ENSG00000144724

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295874 ENSG00000144724 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPRG protein_coding protein_coding 4.229887 1.208461 1.79173 0.1840578 0.2924352 0.5643231 2.2374479 0.24924906 1.1140931 0.03297167 0.18733381 2.1163508 0.4792167 0.2227000 0.6205333 0.39783333 0.01111552 0.01111552 FALSE TRUE
ENST00000468576 ENSG00000144724 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPRG protein_coding retained_intron 4.229887 1.208461 1.79173 0.1840578 0.2924352 0.5643231 0.2505829 0.08965803 0.1518507 0.01642648 0.06243186 0.6996057 0.0681625 0.0806000 0.1033333 0.02273333 0.98347094 0.01111552   FALSE
ENST00000474889 ENSG00000144724 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPRG protein_coding protein_coding 4.229887 1.208461 1.79173 0.1840578 0.2924352 0.5643231 1.5134677 0.66064922 0.5231259 0.08706259 0.16595859 -0.3310822 0.3504083 0.5505667 0.2739667 -0.27660000 0.22099408 0.01111552 FALSE TRUE
ENST00000475012 ENSG00000144724 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPRG protein_coding processed_transcript 4.229887 1.208461 1.79173 0.1840578 0.2924352 0.5643231 0.1694770 0.19177745 0.0000000 0.14337117 0.00000000 -4.3346931 0.0901250 0.1314000 0.0000000 -0.13140000 0.30110583 0.01111552 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000144724 E001 0.6277602 0.019307461 0.7411329822   3 61561569 61561570 2 + 0.186 0.243 0.491
ENSG00000144724 E002 8.4991452 0.004653696 0.0465163940 0.33446954 3 61561571 61561850 280 + 0.870 1.089 0.813
ENSG00000144724 E003 3.0615231 0.007253023 0.3459684992 0.73610536 3 61561851 61561910 60 + 0.532 0.677 0.643
ENSG00000144724 E004 11.9775255 0.002638251 0.9392622498 0.98571584 3 61561911 61562372 462 + 1.106 1.102 -0.016
ENSG00000144724 E005 7.6620584 0.010515402 0.1466332972 0.53443602 3 61748878 61748982 105 + 0.994 0.822 -0.656
ENSG00000144724 E006 0.3340335 0.027442404 0.1286441897   3 61748983 61751049 2067 + 0.000 0.243 11.653
ENSG00000144724 E007 0.1717682 0.040677133 0.3619011384   3 61769294 61771395 2102 + 0.000 0.139 10.626
ENSG00000144724 E008 7.7958497 0.003366751 0.4793366086 0.81880537 3 61989625 61989804 180 + 0.968 0.890 -0.295
ENSG00000144724 E009 9.0085900 0.003292132 0.1659344368 0.56171683 3 62003349 62003497 149 + 1.058 0.910 -0.547
ENSG00000144724 E010 9.6255625 0.011611146 0.2620091530 0.66726002 3 62078163 62078258 96 + 1.070 0.948 -0.447
ENSG00000144724 E011 10.0819228 0.002649616 0.7783873733 0.94190184 3 62132602 62132668 67 + 1.058 1.032 -0.094
ENSG00000144724 E012 12.4866387 0.002037461 0.2839039553 0.68667446 3 62157067 62157224 158 + 1.173 1.075 -0.351
ENSG00000144724 E013 13.1791040 0.003290500 0.5430931315 0.85142308 3 62167971 62168163 193 + 1.180 1.127 -0.191
ENSG00000144724 E014 13.3805999 0.002524665 0.6945726596 0.91336519 3 62191469 62191653 185 + 1.173 1.139 -0.120
ENSG00000144724 E015 11.0653767 0.002433968 0.1691884442 0.56618165 3 62195062 62195170 109 + 1.015 1.151 0.492
ENSG00000144724 E016 6.1060678 0.004122446 0.2384399616 0.64370088 3 62201505 62201554 50 + 0.784 0.930 0.566
ENSG00000144724 E017 32.3516302 0.001351382 0.0824119542 0.42271280 3 62203173 62203950 778 + 1.569 1.465 -0.355
ENSG00000144724 E018 0.0000000       3 62217583 62217877 295 +      
ENSG00000144724 E019 12.0350060 0.002810984 0.0008968778 0.05086267 3 62218851 62218983 133 + 1.225 0.890 -1.223
ENSG00000144724 E020 2.3722502 0.030278145 0.3887479671 0.76620976 3 62231225 62231311 87 + 0.457 0.603 0.692
ENSG00000144724 E021 0.1125166 0.032204076 0.6462148817   3 62243576 62243804 229 + 0.103 0.000 -10.823
ENSG00000144724 E022 0.0000000       3 62243805 62243806 2 +      
ENSG00000144724 E023 11.7493080 0.002318056 0.8349332273 0.95854679 3 62243807 62243898 92 + 1.106 1.089 -0.062
ENSG00000144724 E024 12.3157429 0.002115563 0.3139580999 0.71140396 3 62255124 62255215 92 + 1.078 1.173 0.343
ENSG00000144724 E025 12.6053652 0.025649083 0.6675029632 0.90311683 3 62262798 62262894 97 + 1.116 1.164 0.170
ENSG00000144724 E026 3.5776508 0.127899697 0.7637713767 0.93713341 3 62262895 62263465 571 + 0.613 0.677 0.276
ENSG00000144724 E027 11.2866870 0.008994011 0.7396154932 0.92900890 3 62267410 62267492 83 + 1.112 1.076 -0.130
ENSG00000144724 E028 12.9270049 0.017189897 0.7786282737 0.94196585 3 62267685 62267819 135 + 1.136 1.172 0.129
ENSG00000144724 E029 14.2028946 0.011064909 0.0885086433 0.43520011 3 62269035 62269169 135 + 1.097 1.270 0.616
ENSG00000144724 E030 17.4795753 0.001838117 0.0124178056 0.19239279 3 62271383 62271555 173 + 1.173 1.372 0.699
ENSG00000144724 E031 18.1752386 0.020382204 0.5537188227 0.85536492 3 62272946 62273081 136 + 1.253 1.311 0.205
ENSG00000144724 E032 20.5024061 0.006929117 0.3734849470 0.75554976 3 62273698 62273844 147 + 1.290 1.365 0.259
ENSG00000144724 E033 0.3535412 0.729818032 0.4788409757   3 62274712 62275872 1161 + 0.196 0.000 -10.738
ENSG00000144724 E034 16.8951678 0.001803055 0.6429629067 0.89358928 3 62275873 62275966 94 + 1.231 1.271 0.139
ENSG00000144724 E035 0.0000000       3 62275967 62276971 1005 +      
ENSG00000144724 E036 13.4930834 0.002372164 0.7521127342 0.93328528 3 62276972 62277048 77 + 1.166 1.139 -0.095
ENSG00000144724 E037 16.0661170 0.001615714 0.5595331279 0.85777566 3 62277551 62277679 129 + 1.251 1.205 -0.164
ENSG00000144724 E038 19.8225717 0.001428582 0.4825022317 0.82066534 3 62281563 62281709 147 + 1.339 1.288 -0.179
ENSG00000144724 E039 18.8935186 0.001638472 0.7070109094 0.91776037 3 62282727 62282869 143 + 1.306 1.280 -0.094
ENSG00000144724 E040 20.9666151 0.001826281 0.3925397833 0.76860729 3 62292421 62292556 136 + 1.365 1.304 -0.212
ENSG00000144724 E041 162.7568812 0.003703612 0.5929940439 0.87264624 3 62293161 62297609 4449 + 2.208 2.226 0.061