ENSG00000146909

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275820 ENSG00000146909 HEK293_DMSO_6hA HEK293_OSMI2_6hA NOM1 protein_coding protein_coding 20.85867 19.23201 18.29695 4.502195 0.4064609 -0.07186824 10.8892079 8.90272540 8.7018015 1.18941137 1.1048207 -0.03289557 0.52388750 0.4832667 0.47456667 -0.008700000 0.98648353 0.01595342 FALSE  
ENST00000469271 ENSG00000146909 HEK293_DMSO_6hA HEK293_OSMI2_6hA NOM1 protein_coding retained_intron 20.85867 19.23201 18.29695 4.502195 0.4064609 -0.07186824 1.9436147 2.32611979 1.6641484 0.29459320 0.1424444 -0.48068686 0.09230000 0.1267000 0.09123333 -0.035466667 0.60024443 0.01595342 FALSE  
ENST00000485661 ENSG00000146909 HEK293_DMSO_6hA HEK293_OSMI2_6hA NOM1 protein_coding retained_intron 20.85867 19.23201 18.29695 4.502195 0.4064609 -0.07186824 3.3645613 4.40010501 3.1954672 1.70497473 1.0256300 -0.46027835 0.16133750 0.2138333 0.17286667 -0.040966667 0.75317231 0.01595342 FALSE  
MSTRG.30987.7 ENSG00000146909 HEK293_DMSO_6hA HEK293_OSMI2_6hA NOM1 protein_coding   20.85867 19.23201 18.29695 4.502195 0.4064609 -0.07186824 0.4175121 0.06183041 1.0966997 0.06183041 0.3857933 3.94552529 0.02510000 0.0022000 0.06033333 0.058133333 0.01595342 0.01595342 TRUE  
MSTRG.30987.8 ENSG00000146909 HEK293_DMSO_6hA HEK293_OSMI2_6hA NOM1 protein_coding   20.85867 19.23201 18.29695 4.502195 0.4064609 -0.07186824 1.4325865 0.63158548 0.6843344 0.34168995 0.3425521 0.11398907 0.06601667 0.0311000 0.03826667 0.007166667 0.98281528 0.01595342 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000146909 E001 0.0000000       7 156949599 156949705 107 +      
ENSG00000146909 E002 0.0000000       7 156949706 156949711 6 +      
ENSG00000146909 E003 0.1125166 0.0325774099 5.049204e-01   7 156949712 156949721 10 + 0.116 0.000 -8.804
ENSG00000146909 E004 59.4003387 0.0193422569 3.594283e-01 7.465033e-01 7 156949722 156949932 211 + 1.818 1.749 -0.231
ENSG00000146909 E005 40.0781216 0.0111353800 1.436348e-01 5.304600e-01 7 156949933 156949974 42 + 1.664 1.563 -0.343
ENSG00000146909 E006 50.9634400 0.0254372303 3.460217e-01 7.361240e-01 7 156949975 156950048 74 + 1.753 1.675 -0.264
ENSG00000146909 E007 146.9035615 0.0004424070 4.391003e-02 3.262735e-01 7 156950049 156950426 378 + 2.194 2.146 -0.159
ENSG00000146909 E008 219.6872703 0.0001895209 3.279654e-02 2.902677e-01 7 156950427 156950724 298 + 2.365 2.328 -0.124
ENSG00000146909 E009 3.6114394 0.2101933826 8.514810e-01 9.632941e-01 7 156952471 156952473 3 + 0.652 0.664 0.050
ENSG00000146909 E010 136.3409484 0.0002449570 2.207643e-02 2.457685e-01 7 156952474 156952585 112 + 2.166 2.110 -0.186
ENSG00000146909 E011 54.2889354 0.0037968385 7.265319e-02 4.014836e-01 7 156952586 156952598 13 + 1.788 1.699 -0.300
ENSG00000146909 E012 55.6084287 0.0005821971 1.239455e-02 1.922452e-01 7 156954103 156954111 9 + 1.804 1.699 -0.355
ENSG00000146909 E013 145.6247615 0.0006835296 1.180601e-04 1.479851e-02 7 156954112 156954298 187 + 2.218 2.112 -0.354
ENSG00000146909 E014 12.9973786 0.0428770520 9.933600e-01 9.983823e-01 7 156958606 156958856 251 + 1.138 1.148 0.037
ENSG00000146909 E015 131.7485431 0.0002976342 1.871525e-02 2.295888e-01 7 156959851 156959995 145 + 2.152 2.093 -0.198
ENSG00000146909 E016 154.8663143 0.0002244680 3.526054e-03 1.068968e-01 7 156959996 156960174 179 + 2.228 2.159 -0.230
ENSG00000146909 E017 13.2143660 0.0998151179 4.892867e-01 8.242502e-01 7 156960175 156960253 79 + 1.095 1.196 0.361
ENSG00000146909 E018 66.5864903 0.0004223875 4.168782e-02 3.195359e-01 7 156962151 156962167 17 + 1.868 1.793 -0.251
ENSG00000146909 E019 63.1291467 0.0004474950 4.774257e-02 3.378363e-01 7 156962168 156962170 3 + 1.844 1.770 -0.250
ENSG00000146909 E020 113.9443927 0.0002642210 1.147226e-02 1.851858e-01 7 156962171 156962261 91 + 2.097 2.027 -0.234
ENSG00000146909 E021 141.0938157 0.0035936239 2.190946e-01 6.237388e-01 7 156963008 156963175 168 + 2.176 2.136 -0.136
ENSG00000146909 E022 68.6377454 0.0271483846 4.158471e-02 3.191441e-01 7 156963176 156963904 729 + 1.735 1.923 0.634
ENSG00000146909 E023 115.4793146 0.0003403876 5.019265e-01 8.306326e-01 7 156963905 156964026 122 + 2.075 2.066 -0.032
ENSG00000146909 E024 20.6039094 0.1270631150 3.761177e-01 7.573864e-01 7 156964027 156964235 209 + 1.276 1.378 0.359
ENSG00000146909 E025 18.0842754 0.2173762957 2.033180e-01 6.071753e-01 7 156966159 156966269 111 + 1.151 1.372 0.780
ENSG00000146909 E026 134.1464004 0.0006605228 1.181575e-01 4.903643e-01 7 156966270 156966402 133 + 2.149 2.113 -0.121
ENSG00000146909 E027 140.7437728 0.0009833971 7.661717e-01 9.381834e-01 7 156966961 156967092 132 + 2.141 2.164 0.075
ENSG00000146909 E028 13.8184030 0.1262119803 2.566986e-02 2.608559e-01 7 156968755 156969086 332 + 0.919 1.320 1.445
ENSG00000146909 E029 129.4974542 0.0014194077 6.592204e-01 9.003319e-01 7 156969087 156969196 110 + 2.107 2.133 0.086
ENSG00000146909 E030 277.4530857 0.0030430139 4.418286e-02 3.271447e-01 7 156969529 156970605 1077 + 2.404 2.481 0.259
ENSG00000146909 E031 566.2098689 0.0008078814 9.570113e-11 3.964635e-07 7 156970606 156972635 2030 + 2.683 2.811 0.426
ENSG00000146909 E032 139.5632487 0.0002841543 4.084372e-07 2.955533e-04 7 156972636 156973176 541 + 2.056 2.220 0.548