ENSG00000143947

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272317 ENSG00000143947 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPS27A protein_coding protein_coding 2139.206 1309.011 1247.76 241.9918 353.9426 -0.06913563 1794.6246 1017.1655 1048.8491 200.10765 306.70106 0.04425233 0.8341250 0.7725000 0.8332667 0.06076667 0.09351774 0.02964547 FALSE  
ENST00000404735 ENSG00000143947 HEK293_DMSO_6hA HEK293_OSMI2_6hA RPS27A protein_coding protein_coding 2139.206 1309.011 1247.76 241.9918 353.9426 -0.06913563 271.0249 239.1265 166.2275 40.08391 45.64207 -0.52458885 0.1298417 0.1857667 0.1344333 -0.05133333 0.02964547 0.02964547 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000143947 E001 5.108107e+00 0.0045796969 4.085735e-01 7.794019e-01 2 55231903 55232108 206 + 0.838 0.729 -0.433
ENSG00000143947 E002 7.978911e-01 0.0166644697 2.381261e-01   2 55232306 55232330 25 + 0.129 0.335 1.749
ENSG00000143947 E003 4.673239e+00 0.0678414970 3.586711e-01 7.458258e-01 2 55232383 55232389 7 + 0.614 0.819 0.844
ENSG00000143947 E004 2.104195e+01 0.0399919463 9.522552e-02 4.486227e-01 2 55232390 55232431 42 + 1.196 1.422 0.792
ENSG00000143947 E005 3.914160e+01 0.0095683390 5.284839e-02 3.523693e-01 2 55232432 55232518 87 + 1.508 1.659 0.513
ENSG00000143947 E006 5.150126e+01 0.0041044164 1.782848e-02 2.250755e-01 2 55232519 55232632 114 + 1.627 1.772 0.493
ENSG00000143947 E007 1.259434e+02 0.0004989332 4.663583e-01 8.120334e-01 2 55232633 55232677 45 + 2.087 2.109 0.073
ENSG00000143947 E008 1.247799e+02 0.0009413584 5.802940e-01 8.670103e-01 2 55232678 55232680 3 + 2.087 2.104 0.057
ENSG00000143947 E009 1.392756e+02 0.0002533754 6.604547e-01 9.007021e-01 2 55232681 55232687 7 + 2.138 2.149 0.036
ENSG00000143947 E010 1.507608e+02 0.0002874687 8.611946e-01 9.661236e-01 2 55232688 55232688 1 + 2.177 2.179 0.008
ENSG00000143947 E011 1.809034e+02 0.0015773297 4.074336e-01 7.785450e-01 2 55232689 55232693 5 + 2.243 2.267 0.080
ENSG00000143947 E012 3.636169e+03 0.0001047197 6.306791e-12 3.732471e-08 2 55232694 55232708 15 + 3.585 3.534 -0.169
ENSG00000143947 E013 1.130556e+02 0.1102561366 3.254702e-01 7.212179e-01 2 55232709 55232712 4 + 1.843 2.161 1.069
ENSG00000143947 E014 1.310084e+03 0.0044196242 3.504484e-04 2.897827e-02 2 55232713 55232794 82 + 3.031 3.165 0.445
ENSG00000143947 E015 1.301760e+03 0.0043575966 1.387614e-04 1.640087e-02 2 55232795 55232807 13 + 3.024 3.165 0.471
ENSG00000143947 E016 5.114887e+03 0.0009962640 1.032924e-01 4.631446e-01 2 55232808 55232813 6 + 3.716 3.696 -0.066
ENSG00000143947 E017 9.168800e+03 0.0003722860 3.951986e-01 7.700988e-01 2 55232814 55232872 59 + 3.959 3.958 -0.003
ENSG00000143947 E018 1.160276e+02 0.0205147791 6.615644e-02 3.870239e-01 2 55232873 55233356 484 + 1.965 2.123 0.529
ENSG00000143947 E019 3.184610e+01 0.0154242033 1.381821e-01 5.225828e-01 2 55233357 55233362 6 + 1.421 1.566 0.496
ENSG00000143947 E020 1.099169e+04 0.0001776381 4.252915e-01 7.894460e-01 2 55233363 55233417 55 + 4.036 4.037 0.004
ENSG00000143947 E021 5.236054e+01 0.0833780411 4.406501e-01 7.980822e-01 2 55233418 55233833 416 + 1.642 1.773 0.444
ENSG00000143947 E022 1.179330e+04 0.0003347991 1.656190e-01 5.613188e-01 2 55234119 55234204 86 + 4.068 4.066 -0.007
ENSG00000143947 E023 4.213069e+01 0.0607053243 4.451996e-01 8.007900e-01 2 55234205 55234561 357 + 1.553 1.680 0.434
ENSG00000143947 E024 4.726107e+01 0.0786241570 4.366350e-01 7.955980e-01 2 55234562 55234830 269 + 1.600 1.731 0.444
ENSG00000143947 E025 1.282136e+04 0.0007815880 6.350665e-01 8.902242e-01 2 55234831 55234962 132 + 4.094 4.110 0.054
ENSG00000143947 E026 7.149536e+01 0.0588307431 1.747480e-01 5.725278e-01 2 55234963 55235184 222 + 1.733 1.930 0.664
ENSG00000143947 E027 3.806320e+01 0.0014069814 1.449509e-01 5.321552e-01 2 55235413 55235427 15 + 1.534 1.620 0.291
ENSG00000143947 E028 9.082608e+03 0.0003664094 3.385075e-01 7.309179e-01 2 55235428 55235853 426 + 3.944 3.961 0.058