ENSG00000145730

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348126 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding protein_coding 22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 5.354928 3.26416144 3.2876120 0.46540262 0.9473338 0.01029620 0.23901667 0.28803333 0.21200000 -0.076033333 0.33902977 0.04590299 FALSE TRUE
ENST00000379799 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding protein_coding 22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 4.319389 3.34756599 3.5703634 1.04363309 1.7851954 0.09269027 0.19667917 0.27150000 0.18660000 -0.084900000 0.78667576 0.04590299 FALSE TRUE
ENST00000455264 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding protein_coding 22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 1.946466 0.87014714 0.8461594 0.22030691 0.2894565 -0.03986538 0.08306250 0.07336667 0.05953333 -0.013833333 0.76303670 0.04590299 FALSE TRUE
ENST00000504456 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding protein_coding 22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 1.302231 0.94674016 1.1433180 0.27152587 0.4764111 0.26959132 0.06658750 0.09003333 0.08040000 -0.009633333 0.95107030 0.04590299 FALSE TRUE
ENST00000504691 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding protein_coding 22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 1.762541 0.95305292 1.6517843 0.24720490 0.6532619 0.78704616 0.08397917 0.07956667 0.10026667 0.020700000 0.75877377 0.04590299 FALSE TRUE
ENST00000682882 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding protein_coding 22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 1.510983 0.35759510 0.5562070 0.35759510 0.5562070 0.62321199 0.07017500 0.04796667 0.07623333 0.028266667 0.99795753 0.04590299 FALSE TRUE
ENST00000682972 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding protein_coding 22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 1.934655 0.82756292 1.0852560 0.71077472 0.6260133 0.38699870 0.08100833 0.05380000 0.07380000 0.020000000 0.74897224 0.04590299 FALSE TRUE
MSTRG.26679.6 ENSG00000145730 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAM protein_coding   22.22692 11.68311 15.25075 2.443633 4.050661 0.3841675 1.021519 0.09945287 1.0712249 0.05197434 0.2087169 3.30428498 0.04559167 0.01040000 0.07450000 0.064100000 0.04590299 0.04590299 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000145730 E001 0.0000000       5 102753981 102754090 110 +      
ENSG00000145730 E002 0.0000000       5 102754667 102754723 57 +      
ENSG00000145730 E003 0.1767706 0.1171322073 0.561769652   5 102754724 102754782 59 + 0.111 0.000 -11.326
ENSG00000145730 E004 0.1767706 0.1171322073 0.561769652   5 102754783 102754790 8 + 0.111 0.000 -11.325
ENSG00000145730 E005 0.2892872 0.0264806591 0.253694135   5 102754791 102754945 155 + 0.198 0.000 -12.313
ENSG00000145730 E006 4.6268298 0.0062216063 0.288552526 0.69027083 5 102754946 102755254 309 + 0.830 0.683 -0.594
ENSG00000145730 E007 6.3168507 0.0052255642 0.039187939 0.31149778 5 102755255 102755297 43 + 0.972 0.713 -1.009
ENSG00000145730 E008 5.6203971 0.0418534239 0.054540957 0.35716625 5 102755298 102755304 7 + 0.943 0.650 -1.163
ENSG00000145730 E009 6.7074237 0.0039068853 0.006141061 0.13898016 5 102755305 102755313 9 + 1.023 0.683 -1.321
ENSG00000145730 E010 8.2918486 0.0030684275 0.003814563 0.11054695 5 102755314 102755321 8 + 1.099 0.768 -1.250
ENSG00000145730 E011 15.0471453 0.0021632761 0.002285919 0.08512823 5 102755322 102755342 21 + 1.315 1.044 -0.965
ENSG00000145730 E012 14.5283855 0.0044615777 0.007487029 0.15221053 5 102755343 102755348 6 + 1.291 1.044 -0.879
ENSG00000145730 E013 0.0000000       5 102755349 102755469 121 +      
ENSG00000145730 E014 0.0000000       5 102808057 102808062 6 +      
ENSG00000145730 E015 0.0000000       5 102808063 102808231 169 +      
ENSG00000145730 E016 0.1125166 0.0320261617 0.565191686   5 102837687 102837792 106 + 0.110 0.000 -11.310
ENSG00000145730 E017 0.1125166 0.0320261617 0.565191686   5 102838221 102838589 369 + 0.110 0.000 -11.310
ENSG00000145730 E018 0.0000000       5 102864537 102864567 31 +      
ENSG00000145730 E019 0.1125166 0.0320261617 0.565191686   5 102865244 102865272 29 + 0.110 0.000 -11.310
ENSG00000145730 E020 0.0000000       5 102865310 102865467 158 +      
ENSG00000145730 E021 0.0000000       5 102865479 102865510 32 +      
ENSG00000145730 E022 0.0000000       5 102865737 102865818 82 +      
ENSG00000145730 E023 0.1544607 0.0327295291 0.425490679   5 102865819 102865822 4 + 0.000 0.129 11.674
ENSG00000145730 E024 61.1891383 0.0013195565 0.002075764 0.08125980 5 102865823 102866284 462 + 1.864 1.722 -0.480
ENSG00000145730 E025 0.1717682 0.0557979122 0.425079292   5 102866587 102866716 130 + 0.000 0.130 11.676
ENSG00000145730 E026 53.5678954 0.0006064092 0.110293771 0.47609573 5 102867273 102867393 121 + 1.780 1.705 -0.254
ENSG00000145730 E027 0.9746617 0.0144778232 0.302833199   5 102873293 102873804 512 + 0.198 0.378 1.265
ENSG00000145730 E028 0.5108041 0.0222832870 0.478973824   5 102895913 102895962 50 + 0.110 0.229 1.262
ENSG00000145730 E029 0.1812101 0.0351435849 0.563056385   5 102899936 102900002 67 + 0.111 0.000 -11.318
ENSG00000145730 E030 49.0982811 0.0127617106 0.451308709 0.80431623 5 102901356 102901413 58 + 1.679 1.739 0.202
ENSG00000145730 E031 59.8146805 0.0030676140 0.800819684 0.94851529 5 102913934 102914021 88 + 1.798 1.787 -0.035
ENSG00000145730 E032 53.8653860 0.0006142329 0.018854602 0.23018066 5 102924957 102925042 86 + 1.794 1.683 -0.376
ENSG00000145730 E033 52.4158252 0.0006207767 0.681042301 0.90852243 5 102926585 102926668 84 + 1.741 1.722 -0.063
ENSG00000145730 E034 41.0536508 0.0013024836 0.654040730 0.89816304 5 102946837 102946885 49 + 1.612 1.637 0.087
ENSG00000145730 E035 45.0141931 0.0043604937 0.768900042 0.93915085 5 102948378 102948445 68 + 1.651 1.673 0.075
ENSG00000145730 E036 38.0013028 0.0051608937 0.865564589 0.96713877 5 102949537 102949576 40 + 1.596 1.589 -0.026
ENSG00000145730 E037 38.7106754 0.0098115003 0.342879912 0.73411747 5 102949577 102949617 41 + 1.628 1.568 -0.203
ENSG00000145730 E038 53.0442252 0.0015413990 0.797571321 0.94747461 5 102949902 102949978 77 + 1.731 1.747 0.053
ENSG00000145730 E039 54.6859181 0.0005476033 0.784916336 0.94370201 5 102950717 102950820 104 + 1.747 1.760 0.045
ENSG00000145730 E040 71.1187151 0.0004734728 0.726654487 0.92456923 5 102959875 102959996 122 + 1.870 1.856 -0.046
ENSG00000145730 E041 57.3213523 0.0051012885 0.860227868 0.96574657 5 102959997 102960059 63 + 1.772 1.770 -0.007
ENSG00000145730 E042 62.2543846 0.0010132963 0.757538030 0.93506243 5 102961158 102961229 72 + 1.798 1.814 0.055
ENSG00000145730 E043 52.2263927 0.0005363002 0.085105269 0.42821799 5 102974116 102974298 183 + 1.769 1.686 -0.280
ENSG00000145730 E044 40.1923146 0.0037370680 0.076673070 0.41054229 5 102974299 102974390 92 + 1.670 1.557 -0.385
ENSG00000145730 E045 32.0178708 0.0009480840 0.051729285 0.34907541 5 102974391 102974436 46 + 1.573 1.454 -0.409
ENSG00000145730 E046 0.9393572 0.0162730173 0.140390409   5 102974437 102974837 401 + 0.389 0.130 -2.058
ENSG00000145730 E047 1.3506393 0.0118365489 0.014482220   5 102989771 102990271 501 + 0.110 0.535 3.070
ENSG00000145730 E048 90.1136870 0.0050460941 0.571047404 0.86269083 5 102990272 102990401 130 + 1.945 1.980 0.115
ENSG00000145730 E049 95.7940120 0.0004385605 0.004801110 0.12436572 5 103003033 103003149 117 + 1.937 2.039 0.341
ENSG00000145730 E050 69.5003687 0.0004470254 0.044308686 0.32763446 5 103005154 103005226 73 + 1.810 1.894 0.284
ENSG00000145730 E051 126.6316954 0.0002939447 0.055541341 0.35979389 5 103006801 103007006 206 + 2.081 2.140 0.198
ENSG00000145730 E052 44.3243385 0.0097625535 0.889640384 0.97357303 5 103007007 103007011 5 + 1.666 1.664 -0.007
ENSG00000145730 E053 97.6106184 0.0020629628 0.325730379 0.72137991 5 103007457 103007558 102 + 1.983 2.020 0.123
ENSG00000145730 E054 60.8689296 0.0042191564 0.172280809 0.56976084 5 103007559 103007568 10 + 1.765 1.834 0.234
ENSG00000145730 E055 87.2558295 0.0003781799 0.304039840 0.70306478 5 103007569 103007657 89 + 1.934 1.972 0.127
ENSG00000145730 E056 100.4540946 0.0004166175 0.382142554 0.76158730 5 103009751 103009866 116 + 1.998 2.028 0.101
ENSG00000145730 E057 111.7121508 0.0017521963 0.679009039 0.90767838 5 103017334 103017433 100 + 2.051 2.063 0.041
ENSG00000145730 E058 99.3589996 0.0003578876 0.853074977 0.96356327 5 103019790 103019843 54 + 2.009 2.003 -0.021
ENSG00000145730 E059 28.0634285 0.0010823036 0.622498364 0.88518261 5 103025131 103025133 3 + 1.454 1.485 0.105
ENSG00000145730 E060 89.2910489 0.0005469836 0.280094760 0.68321969 5 103025134 103025334 201 + 1.940 1.980 0.134
ENSG00000145730 E061 32.6770537 0.0008352352 0.905616032 0.97766072 5 103028182 103028184 3 + 1.538 1.531 -0.023
ENSG00000145730 E062 98.2510519 0.0003620069 0.710864716 0.91910987 5 103028185 103028238 54 + 1.994 2.007 0.044
ENSG00000145730 E063 343.4586706 0.0053438760 0.845460539 0.96172718 5 103028887 103029730 844 + 2.534 2.541 0.024