ENSG00000146670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275517 ENSG00000146670 HEK293_DMSO_6hA HEK293_OSMI2_6hA CDCA5 protein_coding protein_coding 117.2038 109.4051 153.3279 10.78778 19.9586 0.4869024 82.28056 77.52667 100.3244 8.987725 15.389374 0.3718656 0.6977875 0.7059000 0.6499333 -0.05596667 0.331993693 0.002009346 FALSE  
MSTRG.5698.4 ENSG00000146670 HEK293_DMSO_6hA HEK293_OSMI2_6hA CDCA5 protein_coding   117.2038 109.4051 153.3279 10.78778 19.9586 0.4869024 24.86707 20.44684 41.0416 1.723464 5.225589 1.0048553 0.2095333 0.1881667 0.2681667 0.08000000 0.002009346 0.002009346 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000146670 E001 0.5763742 2.237817e-02 0.807444202   11 65066300 65066364 65 - 0.192 0.235 0.366
ENSG00000146670 E002 1.6450799 1.043180e-02 0.621445083 0.88461549 11 65066365 65066473 109 - 0.471 0.387 -0.447
ENSG00000146670 E003 1.1279574 2.381596e-02 0.956099470   11 65066474 65066551 78 - 0.327 0.317 -0.062
ENSG00000146670 E004 2.0008604 9.232160e-03 0.870544563 0.96826117 11 65066552 65066679 128 - 0.471 0.499 0.138
ENSG00000146670 E005 1.5683434 1.829872e-02 0.324670415   11 65066813 65066879 67 - 0.325 0.499 0.952
ENSG00000146670 E006 0.0000000       11 65067655 65067753 99 -      
ENSG00000146670 E007 0.1795728 3.225110e-02 0.390166151   11 65068027 65068043 17 - 0.000 0.133 8.766
ENSG00000146670 E008 0.0000000       11 65068044 65068118 75 -      
ENSG00000146670 E009 0.7547820 1.698757e-02 0.267343496   11 65068488 65068601 114 - 0.326 0.133 -1.640
ENSG00000146670 E010 4825.5485532 1.914899e-04 0.017837076 0.22508958 11 65077453 65078632 1180 - 3.671 3.691 0.067
ENSG00000146670 E011 2312.3750799 7.367414e-05 0.987214946 0.99685859 11 65078633 65079087 455 - 3.358 3.362 0.013
ENSG00000146670 E012 666.6084590 8.238239e-05 0.086940214 0.43182621 11 65079088 65079131 44 - 2.829 2.808 -0.069
ENSG00000146670 E013 496.7127780 9.099436e-05 0.427968543 0.79087151 11 65079132 65079140 9 - 2.697 2.687 -0.032
ENSG00000146670 E014 574.8891211 8.326865e-05 0.284146145 0.68691202 11 65079141 65079165 25 - 2.761 2.748 -0.043
ENSG00000146670 E015 618.2544378 8.353701e-05 0.960805316 0.99102761 11 65079166 65079187 22 - 2.785 2.789 0.013
ENSG00000146670 E016 77.0992690 5.202039e-02 0.035298817 0.29819187 11 65079188 65079352 165 - 1.766 1.998 0.783
ENSG00000146670 E017 1277.7774703 7.690305e-05 0.539453540 0.84953631 11 65079353 65079549 197 - 3.104 3.101 -0.010
ENSG00000146670 E018 1125.6880735 4.330963e-04 0.912449735 0.97909716 11 65079550 65079787 238 - 3.047 3.052 0.017
ENSG00000146670 E019 18.7149235 1.169613e-01 0.120347034 0.49424006 11 65083250 65083363 114 - 1.150 1.409 0.909
ENSG00000146670 E020 583.0910229 8.443753e-05 0.600914502 0.87585858 11 65083364 65083399 36 - 2.756 2.767 0.036
ENSG00000146670 E021 27.3428230 3.618346e-02 0.018484379 0.22852674 11 65083400 65083484 85 - 1.308 1.568 0.898
ENSG00000146670 E022 598.9722747 1.104194e-04 0.794881079 0.94648800 11 65083485 65083550 66 - 2.775 2.774 -0.004
ENSG00000146670 E023 634.5630952 5.341281e-04 0.192010440 0.59412664 11 65083629 65083716 88 - 2.809 2.790 -0.063
ENSG00000146670 E024 302.9906601 1.397995e-03 0.438352496 0.79672436 11 65083717 65083723 7 - 2.486 2.471 -0.051
ENSG00000146670 E025 84.3328724 3.130716e-03 0.426969926 0.79038350 11 65083724 65083932 209 - 1.907 1.949 0.138
ENSG00000146670 E026 430.4702268 1.730845e-04 0.000483822 0.03533243 11 65083933 65084048 116 - 2.658 2.599 -0.197
ENSG00000146670 E027 106.3002635 3.110722e-04 0.015382725 0.21082290 11 65084049 65084070 22 - 2.064 1.983 -0.273
ENSG00000146670 E028 46.5737284 4.075261e-03 0.037351795 0.30505316 11 65084071 65084075 5 - 1.730 1.608 -0.411
ENSG00000146670 E029 37.5829843 1.180927e-02 0.388338447 0.76600884 11 65084076 65084156 81 - 1.612 1.553 -0.202
ENSG00000146670 E030 10.1634459 3.140120e-03 0.003917217 0.11191990 11 65084157 65084219 63 - 1.159 0.852 -1.138