ENSG00000144161

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409573 ENSG00000144161 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZC3H8 protein_coding protein_coding 11.34275 6.855657 6.896392 2.225176 1.153603 0.008534545 1.5770371 1.4025613 0.9207079 0.3185152 0.06508463 -0.60191319 0.14241250 0.22006667 0.14313333 -0.07693333 5.755537e-01 5.163765e-05 FALSE  
ENST00000466259 ENSG00000144161 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZC3H8 protein_coding retained_intron 11.34275 6.855657 6.896392 2.225176 1.153603 0.008534545 0.3144058 0.5456947 0.0000000 0.1649649 0.00000000 -5.79622063 0.02508750 0.08686667 0.00000000 -0.08686667 5.163765e-05 5.163765e-05 FALSE  
ENST00000476902 ENSG00000144161 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZC3H8 protein_coding processed_transcript 11.34275 6.855657 6.896392 2.225176 1.153603 0.008534545 0.5525914 0.5825318 0.5457694 0.3413835 0.27500904 -0.09240625 0.05286667 0.06846667 0.08050000 0.01203333 9.971811e-01 5.163765e-05    
ENST00000495264 ENSG00000144161 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZC3H8 protein_coding retained_intron 11.34275 6.855657 6.896392 2.225176 1.153603 0.008534545 1.7156302 0.9088676 0.5217231 0.5049888 0.52172312 -0.78918177 0.12498333 0.10970000 0.05676667 -0.05293333 7.139578e-01 5.163765e-05    
MSTRG.19045.2 ENSG00000144161 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZC3H8 protein_coding   11.34275 6.855657 6.896392 2.225176 1.153603 0.008534545 2.7613371 0.9242734 1.9907960 0.6484124 0.08507012 1.09865729 0.23267500 0.10003333 0.30703333 0.20700000 3.663054e-01 5.163765e-05 TRUE  
MSTRG.19045.3 ENSG00000144161 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZC3H8 protein_coding   11.34275 6.855657 6.896392 2.225176 1.153603 0.008534545 4.3108044 2.4627081 2.9173960 0.3569482 0.76484397 0.24352598 0.41271250 0.40970000 0.41260000 0.00290000 9.910155e-01 5.163765e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000144161 E001 54.3957119 0.0382804964 0.0191129489 0.23133510 2 112211529 112212504 976 - 1.597 1.838 0.814
ENSG00000144161 E002 19.7360628 0.0166879865 0.0002347046 0.02253341 2 112212505 112212760 256 - 1.062 1.460 1.404
ENSG00000144161 E003 79.8756971 0.0083689548 0.0009610861 0.05275453 2 112212761 112215904 3144 - 1.787 1.991 0.686
ENSG00000144161 E004 63.6474042 0.0104976662 0.7990805298 0.94801568 2 112215905 112216218 314 - 1.801 1.827 0.088
ENSG00000144161 E005 102.5744101 0.0011776179 0.6779002983 0.90740686 2 112216219 112216468 250 - 1.998 2.036 0.127
ENSG00000144161 E006 1.9954698 0.3201371451 0.9185276379 0.98039508 2 112230703 112230902 200 - 0.412 0.539 0.633
ENSG00000144161 E007 34.4982272 0.0009404875 0.5887494655 0.87079344 2 112230903 112230950 48 - 1.552 1.545 -0.024
ENSG00000144161 E008 50.6544673 0.0006256574 0.1386679919 0.52330982 2 112231838 112231947 110 - 1.739 1.694 -0.153
ENSG00000144161 E009 38.4544859 0.0014709338 0.3098949791 0.70807439 2 112233260 112233325 66 - 1.622 1.590 -0.108
ENSG00000144161 E010 25.1592749 0.0011896442 0.1533694595 0.54394486 2 112233326 112233334 9 - 1.462 1.391 -0.247
ENSG00000144161 E011 27.9063972 0.0042247131 0.1539572714 0.54481614 2 112233335 112233371 37 - 1.510 1.433 -0.263
ENSG00000144161 E012 44.8939547 0.0051782330 0.0736766175 0.40349258 2 112234120 112234236 117 - 1.713 1.627 -0.291
ENSG00000144161 E013 26.3882186 0.0011976411 0.1361601372 0.51955776 2 112236562 112236585 24 - 1.481 1.407 -0.254
ENSG00000144161 E014 40.3118328 0.0008284160 0.2955259248 0.69599081 2 112236586 112236695 110 - 1.638 1.608 -0.105
ENSG00000144161 E015 54.7070336 0.0016241916 0.0112210808 0.18330383 2 112238315 112238528 214 - 1.797 1.702 -0.323
ENSG00000144161 E016 1.0116034 0.0154868295 0.0092553058   2 112238529 112238591 63 - 0.000 0.464 11.702
ENSG00000144161 E017 2.6041078 0.0077812947 0.0023327255 0.08622655 2 112240368 112240492 125 - 0.212 0.737 2.825
ENSG00000144161 E018 0.9307559 0.2204457315 0.8548286650   2 112250107 112250190 84 - 0.340 0.290 -0.323
ENSG00000144161 E019 30.4828845 0.0010454417 0.0310180983 0.28341299 2 112250191 112250272 82 - 1.552 1.444 -0.372
ENSG00000144161 E020 1.5074512 0.0115974485 0.4854208274   2 112253970 112254099 130 - 0.461 0.357 -0.567
ENSG00000144161 E021 0.7503425 0.0184613419 0.1604392726   2 112254900 112254907 8 - 0.354 0.120 -1.980
ENSG00000144161 E022 28.7469087 0.0009855167 0.0587338479 0.36841995 2 112254908 112255062 155 - 1.528 1.434 -0.324
ENSG00000144161 E023 0.1717682 0.0381349525 0.5049669897   2 112255114 112255136 23 - 0.000 0.120 9.117