079145 567 + 0.303 0.278 -0.172
ENSG00000147050 E041 85.2797858 0.0003726485 1.124066e-01 0.479927791 X 45079146 45079351 206 + 1.968 1.915 -0.179
ENSG00000147050 E042 0.6199555 0.0193874923 8.993820e-01   X 45079352 45080665 1314 + 0.223 0.204 -0.168
ENSG00000147050 E043 0.0000000       X 45082398 45082575 178 +      
ENSG00000147050 E044 29.7635185 0.0009712123 1.273379e-02 0.194551253 X 45082576 45082585 10 + 1.395 1.559 0.565
ENSG00000147050 E045 43.3568719 0.0017685064 1.368238e-01 0.520645437 X 45082586 45082640 55 + 1.604 1.691 0.294
ENSG00000147050 E046 10.4149568 0.1463968801 2.367663e-01 0.641701945 X 45082641 45082714 74 + 0.921 1.143 0.812
ENSG00000147050 E047 54.5894798 0.0013371576 7.508611e-01 0.932803767 X 45082715 45082789 75 + 1.740 1.759 0.065
ENSG00000147050 E048 0.1125166 0.0327118680 4.419265e-01   X 45082790 45083459 670 + 0.125 0.000 -10.825
ENSG00000147050 E049 43.2739816 0.0010569042 2.687055e-01 0.673285231 X 45083460 45083518 59 + 1.615 1.678 0.212
ENSG00000147050 E050 56.0114758 0.0007135746 9.289055e-01 0.983061383 X 45083519 45083608 90 + 1.754 1.762 0.027
ENSG00000147050 E051 60.3994359 0.0004860070 3.761140e-01 0.757386371 X 45085865 45085979 115 + 1.809 1.775 -0.116
ENSG00000147050 E052 0.6825723 0.0193874923 3.777364e-01   X 45085980 45086374 395 + 0.126 0.278 1.415
ENSG00000147050 E053 75.0545932 0.0012156548 7.168195e-01 0.920937971 X 45089743 45089930 188 + 1.872 1.892 0.067
ENSG00000147050 E054 61.5851302 0.0005531772 6.320265e-01 0.888828902 X 45090723 45090816 94 + 1.788 1.815 0.089
ENSG00000147050 E055 48.5416328 0.0005889291 7.732506e-01 0.940422304 X 45090817 45090832 16 + 1.687 1.707 0.066
ENSG00000147050 E056 44.1337290 0.0009458980 9.189372e-01 0.980548121 X 45090833 45090864 32 + 1.659 1.658 -0.003
ENSG00000147050 E057 19.2411533 0.0674922889 3.772004e-02 0.306226671 X 45104224 45106541 2318 + 1.113 1.406 1.032
ENSG00000147050 E058 8.5828756 0.0029707763 8.460671e-01 0.961847151 X 45106542 45106649 108 + 0.988 0.972 -0.061
ENSG00000147050 E059 6.3792919 0.0121231503 9.626979e-01 0.991467572 X 45106650 45106713 64 + 0.850 0.862 0.046
ENSG00000147050 E060 16.2038865 0.0617542495 7.249861e-01 0.923979388 X 45106714 45107409 696 + 1.218 1.239 0.073
ENSG00000147050 E061 75.7769585 0.0034148732 4.727217e-01 0.815389963 X 45107410 45107536 127 + 1.863 1.898 0.118
ENSG00000147050 E062 101.6248765 0.0016348519 9.579807e-01 0.990476682 X 45110079 45110249 171 + 2.008 2.011 0.010
ENSG00000147050 E063 194.7147063 0.0099264632 6.535431e-01 0.897940969 X 45111382 45112779 1398 + 2.278 2.298 0.064